Mechanism of dTTP Inhibition of the Bifunctional dCTP Deaminase:dUTPase Encoded by Mycobacterium tuberculosis

Journal of Molecular Biology

Volumn 376, Issue 2, 2008, Pages 554-569

  Helt, Signe Smedegaard ^a   Thymark, Majbritt ^b   Harris, Pernille ^a   Aagaard, Claus ^c   Dietrich, Jes ^c   Larsen, Sine ^b,d   Willemoes, Martin ^b  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

catalytic mechnism; deamination; deoxy ribonucleotide metabolism; dUTP; enzyme regulation

Indexed keywords

DEOXYCYTIDINE TRIPHOSPHATE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; THYMIDINE TRIPHOSPHATE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SYNTHESIS; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ESCHERICHIA COLI; METHANOCALDOCOCCUS JANNASCHII; MYCOBACTERIUM TUBERCULOSIS;

EID: 38349191358     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.11.099     Document Type: Article

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