Lox-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model

Infection and Immunity

Volumn 79, Issue 7, 2011, Pages 2865-2870

  Wu, Zhuang ^a   Sawamura, Tatsuya ^b   Kurdowska, Anna K ^a   Ji, Hong Long ^a   Idell, Steven ^a   Fu, Jian ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE DELETION; IMMUNE RESPONSE; KNOCKOUT MOUSE; LIGATION; LUNG EDEMA; LUNG INJURY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PUNCTURE; SEPSIS; SURVIVAL RATE; WILD TYPE;

ANIMALS; CECUM; CYTOKINES; ENDOTHELIAL CELLS; INFLAMMATION; INFLAMMATION MEDIATORS; LUNG INJURY; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PNEUMONIA; RECEPTORS, INTERLEUKIN-8B; SCAVENGER RECEPTORS, CLASS E; SEPSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 79959469314     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01317-10     Document Type: Article

References (45)

1. Alves-Filho, J. C., A. de Freitas, M. Russo, and F. Q. Cunha. 2006. Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit. Care Med. 34:461-470.
2. Alves-Filho, J. C., A. de Freitas, F. Spiller, F. O. Souto, and F. Q. Cunha. 2008. The role of neutrophils in severe sepsis. Shock 30(Suppl. 1):3-9.
3. Alves-Filho, J. C., et al. 2009. Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc. Natl. Acad. Sci. U. S. A. 106:4018-4023.
4. Aomatsu, K., et al. 2008. Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. Immunology 123:171-180.
5. Apte, R. N., et al. 2006. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis nd tumor-host interactions. Cancer Metastasis Rev. 25:387-408.
6. Boxio, R., C. Bossenmeyer-Pourie, N. Steinckwich, C. Dournon, and O. Nusse. 2004. Mouse bone marrow contains large numbers of functionally competent neutrophils. J. Leukoc. Biol. 75:604-611.
7. Buras, J. A., B. Holzmann, and M. Sitkovsky. 2005. Animal models of sepsis: setting the stage. Nat. Rev. Drug Discov. 4:854-865.
8. Craig, A., J. Mai, S. Cai, and S. Jeyaseelan. 2009. Neutrophil recruitment to the lungs during bacterial pneumonia. Infect. Immun. 77:568-575.
9. Decker, T. 2004. Sepsis: avoiding its deadly toll. J. Clin. Invest. 113:1387- 1389.
10. de Jong, H. K., T. van der Poll, and W. J. Wiersinga. 2010. The systemic pro-inflammatory response in sepsis. J. Innate Immun. 2:422-430.
11. Deng, J. C., et al. 2006. Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J. Clin. Invest. 116:2532-2542.
12. Dunn, S., et al. 2008. The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. Biochem. J. 409:349-355.
13. Everhart, M. B., et al. 2006. Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. J. Immunol. 176:4995-5005.
14. Fu, J., A. P. Naren, X. Gao, G. U. Ahmmed, and A. B. Malik. 2005. Proteaseactivated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J. Biol. Chem. 280:3178-3184.
15. Gao, H., S. K. Leaver, A. Burke-Gaffney, and S. J. Finney. 2008. Severe sepsis and Toll-like receptors. Semin. Immunopathol. 30:29-40.
16. Gao, X. P., et al. 2007. Blockade of class IA phosphoinositide 3-kinase in neutrophils prevents NADPH oxidase activation- and adhesion-dependent inflammation. J. Biol. Chem. 282:6116-6125.
17. Goodman, R. B., J. Pugin, J. S. Lee, and M. A. Matthay. 2003. Cytokinemediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 14:523-535.
18. Hu, C., et al. 2007. LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion. Cardiovasc. Res. 76:292-302.
19. Juffermans, N. P., et al. 2000. Expression of the chemokine receptors CXCR1 and CXCR2 on granulocytes in human endotoxemia and tuberculosis: involvement of the p38 mitogen-activated protein kinase pathway. J. Infect. Dis. 182:888-894.
20. Kamochi, M., et al. 1999. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am. J. Physiol. 277:L310-L319.
21. Kang, J. L., et al. 2001. Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am. J. Respir. Crit. Care Med. 164:2206-2212.
22. Khandaker, M. H., et al. 1998. CXCR1 and CXCR2 are rapidly downmodulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism. J. Immunol. 161:1930-1938.
23. Koh, A. Y., G. P. Priebe, C. Ray, N. Van Rooijen, and G. B. Pier. 2009. Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect. Immun. 77:5300-5310.
24. Li, D., et al. 2002. Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1. J. Pharmacol. Exp. Ther. 302:601-605.
25. Lyn-Kew, K., and T. J. Standiford. 2008. Immunosuppression in sepsis. Curr. Pharm. Des. 14:1870-1881.
26. Matsunaga, T., S. Hokari, I. Koyama, T. Harada, and T. Komoda. 2003. NF-kappa B activation in endothelial cells treated with oxidized high-density lipoprotein. Biochem. Biophys. Res. Commun. 303:313-319.
27. McGovern, N. N., et al. 2011. Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils. J. Immunol. 186:453-463.
28. Mehta, J. L., J. Chen, P. L. Hermonat, F. Romeo, and G. Novelli. 2006. Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc. Res. 69:36-45.
29. Mehta, J. L., et al. 2007. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ. Res. 100:1634-1642.
30. Moreno, S. E., et al. 2006. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J. Immunol. 177:3218-3224.
31. Muller Kobold, A. C., et al. 2000. Leukocyte activation in sepsis; correlations with disease state and mortality. Intensive Care Med. 26:883-892.
32. Oka, K., et al. 1998. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 95:9535-9540.
33. Reddy, R. C., G. H. Chen, P. K. Tekchandani, and T. J. Standiford. 2001. Sepsis-induced immunosuppression: from bad to worse. Immunol. Res. 24: 273-287.
34. Reddy, R. C., and T. J. Standiford. 2010. Effects of sepsis on neutrophil chemotaxis. Curr. Opin. Hematol. 17:18-24.
35. Renckens, R., et al. 2006. Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsis. J. Immunol. 176:3735-3741.
36. Shih, H. H., et al. 2009. CRP is a novel ligand for the oxidized LDL receptor LOX-1. Am. J. Physiol. Heart Circ. Physiol. 296:H1643-H1650.
37. Shimaoka, T., et al. 2001. Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin. FEBS Lett. 504:65-68.
38. Shimaoka, T., et al. 2001. LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J. Immunol. 166:5108-5114.
39. Shin, H. K., Y. K. Kim, K. Y. Kim, J. H. Lee, and K. W. Hong. 2004. Remnant lipoprotein particles induce apoptosis in endothelial cells by NAD(P)H oxidase-mediated production of superoxide and cytokines via lectin-like oxidized low-density lipoprotein receptor-1 activation: prevention by cilostazol. Circulation 109:1022-1028.
40. Tavares-Murta, B. M., et al. 2002. Failure of neutrophil chemotactic function in septic patients. Crit. Care Med. 30:1056-1061.
41. Tsai, W. C., et al. 2000. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect. Immun. 68:4289-4296.
42. van den Blink, B., et al. 2004. P38 mitogen activated protein kinase is involved in the downregulation of granulocyte CXC chemokine receptors 1 and 2 during human endotoxemia. J. Clin. Immunol. 24:37-41.
43. van der Poll, T., and J. C. Meijers. 2010. Systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome in sepsis. J. Innate Immun. 2:379-380.
44. Van Ziffle, J. A., and C. A. Lowell. 2009. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114:4871- 4882.
45. Xu, X., X. Gao, B. J. Potter, J. M. Cao, and C. Zhang. 2007. Anti-LOX-1 rescues endothelial function in coronary arterioles in atherosclerotic ApoE knockout mice. Arterioscler. Thromb. Vasc. Biol. 27:871-877.