-
1
-
-
67651241759
-
ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy
-
Aceves-Luquero, C. I., et al. 2009. ERK2, but not ERK1, mediates acquired and "de novo" resistance to imatinib mesylate: implication for CML therapy. PLoS One 4:e6124.
-
(2009)
PLoS One
, vol.4
-
-
Aceves-Luquero, C.I.1
-
2
-
-
66249148694
-
Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia
-
Agirre, X., et al. 2009. Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia. Cancer Res. 69:4443-4453.
-
(2009)
Cancer Res
, vol.69
, pp. 4443-4453
-
-
Agirre, X.1
-
3
-
-
44049091757
-
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
-
Amin, R. H., and M. S. Schlissel. 2008. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat. Immunol. 9:613-622.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 613-622
-
-
Amin, R.H.1
Schlissel, M.S.2
-
4
-
-
0344553913
-
An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement
-
Chen, Y. Y., L. C. Wang, M. S. Huang, and N. Rosenberg. 1994. An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 8:688-697.
-
(1994)
Genes Dev
, vol.8
, pp. 688-697
-
-
Chen, Y.Y.1
Wang, L.C.2
Huang, M.S.3
Rosenberg, N.4
-
5
-
-
77449092637
-
PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells
-
Choe, K. S., O. Ujhelly, S. N. Wontakal, and A. I. Skoultchi. 2010. PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells. J. Biol. Chem. 285:3044-3052.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 3044-3052
-
-
Choe, K.S.1
Ujhelly, O.2
Wontakal, S.N.3
Skoultchi, A.I.4
-
6
-
-
0030712867
-
Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation
-
Deed, R. W., E. Hara, G. T. Atherton, G. Peters, and J. D. Norton. 1997. Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation. Mol. Cell. Biol. 17:6815-6821.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 6815-6821
-
-
Deed, R.W.1
Hara, E.2
Atherton, G.T.3
Peters, G.4
Norton, J.D.5
-
7
-
-
0038503565
-
Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes
-
Ericson, K. K., D. Krull, P. Slomiany, and M. J. Grossel. 2003. Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytes. Mol. Cancer Res. 1:654-664.
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 654-664
-
-
Ericson, K.K.1
Krull, D.2
Slomiany, P.3
Grossel, M.J.4
-
8
-
-
34249015960
-
Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells
-
Feldhahn, N., et al. 2007. Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells. J. Exp. Med. 204:1157-1166.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1157-1166
-
-
Feldhahn, N.1
-
9
-
-
9444228344
-
Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts
-
Fry, D. W., et al. 2004. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol. Cancer Ther. 3:1427-1438.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1427-1438
-
-
Fry, D.W.1
-
10
-
-
0037069382
-
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system
-
Greenbaum, S., and Y. Zhuang. 2002. Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system. Proc. Natl. Acad. Sci. U. S. A. 99:15030-15035.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 15030-15035
-
-
Greenbaum, S.1
Zhuang, Y.2
-
11
-
-
0033569748
-
cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain
-
Grossel, M. J., G. L. Baker, and P. W. Hinds. 1999. cdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domain. J. Biol. Chem. 274:29960-29967.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 29960-29967
-
-
Grossel, M.J.1
Baker, G.L.2
Hinds, P.W.3
-
12
-
-
33144460031
-
Beyond the cell cycle: a new role for Cdk6 in differentiation
-
Grossel, M. J., and P. W. Hinds. 2006. Beyond the cell cycle: a new role for Cdk6 in differentiation. J. Cell Biochem. 97:485-493.
-
(2006)
J. Cell Biochem.
, vol.97
, pp. 485-493
-
-
Grossel, M.J.1
Hinds, P.W.2
-
13
-
-
67651174451
-
Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors
-
Grosso, S., et al. 2009. Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors. Mol. Cancer Ther. 8:1924-1933.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 1924-1933
-
-
Grosso, S.1
-
14
-
-
0031024647
-
Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors
-
Hara, E., M. Hall, and G. Peters. 1997. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J. 16: 332-342.
-
(1997)
EMBO J
, vol.16
, pp. 332-342
-
-
Hara, E.1
Hall, M.2
Peters, G.3
-
15
-
-
61349152914
-
E and ID proteins branch out
-
Kee, B. L. 2009. E and ID proteins branch out. Nat. Rev. Immunol. 9:175-184.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 175-184
-
-
Kee, B.L.1
-
16
-
-
16844366670
-
ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors
-
Kharas, M. G., and D. A. Fruman. 2005. ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors. Cancer Res. 65:2047-2053.
-
(2005)
Cancer Res
, vol.65
, pp. 2047-2053
-
-
Kharas, M.G.1
Fruman, D.A.2
-
17
-
-
0028299725
-
The v-abl tyrosine kinase negatively regulates NFkappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes
-
Klug, C. A., et al. 1994. The v-abl tyrosine kinase negatively regulates NFkappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes. Genes Dev. 8:678-687.
-
(1994)
Genes Dev
, vol.8
, pp. 678-687
-
-
Klug, C.A.1
-
18
-
-
0032439213
-
Essential roles for the Abl and Arg tyrosine kinases in neurulation
-
Koleske, A. J., et al. 1998. Essential roles for the Abl and Arg tyrosine kinases in neurulation. Neuron 21:1259-1272.
-
(1998)
Neuron
, vol.21
, pp. 1259-1272
-
-
Koleske, A.J.1
-
19
-
-
0037374815
-
The role of PI3K in immune cells
-
Koyasu, S. 2003. The role of PI3K in immune cells. Nat. Immunol. 4:313-319.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 313-319
-
-
Koyasu, S.1
-
20
-
-
31344465701
-
E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells
-
Lazorchak, A. S., M. S. Schlissel, and Y. Zhuang. 2006. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. Mol. Cell. Biol. 26:810-821.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 810-821
-
-
Lazorchak, A.S.1
Schlissel, M.S.2
Zhuang, Y.3
-
21
-
-
33845925394
-
Chromatin immunoprecipitation and microarray-based analysis of protein location
-
Lee, T. I., S. E. Johnstone, and R. A. Young. 2006. Chromatin immunoprecipitation and microarray-based analysis of protein location. Nat. Protoc. 1:729-748.
-
(2006)
Nat. Protoc.
, vol.1
, pp. 729-748
-
-
Lee, T.I.1
Johnstone, S.E.2
Young, R.A.3
-
22
-
-
0023280348
-
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility
-
Lenardo, M., J. W. Pierce, and D. Baltimore. 1987. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 236:1573-1577.
-
(1987)
Science
, vol.236
, pp. 1573-1577
-
-
Lenardo, M.1
Pierce, J.W.2
Baltimore, D.3
-
23
-
-
0032485070
-
Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells
-
Mahony, D., D. A. Parry, and E. Lees. 1998. Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells. Oncogene 16:603-611.
-
(1998)
Oncogene
, vol.16
, pp. 603-611
-
-
Mahony, D.1
Parry, D.A.2
Lees, E.3
-
24
-
-
60749109846
-
Cell cycle. CDKs and cancer: a changing paradigm
-
Malumbres, M., and M. Barbacid. 2009. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 9:153-166.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 153-166
-
-
Malumbres, M.1
Barbacid, M.2
-
25
-
-
70349445270
-
Ras orchestrates exit from the cell cycle and lightchain recombination during early B cell development
-
Mandal, M., et al. 2009. Ras orchestrates exit from the cell cycle and lightchain recombination during early B cell development. Nat. Immunol. 10: 1110-1117.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1110-1117
-
-
Mandal, M.1
-
26
-
-
0038375546
-
CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells
-
Matushansky, I., F. Radparvar, and A. I. Skoultchi. 2003. CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 22:4143-4149.
-
(2003)
Oncogene
, vol.22
, pp. 4143-4149
-
-
Matushansky, I.1
Radparvar, F.2
Skoultchi, A.I.3
-
27
-
-
0034687713
-
Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G1
-
Matushansky, I., F. Radparvar, and A. I. Skoultchi. 2000. Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G1. Proc. Natl. Acad. Sci. U. S. A. 97:14317-14322.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 14317-14322
-
-
Matushansky, I.1
Radparvar, F.2
Skoultchi, A.I.3
-
28
-
-
33947386190
-
Resistance to imatinib mesylate in chronic myeloid leukaemia
-
Melo, J. V., and C. Chuah. 2007. Resistance to imatinib mesylate in chronic myeloid leukaemia. Cancer Lett. 249:121-132.
-
(2007)
Cancer Lett
, vol.249
, pp. 121-132
-
-
Melo, J.V.1
Chuah, C.2
-
29
-
-
0037232230
-
A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines
-
Muljo, S. A., and M. S. Schlissel. 2003. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. Nat. Immunol. 4:31-37.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 31-37
-
-
Muljo, S.A.1
Schlissel, M.S.2
-
30
-
-
23044456914
-
p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells
-
Munoz-Alonso, M. J., et al. 2005. p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells. J. Biol. Chem. 280:18120-18129.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18120-18129
-
-
Munoz-Alonso, M.J.1
-
31
-
-
27544442994
-
Helix-loop-helix proteins and lymphocyte development
-
Murre, C. 2005. Helix-loop-helix proteins and lymphocyte development. Nat. Immunol. 6:1079-1086.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1079-1086
-
-
Murre, C.1
-
32
-
-
0032573088
-
p19Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation
-
Radfar, A., I. Unnikrishnan, H. W. Lee, R. A. DePinho, and N. Rosenberg. 1998. p19Arf induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation. Proc. Natl. Acad. Sci. U. S. A. 95:13194-13199.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 13194-13199
-
-
Radfar, A.1
Unnikrishnan, I.2
Lee, H.W.3
DePinho, R.A.4
Rosenberg, N.5
-
33
-
-
0028411110
-
Abl-mediated transformation, immunoglobulin gene rearrangements and arrest of B lymphocyte differentiation
-
Rosenberg, N. 1994. Abl-mediated transformation, immunoglobulin gene rearrangements and arrest of B lymphocyte differentiation. Semin. Cancer Biol. 5:95-102.
-
(1994)
Semin. Cancer Biol.
, vol.5
, pp. 95-102
-
-
Rosenberg, N.1
-
34
-
-
0024202338
-
The viral and cellular forms of the Abelson (abl) oncogene
-
Rosenberg, N., and O. N. Witte. 1988. The viral and cellular forms of the Abelson (abl) oncogene. Adv. Virus Res. 35:39-81.
-
(1988)
Adv. Virus Res.
, vol.35
, pp. 39-81
-
-
Rosenberg, N.1
Witte, O.N.2
-
35
-
-
1842614414
-
p16Ink4a interferes with Abelson virus transformation by enhancing apoptosis
-
Sachs, Z., N. E. Sharpless, R. A. DePinho, and N. Rosenberg. 2004. p16Ink4a interferes with Abelson virus transformation by enhancing apoptosis. J. Virol. 78:3304-3311.
-
(2004)
J. Virol.
, vol.78
, pp. 3304-3311
-
-
Sachs, Z.1
Sharpless, N.E.2
DePinho, R.A.3
Rosenberg, N.4
-
36
-
-
33745591644
-
Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development
-
Schwartz, R., I. Engel, M. Fallahi-Sichani, H. T. Petrie, and C. Murre. 2006. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc. Natl. Acad. Sci. U. S. A. 103:9976-9981.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 9976-9981
-
-
Schwartz, R.1
Engel, I.2
Fallahi-Sichani, M.3
Petrie, H.T.4
Murre, C.5
-
37
-
-
0025923088
-
Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations
-
Schwartzberg, P. L., et al. 1991. Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65:1165-1175.
-
(1991)
Cell
, vol.65
, pp. 1165-1175
-
-
Schwartzberg, P.L.1
-
38
-
-
0022481133
-
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
-
Sen, R., and D. Baltimore. 1986. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:705-716.
-
(1986)
Cell
, vol.46
, pp. 705-716
-
-
Sen, R.1
Baltimore, D.2
-
39
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah, N. P., et al. 2002. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2:117-125.
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
-
40
-
-
0029850508
-
Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase
-
Skorski, T., et al. 1996. Blastic transformation of p53-deficient bone marrow cells by p210bcr/abl tyrosine kinase. Proc. Natl. Acad. Sci. U. S. A. 93:13137-13142.
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, pp. 13137-13142
-
-
Skorski, T.1
-
41
-
-
0030849536
-
Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells
-
Thome, K. C., A. Radfar, and N. Rosenberg. 1997. Mutation of Tp53 contributes to the malignant phenotype of Abelson virus-transformed lymphoid cells. J. Virol. 71:8149-8156.
-
(1997)
J. Virol.
, vol.71
, pp. 8149-8156
-
-
Thome, K.C.1
Radfar, A.2
Rosenberg, N.3
-
42
-
-
0025780879
-
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
-
Tybulewicz, V. L., C. E. Crawford, P. K. Jackson, R. T. Bronson, and R. C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65:1153-1163.
-
(1991)
Cell
, vol.65
, pp. 1153-1163
-
-
Tybulewicz, V.L.1
Crawford, C.E.2
Jackson, P.K.3
Bronson, R.T.4
Mulligan, R.C.5
-
43
-
-
0022536364
-
Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer
-
Weinberger, J., D. Baltimore, and P. A. Sharp. 1986. Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer. Nature 322:846-848.
-
(1986)
Nature
, vol.322
, pp. 846-848
-
-
Weinberger, J.1
Baltimore, D.2
Sharp, P.A.3
-
44
-
-
2542441665
-
The BCR-ABL story: bench to bedside and back
-
Wong, S., and O. N. Witte. 2004. The BCR-ABL story: bench to bedside and back. Annu. Rev. Immunol. 22:247-306.
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 247-306
-
-
Wong, S.1
Witte, O.N.2
-
45
-
-
0035725846
-
Promotion of cell cycle progression by basic helix-loop-helix E2A
-
Zhao, F., A. Vilardi, R. J. Neely, and J. K. Choi. 2001. Promotion of cell cycle progression by basic helix-loop-helix E2A. Mol. Cell. Biol. 21:6346-6357.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 6346-6357
-
-
Zhao, F.1
Vilardi, A.2
Neely, R.J.3
Choi, J.K.4
-
46
-
-
0030999886
-
Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclindependent kinases
-
Zou, X., S. Rudchenko, K. Wong, and K. Calame. 1997. Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclindependent kinases. Genes Dev. 11:654-662.
-
(1997)
Genes Dev
, vol.11
, pp. 654-662
-
-
Zou, X.1
Rudchenko, S.2
Wong, K.3
Calame, K.4
|