Loss of allostery and coenzyme B12 delivery by a pathogenic mutation in adenosyltransferase

Biochemistry

Volumn 50, Issue 25, 2011, Pages 5790-5798

  Lofgren, Michael ^a   Banerjee, Ruma ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ADENOSYLCOBALAMIN; ADJACENT SITES; ALLOSTERY; BIFUNCTIONAL PROTEINS; C-TERMINAL TRUNCATION; COFACTORS; COOPERATIVITY; DIRECT TRANSFER; HOMOTRIMERS; METHYLMALONIC ACIDURIA; METHYLMALONYL-COA MUTASE; METHYLOBACTERIUM; PATHOGENIC MUTATION; TRUNCATION MUTANTS; WILD TYPES;

ADENOSINE TRIPHOSPHATE; ADENOSYLTRANSFERASE; COBAMAMIDE; METHYLMALONYL COENZYME A MUTASE; TRANSFERASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; METHYLMALONIC ACIDURIA; METHYLOBACTERIUM EXTORQUENS; MUTATIONAL ANALYSIS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS; THERMAL ANALYSIS; THERMODYNAMICS;

ALLOSTERIC REGULATION; AMINO ACID METABOLISM, INBORN ERRORS; AMINO ACID SEQUENCE; COBAMIDES; GENE DELETION; HUMANS; METHIONINE ADENOSYLTRANSFERASE; METHYLOBACTERIUM EXTORQUENS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN TRANSPORT;

METHYLOBACTERIUM EXTORQUENS;

EID: 79959437104     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2006306     Document Type: Article

References (33)

1. 12: catalysis by cobalamin-dependent enzymes Annu. Rev. Biochem. 72, 209-247 (Pubitemid 36930446)
2. 12 (Banerjee, R., Ed.) Wiley, New York.
3. Banerjee, R. a. C. S. (1999) Methylmalonly-CoA mutase in Chemistry and Biochemistry of B12 (Banerjee, R., Ed.), Wiley, New York.
4. 12 Appl. Microbiol. Biotechnol. 88, 41-48
5. Tsang, A. W. and Escalante-Semerena, J. C. (1996) cobB function is required for catabolism of propionate in Salmonella typhimurium LT2: evidence for existence of a substitute function for CobB within the 1,2-propanediol utilization (pdu) operon J. Bacteriol. 178, 7016-7019 (Pubitemid 26404985)
6. Suh, S. and Escalante-Semerena, J. C. (1995) Purification and initial characterization of the ATP:corrinoid adenosyltransferase encoded by the cobA gene of Salmonella typhimurium J. Bacteriol. 177, 921-925
7. 12-dependent methylmalonic aciduria Hum. Mol. Genet. 11, 3361-3369 (Pubitemid 36054664)
8. Leal, N. A., Park, S. D., Kima, P. E., and Bobik, T. A. (2003) Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant J. Biol. Chem. 278, 9227-9234 (Pubitemid 36800405)
9. 12 trafficking in mammals: A for coenzyme escort service ACS Chem. Biol. 1, 149-159
10. Banerjee, R., Gherasim, C., and Padovani, D. (2009) The Tinker, Tailor, Soldier in intracellular B12 Trafficking Curr. Opin. Chem. Biol. 13, 477-484
11. 12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins J. Biol. Chem. 284, 33418-33424
12. Kim, J., Gherasim, C., and Banerjee, R. (2008) Decyanation of vitamin B12 by a trafficking chaperone Proc. Natl. Acad. Sci. U.S.A. 105, 14551-14554
13. 12 Nat. Chem. Biol. 4, 194-196 (Pubitemid 351264128)
14. Jorge-Finnigan, A., Aguado, C., Sanchez-Alcudia, R., Abia, D., Richard, E., Merinero, B., Gamez, A., Banerjee, R., Desviat, L. R., Ugarte, M., and Perez, B. (2010) Functional and structural analysis of five mutations identified in methylmalonic aciduria cbl B type Hum. Mutat. 31, 1033-1042
15. 12-dependent methylmalonic aciduria Mol. Genet. Metab. 87, 219-225 (Pubitemid 43325036)
16. Mera, P. E., St, Maurice, M., Rayment, I., and Escalante-Semerena, J. C. (2007) Structural and functional analyses of the human-type corrinoid adenosyltransferase (PduO) from Lactobacillus reuteri Biochemistry 46, 13829-13836 (Pubitemid 350223910)
17. Mera, P., St, Maurice, M., Rayment, I., and Escalante-Semerena, J. (2009) Residue Phe112 of the Human-type Corrinoid Adenosyltransferase (PduO) Enzyme of Lactobacillus reuteri is Critical to the Formation of the Four-coordinate Co(II) Corrinoid Substrate and to the Activity of the Enzyme Biochemistry 48, 3138-3145
18. 12 is synthesized through a four-coordinate intermediate Biochemistry 47, 5755-5766 (Pubitemid 351747054)
19. St Maurice, M., Mera, P. E., Taranto, M. P., Sesma, F., Escalante-Semerena, J. C., and Rayment, I. (2007) Structural characterization of the active site of the PduO-type ATP:Co(I)rrinoid adenosyltransferase from Lactobacillus reuteri J. Biol. Chem. 282, 2596-2605 (Pubitemid 47076765)
20. 12 Synthesis by Adenosyltransferase Biochemistry 48, 5350-5357
21. 12 loading and is corrupted in methylmalonic aciduria Proc. Natl. Acad. Sci. U.S.A. 106, 21567-21572
22. Stich, T. A., Buan, N. R., Escalante-Semerena, J. C., and Brunold, T. C. (2005) Spectroscopic and computational studies of the ATP:corrinoid adenosyltransferase (CobA) from Salmonella enterica: insights into the mechanism of adenosylcobalamin biosynthesis J. Am. Chem. Soc. 127, 8710-8719 (Pubitemid 40868254)
23. 2+ cobalamin species upon binding to the human ATP:cobalamin adenosyltransferase J. Am. Chem. Soc. 127, 7660-7661 (Pubitemid 40745938)
24. Mera, P. E. and Escalante-Semerena, J. C. (2010) Dihydroflavin-driven adenosylation of 4-coordinate Co(II) corrinoids: are cobalamin reductases enzymes or electron transfer proteins? J. Biol. Chem. 285, 2911-2917
25. Park, K., Mera, P. E., Escalante-Semerena, J. C., and Brunold, T. C. (2008) Kinetic and spectroscopic studies of the ATP:corrinoid adenosyltransferase PduO from Lactobacillus reuteri: substrate specificity and insights into the mechanism of Co(II)corrinoid reduction Biochemistry 47, 9007-9015
26. 12 in human adenosyltransferase and its downstream target, methylmalonyl-CoA mutase J. Am. Chem. Soc. 127, 526-527 (Pubitemid 40174370)
27. Padovani, D. and Banerjee, R. (2009) A rotary mechanism for coenzyme B(12) synthesis by adenosyltransferase Biochemistry 48, 5350-5357
28. Schubert, H. L. and Hill, C. P. (2006) Structure of ATP-bound human ATP:cobalamin adenosyltransferase Biochemistry 45, 15188-15196 (Pubitemid 46032445)
29. Zoldak, G., Zubrik, A., Musatov, A., Stupak, M., and Sedlak, E. (2004) Irreversible thermal denaturation of glucose oxidase from Aspergillus niger is the transition to the denatured state with residual structure J. Biol. Chem. 279, 47601-47609 (Pubitemid 39540905)
30. 12-dependent methylmalonyl-CoA mutase J. Biol. Chem. 281, 17838-17844 (Pubitemid 44035582)
31. Leal, N. A., Olteanu, H., Banerjee, R., and Bobik, T. A. (2004) Human ATP: Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase J. Biol. Chem. 279, 47536-47542 (Pubitemid 39540898)
32. Saridakis, V., Yakunin, A., Xu, X., Anandakumar, P., Pennycooke, M., Gu, J., Cheung, F., Lew, J. M., Sanishvili, R., Joachimiak, A., Arrowsmith, C. H., Christendat, D., and Edwards, A. M. (2004) The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase J. Biol. Chem. 279, 23646-23653 (Pubitemid 38685680)
33. Johnson, C. L., Buszko, M. L., and Bobik, T. A. (2004) Purification and initial characterization of the Salmonella enterica PduO ATP:Cob(I)alamin adenosyltransferase J. Bacteriol. 186, 7881-7887 (Pubitemid 39552498)