Iron deposition and inflammation in multiple sclerosis. Which one comes first?

BMC Neuroscience

Volumn 12, Issue , 2011, Pages

  Zivadinov, Robert ^a,b   Weinstock Guttman, Bianca ^b   Pirko, Istvan ^c  

^a UNIVERSITY AT BUFFALO   (United States)

^b JACOBS NEUROLOGICAL INSTITUTE   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Animal model; CCSVI; Cerebral EAE; Inflammation; Iron deposition; Multiple sclerosis

Indexed keywords

IRON;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; CELL ACTIVATION; CELL INFILTRATION; CHRONIC CEREBROSPINAL VENOUS INSUFFICIENCY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; IMMUNOPATHOGENESIS; INFLAMMATION; IRON STORAGE; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NEURODEGENERATION WITH BRAIN IRON ACCUMULATION; NONHUMAN; NOTE; ONSET AGE; ANIMAL; ASTROCYTE; BRAIN CIRCULATION; BRAIN CORTEX; EDITORIAL; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ASTROCYTES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INFLAMMATION; IRON; MICE; MULTIPLE SCLEROSIS; NEURONS;

EID: 79959406713     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-12-60     Document Type: Note

References (25)

1. Stankiewicz J, Panter SS, Neema M, Arora A, Batt CE, Bakshi R. Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics 2007, 4(3):371-386. 10.1016/j.nurt.2007.05.006, 1963417, 17599703.
2. Williams R, Rohr AM, Wang W, Choi I, Lee P, Berman N, Lynch S, LeVine SM. Iron deposition is independent of cellular inflammation and vascular changes in a cerebral model of multiple sclerosis. BMC Neuroscience 2011, 12:59.
3. LeVine SM. Iron deposits in multiple sclerosis and Alzheimer's disease brains. Brain Res 1997, 760:(1-2):298-303. 10.1016/S0006-8993(97)00269-2, 9237511.
4. Craelius W, Migdal MW, Luessenhop CP, Sugar A, Mihalakis I. Iron deposits surrounding multiple sclerosis plaques. Archives of pathology & laboratory medicine 1982, 106(8):397.
5. Adams CW. Perivascular iron deposition and other vascular damage in multiple sclerosis. British Medical Journal 1988, 51(2):260.
6. Zivadinov R, Schirda C, Dwyer MG, Haacke ME, Weinstock-Guttman B, Menegatti E, Heininen-Brown M, Magnano C, Malagoni AM, Wack DS. Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility weighted imaging in patients with multiple sclerosis: a pilot case-control study. Int Angiol 2010, 29:158-175.
7. Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, Hu J, Selvan M, Wu Z, Latif Z, Xuan Y, et al. Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. Journal of Magnetic Resonance Imaging 2009, 29(3):537-544. 10.1002/jmri.21676, 2650739, 19243035.
8. Barnham KJ, Masters CL, Bush AI. Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov 2004, 3(3):205-214. 10.1038/nrd1330, 15031734.
9. Aquino D, Bizzi A, Grisoli M, Garavaglia B, Bruzzone MG, Nardocci N, Savoiardo M, Chiapparini L. Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects. Radiology 2009, 252(1):165-172. 10.1148/radiol.2522081399, 19561255.
10. Hallgren B, Sourander P. The effect of age on the non-haemin iron in the human brain. J Neurochem 1958, 3(1):41-51. 10.1111/j.1471-4159.1958.tb12607.x, 13611557.
11. Kalman B, Laitinen K, Komoly S. The involvement of mitochondria in the pathogenesis of multiple sclerosis. J Neuroimmunol 2008, 188(1-2):1-12.
12. Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'ara S, Bartolomei I, Salvi F. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2009, 80(4):392-399. 2647682, 19060024.
13. Singh AV, Zamboni P. Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab 2009, 29(12):1867-1878. 10.1038/jcbfm.2009.180, 19724286.
14. Zamboni P. The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med 2006, 99(11):589-593. 10.1258/jrsm.99.11.589, 1633548, 17082306.
15. Haacke EM, Garbern J, Miao Y, Habib C, Liu M. Iron stores and cerebral veins in MS studied by susceptibility weighted imaging. Int Angiol 2010, 29(2):149-157.
16. Tallantyre EC, Brookes MJ, Dixon JE, Morgan PS, Evangelou N, Morris PG. Demonstrating the perivascular distribution of MS lesions in vivo with 7-Tesla MRI. Neurology 2008, 70(22):2076-2078. 10.1212/01.wnl.0000313377.49555.2e, 18505982.
17. Tallantyre EC, Morgan PS, Dixon JE, Al-Radaideh A, Brookes MJ, Evangelou N, Morris PG. A comparison of 3T and 7T in the detection of small parenchymal veins within MS lesions. Invest Radiol 2009, 44(9):491-494. 10.1097/RLI.0b013e3181b4c144, 19652606.
18. LeVine SM, Chakrabarty A. The Role of Iron in the Pathogenesis of Experimental Allergic Encephalomyelitis and Multiple Sclerosis. Annals of the New York Academy of Sciences 2004, 1012(1):252-266. 10.1196/annals.1306.021, 15105271.
19. Young NP, Weinshenker BG, Parisi JE, Scheithauer B, Giannini C, Roemer SF, Thomsen KM, Mandrekar JN, Erickson BJ, Lucchinetti CF. Perivenous demyelination: association with clinically defined acute disseminated encephalomyelitis and comparison with pathologically confirmed multiple sclerosis. Brain 2010, 133(Pt 2):333-348. 2822631, 20129932.
20. Porto G, De Sousa M. Iron overload and immunity. World J Gastroenterol 2007, 13(35):4707-4715.
21. Wakefield AJ, More LJ, Difford J, McLaughlin JE. Immunohistochemical study of vascular injury in acute multiple sclerosis. J Clin Pathol 1994, 47(2):129-133. 10.1136/jcp.47.2.129, 501826, 8132826.
22. Zivadinov R, Marr K, Cutter G, Ramanathan M, Benedict RH, Kennedy C, Elfadil M, Yeh AE, Reuther J, Brooks C, et al. Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS. Neurology 2011,
23. Baracchini C, Perini P, Calabrese M, Causin F, Rinaldi F, Gallo P. No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. Ann Neurol 2011, 69(1):90-99. 10.1002/ana.22228, 21280079.
24. Yamout B, Herlopian A, Issa Z, Habib RH, Fawaz A, Salame J, Wadih A, Awdeh H, Muallem N, Raad R, et al. Extracranial venous stenosis is an unlikely cause of multiple sclerosis. Mult Scler 2010, 16(11):1341-1348. 10.1177/1352458510385268, 21041329.
25. Forge JK, Pedchenko TV, LeVine SM. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Life Sci 1998, 63(25):2271-2284. 10.1016/S0024-3205(98)00512-8, 9870713.