Iron stores and cerebral veins in MS studied by susceptibility weighted imaging

International Angiology

Volumn 29, Issue 2, 2010, Pages 149-157

  Haacke, E M ^a   Garbern, J ^a   Miao, Y ^b   Habib, C ^a   Liu, M ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral veins; Iron; Multiple sclerosis

Indexed keywords

BIOLOGICAL MARKER; IRON;

ADULT; AGED; ARTICLE; BASAL GANGLION; BLOOD VESSEL INJURY; BRAIN VEIN; CAUDATE NUCLEUS; CHRONIC CEREBROSPINAL VENOUS INSUFFICIENCY; CHRONIC VEIN INSUFFICIENCY; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC IMAGING; GLOBUS PALLIDUS; HUMAN; HYPERTENSION; HYPOTHESIS; INFORMATION; IRON BLOOD LEVEL; IRON STORAGE; MULTIPLE SCLEROSIS; PULVINAR; PUTAMEN; RED NUCLEUS; SUBSTANTIA NIGRA; SUSCEPTIBILITY WEIGHTED IMAGING; THALAMUS; VELOCITY; VENOUS PRESSURE;

ADULT; AGED; BASAL GANGLIA; BIOLOGICAL MARKERS; CEREBRAL VEINS; HUMANS; IRON; MAGNETIC RESONANCE ANGIOGRAPHY; MIDDLE AGED; MULTIPLE SCLEROSIS; THALAMUS; UP-REGULATION; VENOUS INSUFFICIENCY; VENOUS PRESSURE; YOUNG ADULT;

EID: 77952843658     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Zamboni P, Galeotti R, Menegatti E, Malagoni AM, Tacconi G, Dall'Ara S et al. Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2009;80:392-399
2. Adams CW. Perivascular iron deposition and other vascular damage in multiple sclerosis. J Neurol Neurosurg Psychiatry 1988;51:260-265
3. Fog T. On the Vessel-plaque relationships in the brain in multiple sclerosis. Acta Neurol Scand Suppl 1964;40:Suppl 10:15-19
4. Schelling F. Damaging venous reflux into the skull or spine: relevance to multiple sclerosis. Med Hypotheses 1986;21:141-148 (Pubitemid 17201924)
5. Zamboni P. The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med 2006;99:589-593 (Pubitemid 44876813)
6. Singh AV, Zamboni P. Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab 2009;29:1867-1878
7. Bergan JJ, Pascarella L, Schmid-Schonbein GW. Pathogenesis of primary chronic venous disease: Insights from animal models of venous hypertension. J Vasc Surg 2008;47:183-192
8. Bergan JJ, Schmid-Schonbein GW, Smith PD, Nicolaides AN, Boisseau MR, Eklof B. Chronic venous disease. N Engl J Med 2006;355:488-498
9. Zamboni P, Menegatti E, Bartolomei I, Galeotti R, Malagoni AM, Tacconi G et al. Intracranial venous haemodynamics in multiple sclerosis. Curr Neurovasc Res 2007;4:252-258
10. Trojano M, Manzari C, Livrea P. Blood-brain barrier changes in multiple sclerosis. Ital J Neurol Sci 1992;13:55-64-
11. Ge Y, Zohrabian VM, Osa EO, Xu J, Jaggi H, Herbert J et al. Diminished visibility of cerebral venous vasculature in multiple sclerosis by susceptibility-weighted imaging at 3.0 Tesla. J Magn Reson Imaging 2009;29:1190-1194
12. Law M, Saindane AM, Ge Y, Babb JS, Johnson G, Mannon LJ et al. Microvascular abnormality in relapsing-remitting multiple sclerosis: perfusion MR imaging findings in normal-appearing white matter. Radiology 2004;231:645-652
13. Wuerfel J, Bellmann-Strobl J, Brunecker P, Aktas O, McFarland H, Villringer A et al. Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study. Brain 2004;127:111-119 (Pubitemid 38055350)
14. Neema M, Arora A, Healy BC, Guss ZD, Brass SD, Duan Y et al. Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging 2009;19:3-8.
15. Haacke EM, Mittal S, Wu Z, Neelavalli J, Cheng YC. Susceptibility- weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol 2009;30:19-30.
16. Reichenbach JR, Venkatesan R, Schillinger DJ, Kido DK, Haacke EM. Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 1997;204:272-277 (Pubitemid 27281745)
17. Haacke EM, Xu Y, Cheng YC, Reichenbach JR. Susceptibility weighted imaging (SWI). Magn Reson Med 2004;52:612-618
18. Ogawa S, Lee TM, Kay AR, Tank DW. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 1990;87:9868-9872 (Pubitemid 120016545)
19. Haacke EM, Ayaz M, Khan A, Manova ES, Krishnamurthy B, Gollapalli L et al. Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 2007;26:256-264 (Pubitemid 47257722)
20. Haacke EM, Miao YW, Liu M, Habib CA, Liu T, Yang Z et al. Correlation of change in R2* and phase with putative iron content in deep gray matter of healthy adults. J Magn Reson Imaging 2010 In Press.
21. Haacke EM, Cheng NY, House MJ, Liu Q, Neelavalli J, Ogg RJ et al. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 2005;23:1-25. (Pubitemid 40269946)
22. Putnam TJ, Adler A. MS plaques spread along the periventricular veins. Arch of Neurology and Psychiatry 1937;38:1-15.
23. Bakshi R, Benedict RH, Bermel RA, Caruthers SD, Puli SR, Tjoa CW et al. T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study. Arch Neurol 2002;59:62-68 (Pubitemid 34052557)
24. Drayer B, Burger P, Hurwitz B, Dawson D, Cain J. Reduced signal intensity on MR images of thalamus and putamen in multiple sclerosis: increased iron content? AJR Am J Roentgenol 1987;149:357-363
25. Drayer BP, Burger P, Hurwitz B, Dawson D, Cain J, Leong J et al. Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen. Ann Neurol 1987;22:546-550
26. Khalil M, Enzinger C, Langkammer C, Tscherner M, Wallner-Blazek M, Jehna M et al. Quantitative assessment of brain iron by R(2)* relaxometry in patients with clinically isolated syndrome and relapsing-remitting multiple sclerosis. Mult Scler 2009;15:1048-1054
27. Walter U, Wagner S, Horowski S, Benecke R, Zettl UK. Transcranial brain sonography findings predict disease progression in multiple sclerosis. Neurology 2009;73:1010-1017
28. Craelius W, Migdal MW, Luessenhop CP, Sugar A, Mihalakis I. Iron deposits surrounding multiple sclerosis plaques. Arch Pathol Lab Med 1982;106:397-399
29. Levine SM, Chakrabarty A. The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann N Y Acad Sci 2004;1012:252-266
30. Forge JK, Pedchenko TV, LeVine SM. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Life Sci 1998;63:2271-2284
31. Pedchenko TV, LeVine SM. Desferrioxamine suppresses experimental allergic encephalomyelitis induced by MBP in SJL mice. J Neuroimmunol 1998;84:188-197 (Pubitemid 28248405)
32. Hammond KE, Metcalf M, Carvajal L, Okuda DT, Srinivasan R, Vigneron D et al. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol 2008;64:707-713
33. Schenck JF, Zimmerman EA. High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed 2004;17:433-445
34. Walton JC, Kaufmann JC. Iron deposits and multiple sclerosis. Arch Pathol Lab Med 1984;108:755-756
35. Nandigam RN, Viswanathan A, Delgado P, Skehan ME, Smith EE, Rosand J et al. MR imaging detection of cerebral microbleeds: effect of susceptibility- weighted imaging, section thickness, and field strength. AJNR Am J Neuroradiol 2009;30:338-343
36. Ayaz M, Boikov AS, Haacke EM, Kido DK, Kirsch WM. Imaging cerebral microbleeds using susceptibility weighted imaging: one step toward detecting vascular dementia. J Magn Reson Imaging 2010;31:142-148
37. Ogg RJ, Langston JW, Haacke EM, Steen RG, Taylor JS. The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 1999;17:1141-1148
38. Wismer GL, Buxton RB, Rosen BR, Fisel CR, Oot RF, Brady TJ et al. Susceptibility induced MR line broadening: applications to brain iron mapping. J Comput Assist Tomogr 1988;12:259-265
39. Xu X, Wang Q, Zhang M. Age, gender, and hemispheric differences in iron deposition in the human brain: an in vivo MRI study. Neuroimage 2008;40:35-42.
40. Mittal S, Wu Z, Neelavalli J, Haacke EM. Susceptibility-weighted imaging: technical aspects and clinical applications, part 2. AJNR Am J Neuroradiol 2009;30:232-252
41. Roccatagliata L, Vuolo L, Bonzano L, Pichiecchio A, Mancardi GL. Multiple sclerosis: hyperintense dentate nucleus on unenhanced T1-weighted MR images is associated with the secondary progressive subtype. Radiology 2009;251:503-510
42. Tjoa CW, Benedict RH, Weinstock-Guttman B, Fabiano AJ, Bakshi R. MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis. J Neurol Sci 2005;234:17-24. (Pubitemid 40910338)
43. KeU DB. Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics 2009;2:2.
44. Thomas M, Jankovic J. Neurodegenerative disease and iron storage in the brain. Curr Opin Neurol 2004;17:437-442 (Pubitemid 39071420)
45. Sullivan JL. Is stored iron safe? J Lab Clin Med 2004;144:280-284
46. Patt A, Horesh IR, Berger EM, Harken AH, Repine JE. Iron depletion or chelation reduces ischemia/reperfusion-induced edema in gerbil brains. J Pediatr Surg 1990;25:224-227; discussion 227-228. (Pubitemid 20046193)
47. Grant SM, Wiesinger JA, Beard JL, Cantorna MT. Iron-deficient mice fail to develop autoimmune encephalomyelitis. J Nutr 2003;133:2635-2638
48. Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M et al. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals. PNAS 2009;106:8302-8307.
49. Rudick RA, Trapp BD. Gray-matter injury in multiple sclerosis. N Engl J Med 2009;361:1505-1506