Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to α2β1 integrin and collagen

Toxicon

Volumn 55, Issue 6, 2010, Pages 1093-1099

  Tanjoni, Isabelle ^a   Evangelista, Karla ^b   Della Casa, Maisa S ^a   Butera, Diego ^a   Magalhães, Geraldo S ^a   Baldo, Cristiani ^a   Clissa, Patrícia B ^a   Fernandes, Irene ^a   Eble, Johannes ^b   Moura da Silva, Ana M ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Antibodies; Collagen; Integrin; Jararhagin; Metalloproteinase; Snake venoms

Indexed keywords

COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; EPITOPE; JARARHAGIN; METALLOPROTEINASE; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ADULT; ARTICLE; BASEMENT MEMBRANE; BLEEDING; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; COLLAGEN; CROTALID VENOMS; HUMANS; INTEGRIN ALPHA2BETA1; K562 CELLS; METALLOENDOPEPTIDASES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 77649335773     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.12.010     Document Type: Article

References (31)

1. Andrews R.K., Kamiguti A.S., Berlanga O., Leduc M., Theakston R.D.G., and Watson S.P. The use of snake venom toxins as tools to study platelet receptors for collagen and von Willebrand factor. Haemostasis 31 (2001) 155-172
2. Andrews R.K., and Berndt M.C. Platelet physiology and thrombosis. Thromb. Res. 114 (2004) 447-453
3. De Luca M., Ward C.M., Ohmori K., Andrews R.K., and Berndt M.C. Jararhagin and jaracetin: novel snake venom inhibitors of the integrin collagen receptor, α2β1. Biochem. Biophys. Res. Commun. 206 (1995) 570-576
4. Eble J.A., Wucherpfennig K.W., Gauthier L., Dersch P., Krukonis E., Isberg R.R., and Hemler M.E. Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner. Biochemistry 37 (1998) 10945-10955
5. Fox J.W., and Serrano S.M.T. Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity. FEBS J. 275 (2008) 3016-3030
6. Hsu C.C., Wu W.B., and Huang T.F. A snake venom metalloproteinase, kistomin, cleaves platelet glycoprotein VI and impairs platelet functions. J. Thromb. Haemost. 6 (2008) 1578-1585
7. Igarashi T., Araki S., Mori H., and Takeda S. Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins. FEBS Lett. 581 (2007) 2416-2422
8. Ivaska J., Kapyla J., Pentikainen O., Hoffren A.M., Hermonen J., Huttunen P., Johnson M.S., and Heino J. A peptide inhibiting the collagen binding function of integrin alpha2I domain. J. Biol. Chem. 274 (1999) 3513-3521
9. Jia L.G., Wang X.M., Shannon J.D., Bjarnason J.B., and Fox J.W. Function of disintegrin-like/cysteine-rich domains of atrolysin-A. Inhibition of platelet aggregation by recombinant protein and peptide antagonists. J. Biol. Chem. 272 (1997) 13094-13102
10. Kamiguti A.S., Hay C.R., and Zuzel M. Inhibition of collagen-induced platelet aggregation as the result of cleavage of alpha 2 beta 1-integrin by the snake venom metalloproteinase jararhagin. Biochem. J. 320 (1996) 635-641
11. Kamiguti A.S., Moura-da-Silva A.M., Laing G.D., Knapp T., Zuzel M., Crampton J.M., and Theakston R.D.G. Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin. Biochem. Biophys. Acta 1335 (1997) 209-217
12. Kamiguti A.S., Theakston R.D.G., Watson S.P., Bon C., Laing G.D., and Zuzel M. Distinct contributions of glycoprotein VI and alpha(2)beta(1) integrin to the induction of platelet protein tyrosine phosphorylation and aggregation. Arch. Biochem. Biophys. 374 (2000) 356-364
13. Kamiguti A.S., Gallager P., Marcinkiewicz C., Theakston R.D.G., Zuzel M., and Fox J.W. Identification of sites in the cysteine-rich domain of the class P-III snake venom metalloproteinase responsible for the inhibition of platelet function. FEBS Lett. 549 (2003) 129-134
14. Liu C.Z., and Huang T.F. Crovidisin, a collagen-binding protein isolated from snake venom of Crotalus viridis, prevents platelet-collagen interaction. Arch. Biochem. Biophys. 337 (1997) 291-299
15. Menezes M.C., Paes-Leme A.F., Melo R.L., Silva C.A., Della-Casa M., Bruni F.M., Lima C., Lopes-Ferreira M., Camargo A.C., Fox J.W., and Serrano S.M. Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3, a snake venom hemorrhagic metalloproteinase. FEBS Lett. 582 (2008) 3915-3921
16. Moura-da-Silva A.M., Línica A., Della-Casa M.S., Kamiguti A.S., Ho P.L., Crampton J.M., and Theakston R.D.G. Jararhagin ECD-disintegrin-like domain: expression in Escherichia coli and inhibition of the platelet-collagen interaction. Arch. Biochem. Biophys. 369 (1999) 295-301
17. Moura-da-Silva A.M., Marcinkiewicz C., Marcinkiewicz M., and Niewiarowski S. Selective recognition of alpha2beta1 integrin by jararhagin, a Metalloproteinase/disintegrin from Bothrops jararaca venom. Thromb. Res. 102 (2001) 153-159
18. Moura-da-Silva A.M., Della-Casa M.S., David A.S., Assakura M.T., Butera D., Lebrun I., Shannon J.D., Serrano S.M.T., and Fox J.W. Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability. Arch. Biochem. Biophys. 409 (2003) 395-401
19. Moura-da-Silva A.M., Butera D., and Tanjoni I. Importance of snake venom metalloproteinases in cell biology: effects on platelets, inflammatory and endothelial cells. Curr. Pharm. Des. 13 (2007) 2893-2905
20. Moura-da-Silva A.M., Ramos O.H.P., Baldo C., Niland S., Hansen U., Ventura J.S., Furlan S., Butera D., Della-Casa M.S., Tanjoni I., Clissa P.B., Fernandes I., Chudzinski-Tavassi A.M., and Eble J.A. Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases. Biochimie 90 (2008) 484-492
21. Paine M.J.I., Desmond H.P., Theakston R.D.G., and Cramton J.M. Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. J. Biol. Chem. 267 (1992) 22869-22876
22. Raynal N., Hamaia S.W., Siljander P.R.M., Maddox B., Peachey A.R., Fernandez R., Foley L.J., Slatter D.A., Jarvis G.E., and Farndale R.W. Use of synthetic peptides to locate novel integrin α2β1-binding motifs in human collagen III. J. Biol. Chem. 281 (2006) 3821-3831
23. Serrano S.M.T., Kim J., Wang D., Dragulev B., Shannon J.D., Mann H.H., Veit G., Wagener R., Koch M., and Fox J.W. The cysteine-rich domain of snake venom metalloproteinases is a ligand for von Willebrand factor A domains: role in substrate targeting. J. Biol. Chem. 281 (2006) 39746-39756
24. Serrano S.M.T., Wang D., Shannon J.D., Pinto A.F., Polanowska-Grabowska R.K., and Fox J.W. Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation. FEBS J. 274 (2007) 3611-3621
25. Takeda S., Igarashi T., Mori H., and Araki S. Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold. EMBO J. 25 (2006) 2388-2396
26. Tanjoni I., Butera D., Bento L., Della-Casa M.S., Marques-Porto R., Takehara H.A., Gutiérrez J.M., Fernandes I., and Moura-da-Silva A.M. Snake venom metalloproteinases: structure/function relationships using monoclonal antibodies. Toxicon 42 (2003) 801-808
27. Tanjoni I., Weinlich R., Della Casa M.S., Clissa P.B., Saldanha-Gama R.F., Freitas M.S., Barja-Fidalgo C., Amarante-Mendes G.P., and Moura-da-Silva A.M. Jararhagin, a snake venom toxin, induces a specialized form of apoptosis (anoikis) selective to endothelial cells. Apoptosis 10 (2005) 851-861
28. Usami Y., Fujimura Y., Miura S., Shima H., Yoshida E., Yoshioka A., Hirano K., Suzuki M., and Titani K. A 28-kDa protein with disintegrin-like-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen and ADP-induced platelet aggregation. Biochem. Biophys. Res. Commun. 201 (1994) 331-339
29. Zigrino P., Kamiguti A.S., Eble J.A., Drescher C., Nischt R., Fox J.W., and Mauch C. The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling. J. Biol. Chem. 277 (2002) 40528-40533
30. Zhou Q., Smith J.B., and Grossman M.H. Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (western diamondback rattlesnake) which inhibits platelet adhesion to collagen. Biochem. J. 307 (1995) 411-417
31. Zhou Q., Dangelmaier C., and Smith J.B. The hemorrhagin catrocollastatin inhibits collagen-induced platelet aggregation by binding to collagen via its disintegrin-like domain. Biochem. Biophys. Res. Commun. 219 (1996) 720-726