Mitsunobu inversion of a secondary alcohol with diphenylphosphoryl azide. application to the enantioselective multikilogram synthesis of a HCV polymerase inhibitor

Organic Process Research and Development

Volumn 15, Issue 5, 2011, Pages 1116-1123

  Scott, Jeremy P ^a   Alam, Mahbub ^a   Bremeyer, Nadine ^a   Goodyear, Adrian ^a   Lam, Thientu ^b   Wilson, Robert D ^a   Zhou, George ^b  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL STUDY; DRUG CANDIDATES; EFFICIENT CONSTRUCTION; ENANTIOSELECTIVE; ENANTIOSELECTIVE SYNTHESIS; HAZARD EVALUATION; HEPATITIS C VIRUS; MITSUNOBU INVERSION; PROCESS DEVELOPMENT; SECONDARY ALCOHOLS; SECONDARY AMINES; STEREOCENTERS;

ENANTIOSELECTIVITY; VIRUSES;

SYNTHESIS (CHEMICAL);

EID: 79959376296     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op200002u     Document Type: Article

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