Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 384, Issue 1, 2011, Pages 59-70

  Chang, Yi ^a,b   Lin, Yu Wan ^c   Wang, Su Jane ^b  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Ca v2.2 (N type) and Ca v2.1 (P Q type) channels; Cerebral cortex; Glutamate release; Idebenone; Protein kinase A; Synaptosomes

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 AMINOPYRIDINE; 7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; BAFILOMYCIN A1; CYCLIC AMP DEPENDENT PROTEIN KINASE; DANTROLENE; GLUTAMIC ACID; IDEBENONE; KT 5720; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OMEGA CONOTOXIN MVIIC;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN SYNAPTOSOME; CALCIUM BLOOD LEVEL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CHELATION; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG MECHANISM; EVOKED CORTICAL RESPONSE; EXTRACELLULAR CALCIUM; INHIBITION KINETICS; MALE; NEUROPROTECTION; NONHUMAN; RAT; SODIUM CALCIUM EXCHANGE;

4-AMINOPYRIDINE; ANIMALS; ASPARTIC ACID; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM SIGNALING; CARBAZOLES; CEREBRAL CORTEX; CLONAZEPAM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DANTROLENE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMIC ACID; INDOLES; ISOQUINOLINES; MACROLIDES; MALE; MALEIMIDES; MEMBRANE POTENTIALS; NERVE ENDINGS; OMEGA-CONOTOXINS; POTASSIUM; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-CALCIUM EXCHANGER; SULFONAMIDES; SYNAPTOSOMES; THIAZEPINES; UBIQUINONE;

EID: 79959372971     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-011-0630-1     Document Type: Article

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