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UNAIDS Report on the Global AIDS Epidemic, 2010; Joint United Nations Programme on HIV/AIDS 2010. This paper gives an excellent global view of HIV.
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The most recent paper with incidence estimates in a resource-rich country
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Le Vu S, Le Strat Y, Barin F, et al. Population-based HIV-1 incidence in France, 2003-08: a modelling analysis. Lancet Infect Dis 2010; 10:682-687. The most recent paper with incidence estimates in a resource-rich country.
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A long-term cohort study with detailed analysis of HIV transmission among MSM
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Jansen IA, Geskus RB, Davidovich U, et al. Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study. AIDS 2011; 25:493-501. A long-term cohort study with detailed analysis of HIV transmission among MSM.
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77956057163
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Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco
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The paper by Das et al. demonstrated an ecological association of a reduction in total population level viral load with declining numbers of new HIV diagnoses. These data were from San Francisco where the vast majority of HIV cases followed was MSM. These provocative data suggest that expanding HIV treatment will reduce HIV incidence. However, these studies do not count people not in care and the relationship could be confounded by other factors
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Das M, Chu PL, Santos GM, et al. Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PLoS One 2010; 5:e11068. The paper by Das et al. demonstrated an ecological association of a reduction in total population level viral load with declining numbers of new HIV diagnoses. These data were from San Francisco where the vast majority of HIV cases followed was MSM. These provocative data suggest that expanding HIV treatment will reduce HIV incidence. However, these studies do not count people not in care and the relationship could be confounded by other factors.
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PLoS One
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Das, M.1
Chu, P.L.2
Santos, G.M.3
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18
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Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: A population-based study
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Motaner et al. also show an ecological association of population level viral load with declining numbers of new HIV diagnoses. The effect observed was driven primarily by the reduction in HIV incident cases in intravenous drug users
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Montaner JS, Lima VD, Barrios R, et al. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet 2010; 376:532-539. Motaner et al. also show an ecological association of population level viral load with declining numbers of new HIV diagnoses. The effect observed was driven primarily by the reduction in HIV incident cases in intravenous drug users.
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Lancet
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Montaner, J.S.1
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Granich RM, Gilks CF, Dye C, et al. Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009; 373:48-57.
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Granich, R.M.1
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20
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A cluster of Kaposi's sarcoma and Pneumocystis carinii pneumonia among homosexual male residents of Los Angeles and Orange Counties, California
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MMWR Morb Mortal Wkly Rep
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Rethinking the heterosexual infectivity of HIV-1: A systematic review and meta-analysis
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Cohen, M.S.4
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24
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77953942340
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HIV transmission risk through anal intercourse: Systematic review, meta-analysis and implications for HIV prevention
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This paper is the most complete review of the risk of HIV transmission from anal sex
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Baggaley RF, White RG, Boily MC. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol 2010; 39:1048-1063. This paper is the most complete review of the risk of HIV transmission from anal sex.
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Int J Epidemiol
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Baggaley, R.F.1
White, R.G.2
Boily, M.C.3
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25
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The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men
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Jameson DR, Celum CL, Manhart L, et al. The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men. Sex Transm Dis 2010; 37:147-152.
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Jameson, D.R.1
Celum, C.L.2
Manhart, L.3
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26
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77958033400
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Circumcision among men who have sex with men in Scotland: Limited potential for HIV prevention
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McDaid LM, Weiss HA, Hart GJ. Circumcision among men who have sex with men in Scotland: limited potential for HIV prevention. Sex Transm Infect 2010; 86:404-406.
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McDaid, L.M.1
Weiss, H.A.2
Hart, G.J.3
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27
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Male circumcision and risk of HIV acquisition among MSM
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Sanchez J, Sal YRVG, Hughes JP, et al. Male circumcision and risk of HIV acquisition among MSM. AIDS 2010; 25:519-523.
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Sanchez, J.1
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Male circumcision to reduce the risk of HIV and sexually transmitted infections among men who have sex with men
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Templeton DJ, Millett GA, Grulich AE. Male circumcision to reduce the risk of HIV and sexually transmitted infections among men who have sex with men. Curr Opin Infect Dis 2010; 23:45-52.
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Millett, G.A.2
Grulich, A.E.3
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29
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77951816810
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Circumcision status and HIV infection among MSM: Reanalysis of a phase III HIV vaccine clinical trial
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Gust DA, Wiegand RE, Kretsinger K, et al. Circumcision status and HIV infection among MSM: reanalysis of a phase III HIV vaccine clinical trial. AIDS 2010; 24:1135-1143.
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Gust, D.A.1
Wiegand, R.E.2
Kretsinger, K.3
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Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 trial
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Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomised controlled trial
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Bailey RC, Moses S, Parker CB, et al. Male circumcision for HIV prevention in young men in Kisumu, Kenya: a randomised controlled trial. Lancet 2007; 369:643-656.
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Bailey, R.C.1
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Parker, C.B.3
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Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial
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Gray RH, Kigozi G, Serwadda D, et al. Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial. Lancet 2007; 369:657-666.
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Gray, R.H.1
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Serwadda, D.3
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33
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77951850863
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Male circumcision in the United States for the prevention of HIV infection and other adverse health outcomes: Report from a CDC consultation
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A report on the status of circumcision for MSM on HIV transmission
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Smith DK, Taylor A, Kilmarx PH, et al. Male circumcision in the United States for the prevention of HIV infection and other adverse health outcomes: report from a CDC consultation. Public Health Rep 2010; 125 (Suppl 1):72-82. A report on the status of circumcision for MSM on HIV transmission.
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Smith, D.K.1
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Kilmarx, P.H.3
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34
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Preexposure chemoprophylaxis for HIV prevention in men who have sex with men
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The paper by Grant et al. demonstrates that ART is effective in prevention of HIV acquisition but does not begin to answer how this could be implemented or how real world effectiveness will be
-
Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N Engl J Med 2010; 363:2587-2599. The paper by Grant et al. demonstrates that ART is effective in prevention of HIV acquisition but does not begin to answer how this could be implemented or how real world effectiveness will be.
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N Engl J Med
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Grant, R.M.1
Lama, J.R.2
Anderson, P.L.3
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Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: A prospective cohort analysis
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Donnell D, Baeten JM, Kiarie J, et al. Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 2010; 375:2092-2098.
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Donnell, D.1
Baeten, J.M.2
Kiarie, J.3
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Christopoulos KA, Das M, Colfax GN. Linkage and retention in HIV care among men who have sex with men in the United States. Clin Infect Dis 2011; 52 (Suppl 2):S214-S222.
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Awareness of postexposure HIV prophylaxis in high-risk men who have sex with men in New York City
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Mehta SA, Silvera R, Bernstein K, et al. Awareness of postexposure HIV prophylaxis in high-risk men who have sex with men in New York City. Sex Transm Infect 2011. [Epub ahead of print]
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Mehta, S.A.1
Silvera, R.2
Bernstein, K.3
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38
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77953040583
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Longitudinal analysis of patterns and predictors of changes in self-reported adherence to antiretroviral therapy: Swiss HIV Cohort Study
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The paper by Glass et al. is important in that it shows the long-term ART adherence reported by a large cohort of HIV-infected individuals and that 100% adherence was not the norm. However, the number of missed doses is not well quantified and, therefore, is uncertain whether there was significant viral breakthrough
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Glass TR, Battegay M, Cavassini M, et al. Longitudinal analysis of patterns and predictors of changes in self-reported adherence to antiretroviral therapy: Swiss HIV Cohort Study. J Acquir Immune Defic Syndr 2010; 54:197-203. The paper by Glass et al. is important in that it shows the long-term ART adherence reported by a large cohort of HIV-infected individuals and that 100% adherence was not the norm. However, the number of missed doses is not well quantified and, therefore, is uncertain whether there was significant viral breakthrough.
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J Acquir Immune Defic Syndr
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Glass, T.R.1
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Cavassini, M.3
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39
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77951879238
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HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men
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The paper by Rieder et al. shows that transmission of HIV could be traced to individuals who had discontinued ART in the Swiss Cohort after early treatment for primary infection. This suggests that continued use of ART could have prevented these transmissions
-
Rieder P, Joos B, von Wyl V, et al. HIV-1 transmission after cessation of early antiretroviral therapy among men having sex with men. AIDS 2010; 24:1177-1183. The paper by Rieder et al. shows that transmission of HIV could be traced to individuals who had discontinued ART in the Swiss Cohort after early treatment for primary infection. This suggests that continued use of ART could have prevented these transmissions.
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AIDS
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Rieder, P.1
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Von Wyl, V.3
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A longitudinal analysis of sociodemographic and health correlates of sexual health among HIV-infected men in the USA
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Jeffries WL, Zsembik BA, Peek CW, Uphold CR. A longitudinal analysis of sociodemographic and health correlates of sexual health among HIV-infected men in the USA. Sex Health 2009; 6:285-292.
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Determinants of recent HIV infection among Seattle-area men who have sex with men
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Thiede H, Jenkins RA, Carey JW, et al. Determinants of recent HIV infection among Seattle-area men who have sex with men. Am J Public Health 2009; 99 (Suppl 1):S157-S164.
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78649879210
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Frequency and determinants of unprotected sex among HIV-infected persons: The Swiss HIV cohort study
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The paper by Hasse et al. reported reasons for condom use among a large cohort of HIV-infected men. In particular, MSM were less likely to use a condom with a seroconcordant partner and if they were on ART. This suggests MSM make decisions on condom use based on a perception of lower transmission risk
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Hasse B, Ledergerber B, Hirschel B, et al. Frequency and determinants of unprotected sex among HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis 2010; 51:1314-1322. The paper by Hasse et al. reported reasons for condom use among a large cohort of HIV-infected men. In particular, MSM were less likely to use a condom with a seroconcordant partner and if they were on ART. This suggests MSM make decisions on condom use based on a perception of lower transmission risk.
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