Serpins and the complement system

Methods in Enzymology

Volumn 499, Issue , 2011, Pages 55-75

  Beinrohr, László ^a   Murray Rust, Thomas A ^b   Dyksterhuis, Leanne ^b   Závodszky, Péter ^a   Gál, Péter ^a   Pike, Robert N ^b   Wijeyewickrema, Lakshmi C ^b  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b MONASH UNIVERSITY   (Australia)

Author keywords

C1 inhibitor; Complement proteases; Fermentation; Human plasma; Jacalin agarose chromatography; Pichia pastoris; Recombinant protein expression; Serpin G1

Indexed keywords

COMPLEMENT; COMPLEMENT COMPONENT C1; COMPLEMENT COMPONENT C1S; COMPLEMENT INHIBITOR; COMPLEMENTARY DNA; MACROGOL; METHIONINE; PROTEINASE; RECOMBINANT COMPLEMENT C1 INHIBITOR; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VALINE;

AFFINITY CHROMATOGRAPHY; ARTICLE; BATCH FERMENTATION; BIOREACTOR; BLOOD SAMPLING; DRUG PURIFICATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GENE CONSTRUCT; GENE EXPRESSION; GLYCOSYLATION; HUMAN; IMMUNOPRECIPITATION; ION EXCHANGE CHROMATOGRAPHY; MOLECULAR CLONING; NONHUMAN; PICHIA PASTORIS; PLASMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; STOICHIOMETRY; SUPERNATANT; WESTERN BLOTTING;

PICHIA PASTORIS;

EID: 79959330463     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386471-0.00004-3     Document Type: Chapter

References (28)

1. G. Ambrus, P. Gál, M. Kojima, K. Szilágyi, J. Balczer, J. Antal, L. Gráf, A. Laich, B.E. Moffatt, W. Schwaeble, R.B. Sim, and P. Závodszky Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: A study on recombinant catalytic fragments J. Immunol. 170 2003 1374 1382 (Pubitemid 36139504)
2. L. Beinrohr, V. Harmat, J. Dobó, Z. Lrincz, P. Gál, and P. Závodszky C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease J. Biol. Chem. 282 2007 21100 21109 (Pubitemid 47099924)
3. L. Beinrohr, J. Dobó, P. Závodszky, and P. Gál C1, MBL-MASPs and C1-inhibitor: Novel approaches for targeting complement-mediated inflammation Trends Mol. Med. 14 2008 511 521
4. L. Beinrohr Doctoral thesis Structural basis of C1-inhibitor specificity and deficiency 2009 Etvs Loránd University http://www.doktori.hu/index. php?menuid=193&vid=4196&lang=EN
5. S.C. Bock, K. Skriver, E. Nielsen, H.C. Thogersen, B. Wiman, V.H. Donaldson, R.L. Eddy, J. Marrinan, E. Radziejewska, R. Huber, R. Huber, T.B. Shows, and S. Magnusson Human C1 inhibitor: Primary structure, cDNA cloning, and chromosomal localization Biochemistry 25 1986 4292 4301 (Pubitemid 16054244)
6. I.G. Bos, E.C. de Bruin, Y.A. Karuntu, P.W. Modderman, E. Eldering, and C.E. Hack Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor Biochim. Biophys. Acta 1648 2003 75 83 (Pubitemid 38234608)
7. J.L. Cereghino, and J.M. Cregg Heterologous protein expression in the methylotrophic yeast Pichia pastoris FEMS Microbiol. Rev. 24 2000 45 66 (Pubitemid 30047114)
8. M. Cugno, A. Zanichelli, F. Foieni, S. Caccia, and M. Cicardi C1-inhibitor deficiency and angioedema: Molecular mechanisms and clinical progress Trends Mol. Med. 15 2009 69 78
9. S.A. Cumming, D.J. Halsall, P.W. Ewan, and D.A. Lomas The effect of sequence variations within the coding region of the C1 inhibitor gene on disease expression and protein function in families with hereditary angio-oedema J. Med. Genet. 40 2003 e114
10. J. Dóbo, V. Harmat, L. Beinrohr, E. Sebestyén, P. Závodszky, and P. Gál MASP-1, a promiscuous complement protease: Structure of its catalytic region reveals the basis of its broad specificity J. Immunol. 183 2009 1207 1214
11. P.S. Hiemstra, A. Gorter, M.E. Stuurman, L.A. Van Es, and M.R. Daha The IgA-binding lectin jacalin induces complement activation by inhibition of C-1-inactivator function Scand. J. Immunol. 26 1987 111 117
12. F.K. Kerr, A.R. Thomas, L.C. Wijeyewickrema, J.C. Whisstock, S.E. Boyd, D. Kaiserman, A.Y. Matthews, P.I. Bird, N.M. Thielens, V. Rossi, and R.N. Pike Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor Mol. Immunol. 45 2007 670 677 (Pubitemid 47498592)
13. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
14. T. Lamark, M. Ingebrigtsen, C. Bjornstad, T. Melkko, T.E. Mollnes, and E.W. Nielsen Expression of active human C1 inhibitor serpin domain in Escherichia coli Protein Expr. Purif. 22 2001 349 358 (Pubitemid 32608562)
15. D. Liu, F. Lu, G. Qin, S.M. Fernandes, J. Li, and A.E. Davis 3rd. C1 inhibitor-mediated protection from sepsis J. Immunol. 179 2007 3966 3972
16. T. Nilsson, and B. Wiman Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s Eur. J. Biochem. 129 1983 663 667 (Pubitemid 13146276)
17. Y. Pilatte, C.H. Hammer, M.M. Frank, and L.F. Fries A new simplified procedure for C1 inhibitor purification. A novel use for jacalin-agarose J Immunol. Methods 120 1989 37 43 (Pubitemid 19144193)
18. R. Ramon, P. Ferrer, and F. Valero Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris J. Biotechnol. 130 2007 39 46 (Pubitemid 46634651)
19. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular Cloning: A Laboratory Manual 1989 Cold Spring Harbor New York, USA
20. R.B. Sim, G.J. Arlaud, and M.G. Colomb C1 inhibitor-dependent dissociation of human complement component C1 bound to immune complexes Biochem. J. 179 1979 449 457 (Pubitemid 9216092)
21. J. Sinha, B.A. Plantz, M. Inan, and M.M. Meagher Causes of proteolytic degradation of secreted recombinant proteins produced in methylotrophic yeast Pichia pastoris: Case study with recombinant ovine interferon-tau Biotechnol. Bioeng. 89 2005 102 112 (Pubitemid 40110988)
22. D. Storm, J. Herz, P. Trinder, and M. Loos C1 inhibitor-C1s complexes are internalized and degraded by the low density lipoprotein receptor-related protein J. Biol. Chem. 272 1997 31043 31050 (Pubitemid 27527551)
23. S. Thiel Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins Mol. Immunol. 44 2007 3875 3888 (Pubitemid 47337117)
24. M.W. Wolff, F. Zhang, J.J. Roberg, E.E. Caldwell, P.R. Kaul, J.N. Serrahn, D.W. Murhammer, R.J. Linhardt, and J.M. Weiler Expression of C1 esterase inhibitor by the baculovirus expression vector system: Preparation, purification, and characterization Protein Expr. Purif. 22 2001 414 421 (Pubitemid 32745332)
25. S. Wu, and G.J. Letchworth High efficiency transformation by electroporation of Pichia pastoris pretreated with lithium acetate and dithiothreitol Biotechniques 36 2004 152 154 (Pubitemid 38076393)
26. D. Wu, Y.Y. Hao, J. Chu, Y.P. Zhuang, and S.L. Zhang Inhibition of degradation and aggregation of recombinant human consensus interferon-alpha mutant expressed in Pichia pastoris with complex medium in bioreactor Appl. Microbiol. Biotechnol. 80 2008 1063 1071
27. W.A. Wuillemin, H. te Velthuis, Y.T. Lubbers, C.P. de Ruig, E. Eldering, and C.E. Hack Potentiation of C1 inhibitor by glycosaminoglycans: Dextran sulfate species are effective inhibitors of in vitro complement activation in plasma J. Immunol. 159 1997 1953 1960 (Pubitemid 127484185)
28. S. Zundel, S. Cseh, M. Lacroix, M.R. Dahl, M. Matsushita, J.P. Andrieu, W.J. Schwaeble, J.C. Jensenius, T. Fujita, G.J. Arlaud, and N.M. Thielens Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2 J. Immunol. 172 2004 4342 4350 (Pubitemid 38375249)