Design, synthesis and biological study of novel NO-donor-caffeic acid hybrids as potential anti-atherosclerotic drug candidates

Letters in Drug Design and Discovery

Volumn 8, Issue 6, 2011, Pages 550-557

  Li, Nian Guang ^a   Wang, Rong ^a   Tang, Yu Ping ^a   Shi, Zhi Hao ^b   Li, Bao Quan ^a   Li, Wei ^a   Yang, Jian Ping ^a   Wang, Zhen Jiang ^a   Song, Shu Lin ^a   Qian, Li Hua ^a   Yao, Li Juan ^a   Xi, Jun Zuan ^a   Xu, Jia ^a   Feng, Feng ^b   Qian, Da Wei ^a   Duan, Jin Ao ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antioxidant activity; Atherosclerosis; Caffeic acid; Nitric oxide donor; Nitric oxide release; Vasodilator activity

Indexed keywords

(4 PHENYL 1,2,5 OXADIAZOL 3 YL)METHYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 2 [4 (PHENYLSULFONYL) 1,2,5 OXADIAZOL 3 YLOXY]ETHYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 3 (NITROOXY)PROPYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 3 (NITROOXY)PROPYL 3 [4 [3 (NITROOXY)PROPOXY] 3 HYDROXYPHENYL]ACRYLATE; 3 [(4 PHENYL 1,2,5 OXADIAZOL 3 YL)METHOXY]BENZYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 3 [(4 PHENYL 1,2,5 OXADIAZOL 3 YL)METHOXY]PHENYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 4 (NITROOXY)BUTYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 4 (NITROOXY)BUTYL 3 [4 [4 (NITROOXY)BUTOXY] 3 HYDROXYPHENYL]ACRYLATE; 4 [(4 PHENYL 1,2,5 OXADIAZOL 3 YL)METHOXY]BENZYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 4 [(4 PHENYL 1,2,5 OXADIAZOL 3 YL)METHOXY]PHENYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 4 [4 (PHENYLSULFONYL) 1,2,5 OXADIAZOL 3 YLOXY]BUTAN 2 YL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 4 [4 (PHENYLSULFONYL) 1,2,5 OXADIAZOL 3 YLOXY]BUTYL 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; 5 (NITROOXY)PENTYL 3 [4 [5 (NITROOXY)PENTYLOXY] 3 HYDROXYPHENYL]ACRYLATE; 6 (NITROOXY)HEXYL 3 [4 [6(NITROOXY)HEXYLOXY] 3 HYDROXYPHENYL]ACRYLATE; [4 (NITROOXY)BUT 2 ENYL] 3 (3,4 DIHYDROXYPHENYL)ACRYLATE; ANTIOXIDANT; CAFFEIC ACID; ISOSORBIDE DINITRATE; NITRIC OXIDE DONOR; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG RELEASE; DRUG SYNTHESIS; FEMALE; ISOLATED ARTERY; LIPID PEROXIDATION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; VASODILATATION;

EID: 79959327463     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/157018011795906848     Document Type: Article

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