Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5199-5206

  Cena, Clara ^a   Chegaev, Konstantin ^a   Balbo, Silvia ^a   Lazzarato, Loretta ^a   Rolando, Barbara ^a   Giorgis, Marta ^a   Marini, Elisabetta ^a   Fruttero, Roberta ^a   Gasco, Alberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Multitarget drugs; NO donor antioxidants; NO donor ascorbic acid derivatives

Indexed keywords

4 (5,6 BISNITROOXYHEXYLOXY) 5 (1,2 DIHYDROXYETHYL) 3 HYDROXY 5H FURAN 2 ONE; 4 [2 (1,2 DIHYDROXYETHYL) 4 HYDROXY 5 OXO 2,5 DIHYDROFURAN 3 YLOXYMETHYL] FUROXAN 3 CARBOXYLIC ACID AMIDE; 4 [3 (3 PHENYLSULFONYLFUROXAN 4 YLOXY)PROPOXY] 5 (1,2 DIHYDROXYETHYL) 3 HYDROXY 5H FURAN 2 ONE; 5 (1,2 DIHYDROXYETHYL) 3 HYDROXY 4 (3 NITROOXYPROPOXY) 5H FURAN 2 ONE; 5 (1,2 DIHYDROXYETHYL) 3 HYDROXY 4 (6 NITROOXYHEXYLOXY) 5H FURAN 2 ONE; 5 (1,2 DIHYDROXYETHYL) 3 HYDROXY 4 [3 (3 PHENYLFUROXAN 4 YLOXY)PROPOXY] 5H FURAN 2 ONE; 5 (1,2 DIHYDROXYETHYL) 4 HYDROXY 3 (3 NITROOXYPROPOXY) 5H FURAN 2 ONE; 5 (1,2 DIHYDROXYETHYL) 4 HYDROXY 3 (6 NITROOXYHEXYLOXY) 5H FURAN 2 ONE; 5 (1,2 DIHYDROXYETHYL) 4 HYDROXY 3 [3 (3 PHENYLFUROXAN 4 YLOXY)PROPOXY] 5H FURAN 2 ONE; ANTIOXIDANT; ASCORBIC ACID; NITRIC OXIDE DONOR;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; IONIZATION; LIPID PEROXIDATION; LIPOPHILICITY; LIVER CELL; MICROSOME MEMBRANE; NONHUMAN; RAT; VASODILATATION;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; ASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPID PEROXIDATION; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICROSOMES; MOLECULAR STRUCTURE; NITRIC OXIDE DONORS; RATS; RATS, WISTAR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RATTUS;

EID: 43049085899     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.014     Document Type: Article

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