Study of thermo-sensitive in-situ gels for ocular delivery

Scientia Pharmaceutica

Volumn 79, Issue 2, 2011, Pages 351-358

  Bhowmik, Manas ^a   Das, Sanchita ^a   Chattopadhyay, Dipankar ^b   Ghosh, Lakshmi K ^a  

^a JADAVPUR UNIVERSITY   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

Hydroxypropylmethylcellulose; In situ gel; Methylcellulose; ORS

Indexed keywords

GLUCOSE; HYDROXYPROPYLMETHYLCELLULOSE; KETOROLAC TROMETAMOL; METHYLCELLULOSE; ORAL REHYDRATION SOLUTION;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; GEL; GELATION; IN VITRO STUDY; PHYSIOLOGY; TEMPERATURE DEPENDENCE; VISCOSITY;

EID: 79959318856     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: 10.3797/scipharm.1010-04     Document Type: Article

References (15)

1. Srividy B, Cardoza RM, Amin PD. Sustain ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. J Control Rel. 2001; 73: 205-211. doi:10.1016/S0168-3659(01)00279-6.
2. Bhowmik M, Bain MK, Ghosh LK, Chattopadhyay D. Effect of Salts on Gelation and Drug Release Profiles of Methylcellulose Based Ophthalmic Thermoreversible in-situ Gels. Pharm Dev Technol; in press. doi:10.3109/10837451003774369.
3. Schoenwald RD. Ocular drug delivery: pharmacokinetic considerations. Clin Pharmacokinet. 1990; 18: 255-269. doi:10.2165/00003088-199018040-00001.
4. Hongyi Q, Wenwen C, Chunyan H, Li L, Chuming C, Wenmin L, Chunjie W. Development of a poloxamer analogs/carbopol-based in-situ gelling and mucoadhesive ophthalmic delivery system for puerarin. Int J Pharm. 2007; 337: 178-187. doi:10.1016/j.ijpharm.2006.12.038.
5. Ridell A, Evertsson H, Nilsson S, Sundelof LO. Ampiphillic association of ibuprofen and two non ionic cellulose derivatives in aqueous solution. J Pharm Sci. 1999; 88: 1175-1181. doi:10.1021/js990092u
6. Bain MK, Bhowmik M, Maity D, Bera NK, Ghosh, SN, Chattopadhaya D. Control of Thermo Reversible Gelation of Methylcellulose Using Different Molecular Weight of PEG & NaCl for Sustain Delivery of Ophthalmic Drug. J Appl Polym Sci. 2010; 118: 631-637. doi:10.1002/app.32350.
7. Hsiue GH, Chang RW, Wang CH, Lee SH. Development of in situ thermosensitive drug vehicles for glaucoma therapy. Biomaterials. 2003; 24: 2423-2430. doi:10.1016/S0142-9612(03)00035-8.
8. Jeong B, Choi YK, Bae YH, Zentner G, Kim SW. New biodegradable polymers for injectable drug delivery systems. J Control Rel. 1999; 62: 109-114. doi:10.1016/S0168-3659(99)00061-9.
9. Qiu Y, Park K. Environmentally-sensitive polymer hydrogels. Adv Drug Deliv Rev. 2001; 53: 321-339. doi:10.1016/S0169-409X(01)00203-4.
10. Xu Y, Wang C, Tam KC, Li L. Salt-assisted and salt-suppressed sol-gel transitions of methylcellulose in water. Langmuir. 2004; 20: 646-652. doi:10.1021/la0356295.
11. Scherz W, Doane MG, Dohlman CH. Tears Volume in Normal Eye and Keratoconjunctivitis Sicca. Graefes Arch Klin Exp Ophthal. 1974; 192: 141-150. doi:10.1007/BF00410700.
12. th, CBS Publishers and Distributors, New Delhi, 2000, p:635.
13. th, Pharmaceutical Press: Great Britan, 2003, p:388.
14. Lin HR, Sung KC. Carbopol / Pluronic phase change solutions for ophthalmic drug delivery. J Control Rel. 2000; 69: 379-388. doi:S0168-3659(00)00329-1.
15. Rajinikanth PS, Balasubramaniam J, Mishra B. Development and evaluation of a novel floating in situ gelling system of amoxicillin for eradication of Helicobacter pylori. Int J Pharm. 2007; 335: 114-122. doi:10.1016/j.ijpharm.2006.11.008.