Development of in situ thermosensitive drug vehicles for glaucoma therapy

Biomaterials

Volumn 24, Issue 13, 2003, Pages 2423-2430

  Hsiue, Ging Ho ^a   Chang, Ru Wen ^a   Wang, Chau Hui ^a   Lee, Shih Huang ^b  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Controlled release; Glaucoma; Poly(2 hydroxyethyl methacrylate); Poly(N isopropylacrylamide); Thermosensitive polymers

Indexed keywords

DRUG THERAPY; ORGANIC POLYMERS; PRESSURE EFFECTS;

DRUG VEHICLES;

BIOMATERIALS;

ADRENALIN; ANTIGLAUCOMA AGENT; EYE DROPS; POLY(N ISOPROPYLACRYLAMIDE); POLYMACON;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CORNEA; CROSS LINKING; DRUG RELEASE; FEMALE; GLAUCOMA; HEAT SENSITIVITY; IN VIVO STUDY; INTRAOCULAR PRESSURE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; ROOM TEMPERATURE; TIME; TOPICAL TREATMENT;

EID: 0037409842     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(03)00035-8     Document Type: Article

References (15)

1. Chen G.H., Hoffman A.S. Graft-copolymers that exhibit temperature-induced phase-transitions over a wide-range of pH. Nature. 373:1995;49-52.
2. Park T.G., Hoffman A.S. Immobilization of arthrobacter-simplex in thermally reversible hydrogels - Effect of gel hydrophobicity on steroid conversion. Biotechnol Prog. 7:1991;383-390.
3. Tanaka T. Phase transitions in gels and a single polymer. Polymer. 20:1979;1404-1412.
4. Bae Y.H., Okano T., Hsu R., Kim S.W. Thermosensitive polymer as on-off switches for drug release. Makromol Chem Rapid Commun. 8:1987;481-485.
5. Okano T., Bae Y.H., Jacobs H., Kim S.W. Thermally on-off switching polymers for drug permeation and release. J Control Release. 11:1990;255-265.
6. Galaev I.Y., Mattiasson B. Thermoreactive water-soluble polymers, nonionic surfactants, and hydrogels as reagents in biotechnology. Enzyme Microb Technol. 15:1993;354-366.
7. Hoffman A.S. Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics. J Control Release. 6:1987;297-305.
8. Taylor L.D., Ceranowski L.D. Preparation of films exhibiting a balanced temperature dependence to permeation by aqueous solutions - A study of lower consolute behavior. J Polym Sci: Polym Chem Ed. 13:1975;2551-2570.
9. Hsiue G.H., Hsu S.H., Yang C.C., Lee S.H., Yang I.K. Preparation of controlled release ophthalmic drops, for glaucoma therapy using thermosensitive poly N-isopropylacrylamide. Biomaterials. 23:2002;457-462.
10. Chen G.H., Hoffman A.S. Temperature-induced phase-transition behaviors of random vs graft-copolymers of N-isopropylacrylamide and acrylic-acid. Macromol Rapid Commun. 16:1995;175-182.
11. Pelton R.H., Chibante P. Preparation of aqueous lattices with N-isopropylacrylamide. Colliods Surf. 20:1986;247-256.
12. Podual K., Doyle III F.J., Peppas N.A. Dynamic behavior of glucose oxidase-containing microparticles of poly(ethylene glycol)-grafted cationic hydrogels in an environment of changing pH. Biomaterials. 21:2000;1439-1450.
13. Feil H., Bae Y.H., Feijen J., Kim S.W. Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers. Macromolecules. 26:1993;2496-2500.
14. Peppas N.A. Analysis of fickian and non-fickian drug release from polymers. Pharm Acta Helv. 60:1985;110-111.
15. Alfrey T., Gurnee E.F., Lloyd W.G. Diffusion in glassy polymers. J Polym Sci: Part C. 12:1966;249-261.