Protein traffic is an intracellular target in alcohol toxicity

Pharmaceuticals

Volumn 4, Issue 5, 2011, Pages 741-757

  Esteban Pretel, Guillermo ^a   María, Marín Pilar ^a   Romero, Ana M ^a   Ponsoda, Xavier ^b   Ballestin, Raul ^b   Canales, Juan J ^c   Renau Piqueras, Jaime ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Astrocytes; Ethanol; Intracellular traffic; Neurons; Nucleocytoplasmic transport

Indexed keywords

ALCOHOL; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR T1; CLATHRIN; COAT PROTEIN COMPLEX I; COAT PROTEIN COMPLEX II; DYNAMIN; NERVE CELL ADHESION MOLECULE; NERVE GROWTH FACTOR; RAB PROTEIN; SNARE PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ALCOHOL ABUSE; ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOLIC BEVERAGE; ASTROCYTE; BRAIN CELL; CELL MIGRATION; CELL STRUCTURE; CYTOSKELETON; ENDOPLASMIC RETICULUM; EXOCYTOSIS; GLUCOSE TRANSPORT; GOLGI COMPLEX; HUMAN; LIVER CELL; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PROTEIN GLYCOSYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW; TARGET CELL; TRANS GOLGI NETWORK;

EID: 79959286619     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph4050741     Document Type: Review

References (92)

1. Derby, M.C.; Gleeson, P.A. New insights into membrane trafficking and protein sorting. Int. Rev. Cytol. 2007, 261, 47-116.
2. Jackson, C.L. Mechanisms of transport through the Golgi complex. J. Cell Sci. 2009, 122, 443-452.
3. Stephens, D.J.; Pepperkok, R. Imaging of procollagen transport reveals COPI-dependent cargo sorting during ER-to-Golgi transport in mammalian cells. J. Cell Sci. 2002, 115, 1149-1160.
4. van Vliet, C.; Thomas, E.C; Merino-Trigo, A.; Teasdale, R.D.; Gleeson, P.A. Intracellular sorting and transport of proteins. Prog. Biophys. Mol. Biol. 2003, 83, 1-45.
5. Hua, Z.; Graham T.R. The Golgi apparatus. In Trafficking Inside Cells: Pathways, Mechanisms and Regulation; Segev, N., Ed.; Landes Bioscience and Springer Science+Business Media, LLC: Boston, MA, USA, 2009; pp. 42-66.
6. J. Protein n-glycosylation along the secretory pathway: Relationship to organelle topography and function, protein quality control, and cell interactions. Chem. Rev. 2002, 102, 285-303.
7. Spiro, R.G. Protein glycosylation: Nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds. Glycobiology 2002, 12, 43R-56R.
8. Room, R.; Babor, T.; Rehm, J. Alcohol and public health. Lancet 2005, 365, 519-530.
9. Goodlett, C.R.; Horn, K.H. Mechanisms of alcohol-induced damage to the developing nervous system. Alcohol Res. Health 2001, 25, 175-184.
10. Streissguth, A.P.; O'Malley, K. Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. Semin. Clin. Neuropsychiatry 2000, 5, 177-190.
11. Sokol, R.J.; Delaney-Black, V.; Nordstrom, B. Fetal alcohol spectrum disorder. JAMA 2003, 290, 2996-2999.
12. May, P.A.; Gossage, J.P.; Kalberg, W.O.; Robinson, L.K.; Buckley, D.; Manning, M.; Hoyme, H.E. Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies. Dev. Disabil. Res. Rev. 2009, 15, 176-192.
13. Guerri, C.; Bazinet, A.; Riley, E.P. Fetal alcohol spectrum disorders and alterations in brain and behaviour. Alcohol Alcohol. 2009, 44, 108-114.
14. Martínez, S.E.; Egea, G. Novel molecular targets for the prevention of fetal alcohol syndrome. Recent Pat. CNS Drug Discov. 2007, 2, 23-35.
15. Braza-Boils, A.; Tomás, M.; Marín, M.P.; Megías, L.; Sancho-Tello, M.; Fornas, E.; Renau-Piqueras, J. Glycosylation is altered by ethanol in rat hippocampal cultures neurons. Alcohol Alcohol. 2006, 41, 494-504.
16. Marín, M.P.; Tomás, M.; Esteban-Pretel, G.; Megías, L.; López-Iglesias, C.; Egea, G.; Renau-Piqueras, J. Chronic ethanol exposure induces alterations in the nucleocytoplasmic transport in growing astrocytes. J. Neurochem. 2008, 106, 1914-1928.
17. Marín, M.P.; Esteban-Pretel, G.; Ponsoda, X.; Romero, A.M.; Ballestín, R.; López, C.; Megías, L.; Timoneda, T.; Molowny, A.; Canales, J.J.; et al. Endocytosis is altered by chronic alcohol exposure in cultured neurons. Toxicol. Sci. 2010, 115, 202-213.
18. Martínez, S.; Lázaro-Diéguez, F.; Selva, J.; Clavo, F.; Renau-Piqueras, J.; Crespo, P.; Claro, E.; Egea, G. Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol. J. Neurochem. 2007, 102, 1044-1052.
19. Tomás, M.; Fornas, E.; Megías, L.; Durán, J.M.; Portolés, M.; Guerri, C.; Egea, G.; Renau-Piqueras, J. Ethanol impairs monosaccharide uptake and glycosylation in cultured rat astrocytes. J. Neurochem. 2002, 83, 601-612.
20. Tomás, M.; Marín, P.; Megías, L.; Egea, G.; Renau-Piqueras, J. Ethanol perturbs the secretory pathway in astrocytes. Neurobiol. Dis. 2005, 20, 773-784.
21. Karinch, A.M.; Martin, J.H.; Vary, T.C. Acute and chronic ethanol consumption differentially impact pathways limiting hepatic protein synthesis. Am. J. Physiol. Endocrinol. Metab. 2008, 295, E3-E9.
22. Vallés, S.; Lindo, L.; Montolíu, C.; Renau-Piqueras, J.; Guerri, C. Prenatal exposure to ethanol induces changes in the nerve growth factor and its receptor in proliferating astrocytes in primary culture. Brain Res. 1994, 656, 281-286.
23. Miñana, R.; Climent, E.; Barettino, D.; Segui, J.M.; Renau-Piqueras, J.; Guerri, C. Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development. J. Neurochem. 2000, 75, 954-964.
24. Heaton, M.B.; Madorsky, I.; Paiva, M.; Siler-Marsiglio, K.I. Ethanol-induced reduction of neurotrophin secretion in neonatal rat cerebellar granule cells is mitigated by vitamin E. Neurosci. Lett. 2004, 370, 51-54.
25. Davis, M.I. Ethanol-BDNF interactions: still more questions than answers. Pharmacol. Ther. 2008, 118, 36-57.
26. Imperato, A.; di Chiara, G. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J. Pharmacol. Exp. Ther. 1986, 239, 219-228.
27. Luo, J.; Miller, M.W. Transforming growth factor beta1-regulated cell proliferation and expression of neural cell adhesion molecule in B104 neuroblastoma cells: differential effects of ethanol. J. Neurochem. 1999, 72, 2286-2293.
28. Baraona, E. Alcoholic hepatomegaly: accumulation of proteins in the liver. Science 1975, 190, 794-795.
29. Baraona, E.; Leo, M.; Borowsky, S.; Lieber, C. Pathogenesis of alcohol-induced accumulation of protein in the liver. J. Clinic. Invest. 1977, 60, 546-554.
30. Shepard, B.D.; Fernandez, D.J.; Tuma, P.L. Alcohol consumption impairs hepatic protein trafficking: mechanisms and consequences. Genes Nutr. 2010, 5, 129-140.
31. Stein, O.; Stein, Y. Visualization of intravenously injected 9, 10-3-H2-palmitic acid in rat liver by electronmicroscopic autoradiography. Isr. J. Med. Sci. 1966, 2, 239-242.
32. Stein, O.; Stein, Y. Lipid synthesis, intracellular transport, storage, and secretion. Electron microscopic radioautographic study of liver after injection of tritiated palmitate or glycerol in fasted and ethanol-treated rats. J. Cell Biol. 1967, 33, 319-339.
33. Larkin, J.M.; Oswald, B.; McNiven, M.A. Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein Rab2. J. Clin. Invest. 1996, 98, 2146-2157.
34. Ehrenreich, J.H.; Bergeron, J.J.; Siekevitz, P.; Palade, G.E. Golgi fractions prepared from rat liver homogenates. Isolation procedure and morphological characterization. J. Cell Biol. 1973, 59, 45-72.
35. Schwartz, T.U. Origins and evolution of cotranslational transport to the ER. In Eukaryotic Membranes and Cytoskeleton: Origins and Evolution; Jékely, G., Ed. Landes Bioscience and Springer Science+Business Media, LLC.: Boston, MA, USA. 2007; pp. 4-60.
36. Mitra, N.; Sinha, S.; Ramya, T.N.; Surolia, A. N-linked oligosaccharides as outfitters for glycoprotein folding, form and function. Trends Biochem. Sci. 2006, 31, 156-163.
37. Rasmussen, J.R. Effect of glycosylation on protein function. Curr. Opin. Struct. Biol. 1992, 2, 682-686.
38. Shental-Bechor, D.; Levy, Y. Folding of glycoproteins: Toward understanding the biophysics of the glycosylation code. Curr. Opin. Struct. Biol. 2009, 19, 524-533.
39. T. Carbohydrate-deficient transferrin as a marker of chronic alcohol abuse: A critical review of preanalysis, analysis, and interpretation. Clin. Chem. 2001, 47, 13-27.
40. Das, S.K.; Dhanya, L.; Vasudevan, D.M. Biomarkers of alcoholism: An updated review. Scand. J. Clin. Lab. Invest. 2008, 68, 81-92.
41. Cottalasso, D.; Gazzo, P.; Dapino, D.; Domenicotti, C.; Pronzato, M.A.; Traverso, N.; Bellocchio, A.; Nanni, G.; Marinari, U.M. Effect of chronic ethanol consumption on glycosylation processes in rat liver microsomes and Golgi apparatus. Alcohol Alcohol. 1996, 31, 51-59.
42. Ghosh, P.; Liu, Q.H.; Lakshman, M.R. Long-term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat liver. Metabolism 1995, 44, 890-898.
43. Guasch, R.; Renau-Piqueras, J.; Guerri, C. Chronic ethanol consumption induces accumulation of proteins in the liver Golgi apparatus and decreases galactosyltransferase activity. Alcohol. Clin. Exp. Res. 1992, 16, 942-948.
44. Azorín, I.; Portolés, M.; Marín, P.; Lázaro-Diéguez, F.; Megías, L.; Egea, G.; Renau-Piqueras, J. Prenatal ethanol exposure alters the cytoskeleton and induces glycoprotein microheterogeneity in rat newborn hepatocytes. Alcohol Alcohol. 2004, 39, 203-212.
45. Renau-Piqueras, J.; Guerri, C.; Sancho-Tello, M.; Báguena-Cervellera, R.; Miragall, F. Effects of prenatal exposure to ethanol on rat liver development. A review. Int. J. Dev. Biol. 1989, 33, 297-311.
46. Renau-Piqueras, J.; Sancho-Tello, J.; Báguena-Cervellera, R.; Guerri, C. Prenatal exposure to ethanol alters the synthesis and glycosylation of proteins in fetal hepatocytes. Alcohol. Clin. Exp. Res. 1989, 13, 817-823.
47. Renau-Piqueras, J.; Miragall, F.; Guerri, C.; Báguena-Cervellera, R. Prenatal exposure to alcohol alters the Golgi apparatus of newborn rat hepatocytes. A cytochemical study. J. Histochem. Cytochem. 1987, 35, 221-228.
48. Renau-Piqueras, J.; Guasch, R.; Azorín, I.; Seguí, J.M.; Guerri, C. Prenatal ethanol exposure affects galactosyltransferase activity and glycoconjugates in the Golgi apparatus of fetal rat hepatocytes. Hepatology 1997, 25, 343-350.
49. Fofana, B.; Yao, X.H.; Rampitsch, C.; Cloutier, S.; Wilkins, J.A.; Nyomba, B.L. Prenatal alcohol exposure alters phosphorylation and glycosylation of proteins in rat offspring liver. Proteomics 2010, 10, 417-434.
50. Omodeo-Salé, F.; Palestini, P. Chronic ethanol effects on glycoconjugates and glycosyl-transferases of rat brain. Alcohol 1994, 11, 301-306.
51. Hale, E.A.; Raza, S.K.; Ciecierski, R.G.; Ghosh, P. Deleterious actions of chronic ethanol treatment on the glycosylation of rat brain clusterin. Brain Res. 1998, 785, 158-166.
52. Azuine, M.A.; Patel, S.J.; Lakshman, M.R. Effects of chronic ethanol administration on the activities and relative synthetic rates of myelin and synaptosomal plasma membrane-associated sialidase in the rat brain. Neurochem. Int. 2006, 48, 67-74.
53. Lipscomb, B.W.; Treloar, H.B; Greer, C.A. Cell surface carbohydrates reveal heterogeneity in olfactory receptor cell axons in the mouse. Cell Tissue Res. 2002, 308, 7-17.
54. Ye, Z.; Marth, J.D. N-glycan branching requirement in neuronal and postnatal viability. Glycobiology 2004, 14, 547-558.
55. Miñana, R.; Climent, E.; Barettino, D.; Segui, J.M.; Renau-Piqueras, J.; Guerri, C. Alcohol exposure alters the expression pattern of neural cell adhesion molecules during brain development. J. Neurochem. 2000, 75, 954-964.
56. Roth, J.; Zuber, C.; Park, S.; Jang, I.; Lee, Y.; Kysela, K.G.; Le Fourn, V.; Santimaria, R.; Guhl, B.; Cho, J.W. Protein N-glycosylation, protein folding, and protein quality control. Mol. Cells 2010, 30, 497-506.
57. Török, N.; Marks, D.; Hsiao, K.; Oswald, B.J.; McNiven, M.A. Vesicle movement in rat hepatocytes is reduced by ethanol exposure: alterations in microtubule-based motor enzymes. Gastroenterology 1997, 113, 1938-1948.
58. Marmillot, P.; Rao, M.N.; Lakshman, M.R. Chronic ethanol exposure in rats affects rabs-dependent hepatic trafficking of apolipoprotein E and transferrin. Alcohol 2001, 25, 195-200.
59. Fletcher, D.A.; Mullins, R.D. Cell mechanics and the cytoskeleton. Nature 2010, 28, 485-492.
60. Iden, S.; Collard, J.G. Crosstalk between small GTPases and polarity proteins in cell polarization. Nat. Rev. Mol. Cell Biol. 2008, 9, 846-859.
61. Govek, E.E.; Newey, S.E.; van Aelst, L. The role of the Rho GTPases in neuronal development. Genes Dev. 2005, 19, 1-49.
62. Shepard, B.D.; Tuma, P.L. Alcohol-induced alterations of the hepatocyte cytoskeleton. World J. Gastroenterol. 2010, 16, 1358-1365.
63. Yoon, Y.; Török, N.; Krueger, E.; Oswald, B.; McNiven, M.A. Ethanol-induced alterations of the microtubule cytoskeleton in hepatocytes. Am. J. Physiol. 1998, 274, G757-G766.
64. 2+) transients, cell swelling and transformation of actin cytoskeleton in astroglial primary cultures. J. Neurochem. 2001, 76, 472-479.
65. Gonzalez, A.; Salido, G.M. Ethanol alters the physiology of neuron-glia communication. Int. Rev. Neurobiol. 2009, 88, 167-198.
66. Guasch, R.M.; Tomás, M.; Minambres, R.; Valles, S.; Renau-Piqueras, J.; Guerri, C. RhoA and lysophosphatidic acid are involved in the actin cytoskeleton reorganization of astrocytes exposed to ethanol. J. Neurosci. Res. 2003, 72, 487-502.
67. Renau-Piqueras, J.; Zaragozá, R.; de Paz, P.; Báguena-Cervellera, R.; Megías, L.; Guerri, C. Effects of prolonged ethanol exposure on the glial fibrillary acidic protein-containing intermediate filaments of astrocytes in primary culture: A quantitative immunofluorescence and immunogold electron microscopic study. J. Histochem. Cytochem. 1989, 37, 229-240.
68. Tomás, M.; Lázaro-Diéguez, F.; Durán, J.M.; Marín, P.; Renau-Piqueras, J.; Egea, G. Protective effects of lysophosphatidic acid (LPA) on chronic ethanol-induced injuries to the cytoskeleton and on glucose uptake in rat astrocytes. J. Neurochem. 2003, 87, 220-229.
69. Egea, G.; Lázaro-Dieguéz, F.; Vilella, M. Actin dynamics at the Golgi complex in mammalian cells. Curr. Opini. Cell Biol. 2006, 18, 168-178.
70. Egea, G.; Ríos R.M. The role of the cytoskeleton in the structure and function of the Golgi apparatus. In The Golgi Apparatus. State of the Art 110 years after Camilo Golgi's discovery; Minorov, A., Pavelka, M., Eds.; Springer Wien: New York, NY, USA, 2008; pp. 270-300.
71. Romero, A.M.; Esteban-Pretel, G.; Marín, M.P.; Ponsoda, X.; Ballestín, R.; Canales, J.J.; Renau-Piqueras, J. Chronic ethanol exposure alters the levels, assembly and cellular organization of the actin cytoskeleton and microtubules in hippocampal neurons in primary culture. Toxicol. Sci. 2010, 118, 602-612.
72. Sordella, R.; van Aelst, L. Driving actin dynamics under the influence of alcohol. Cell 2006, 127, 37-39.
73. McLane, J.A. Retrograde axonal transport in chronic ethanol-fed and thiamine-deficient rats. Alcohol. 1990, 7, 103-106.
74. McLane, J.A.; Atkinson, M.B.; McNulty, J.; Breuer, A.C. Direct measurement of fast axonal organelle transport in chronic ethanol-fed rats. Alcohol Clin. Exp. Res.1992, 6, 30-37.
75. Koike, H.; Sobue, G. Alcoholic neuropathy. Curr. Opin. Neurol. 2006, 19, 481-486.
76. Doherty, G.J.; McMahon, H.T. Mechanisms of endocytosis. Annu. Rev. Biochem. 2009, 78, 857-902.
77. Donaldson, J.G.; Porat-Shliom, N.; Cohen, L.A. Clathrin-independent endocytosis: A unique platform for cell signalling and PM remodeling. Cell. Signal. 2009, 21, 1-6.
78. Mayor, S.; Pagano, R.E. Pathways of clathrin-independent endocytosis. Nat. Rev. Mol. Cell Biol. 2007, 8, 603-612.
79. Fernandez, D.J.; McVicker, B.L.; Tuma, D.J.; Tuma, P.L. Ethanol selectively impairs clathrin-mediated internalization in polarized hepatic cells. Biochem. Pharmacol. 2009, 78, 648-655.
80. Megías, L.; Guerri, C.; Fornas, E.; Azorín, I.; Bendala, E.; Sancho-Tello, M.; Durán, J.M.; Tomás, M.; Gomez-Lechón, M.J.; Renau-Piqueras, J. Endocytosis and transcytosis in growing astrocytesin primary culture. Effect of ethanol and possible implications in neural development. Int. J. Dev. Biol. 2000, 44, 209-221.
81. Tomás, M.; Durán, J.M.; Lázaro-Diéguez, F.; Babia, T.; Renau-Piqueras, J.; Egea G. Fluorescent analogues of plasma membrane sphingolipids are sorted to different intracellular compartments in astrocytes. Harmful effects of chronic ethanol exposure on sphingolipid trafficking and metabolism. FEBS Lett. 2004, 563, 59-65.
82. Ballestín, R.; Molowny, A.; Marín, M.P.; Esteban-Pretel, G.; Romero, A.M.; López-García, C.; Renau-Piqueras, J.; Ponsoda, X. Ethanol reduces zincosome formation in cultured astrocytes. Alcohol Alcohol. 2011, 46, 17-25.
83. Methner, N.R.; Dayne Mayfield, R. Ethanol alters endosomal recycling of human dopamine transporters. J. Biol. Chem. 2010, 285, 10310-10317.
84. Hicklin, T.R.; Wu, P.H.; Radcliffe, R.A.; Freund, R.K.; Goebel-Goody, S.M.; Correa, P.R.; Proctor, W.R.; Lombroso, P.J.; Browning, M.D. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. Proc Natl Acad Sci U.S.A. 2011, 108, 6650-6655.
85. Roberto, M.; Treistman, S.N.; Pietrzykowski, A.Z.; Weiner, J.; Galindo, R.; Mameli, M.; Valenzuela, F.; Zhu, P.J.; Lovinger, D.; Zhang, T.A.; et al. Actions of acute and chronic ethanol on presynaptic terminals. Alcohol Clin. Exp. Res. 2006, 30, 222-232.
86. Wente, S.R.; Rout, M.P. The nuclear pore complex and nuclear transport. Cold Spring Harb. Perspect. Biol. 2010, 2, a000562.
87. Köser, J.; Maco, B.; Aebi, U.; Fahrenkrog, B. The nuclear pore complex becomes alive: New insights into its dynamics and involvement in different cellular processes. Atlas Genet. Cytogenet. Oncol. Haematol. 2005, 9, 347-382.
88. Michel, W.M. Nucleocytoplasmic shuttling signals: Two for the price of one. Trends Cell Biol. 2000, 10, 41-83.
89. Macara, I.G. Transport into and out of the nucleus. Microbiol. Mol. Biol. Rev. 2000, 65, 570-594.
90. Yoneda, Y. Nucleocytoplasmic protein traffic and its significance to cell function. Genes Cells 2001, 5, 777-787.
91. Andrade, J.P.; Cadete-Leite, A.; Paula-Barbosa, M.M.; Volk, B.; Tavares, M.A. Long-term alcohol consumption reduces the number of neuronal nuclear pores. A morphometric study undertaken in CA3 hippocampal pyramids of rats. Alcohol Clin. Exp. Res. 1988, 12, 286-289.
92. Strambio-De-Castillia, C.; Niepel, M.; Rout, M.P. The nuclear pore complex: Bridging nuclear transport and gene regulation. Nat. Rev. Mol. Cell Biol. 2010, 11, 490-501.