Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions

Neuropharmacology

Volumn 58, Issue 8, 2010, Pages 1189-1198

  Thyagarajan, Baskaran ^a   Potian, Joseph G ^a   Garcia, Carmen C ^a   Hognason, Kormakur ^a   Čapková, Kateřina ^b   Moe, Scott T ^c   Jacobson, Alan R ^c   Janda, Kim D ^b   McArdle, Joseph J ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c Absolute Science Inc   (United States)

Author keywords

Botulinum neurotoxin A; Hydroxamates; Metalloendoprotease inhibitors; Neuromuscular junction; Neuroparalysis; Neurotransmitter release

Indexed keywords

2,4 DICHLOROCINNAMIC ACID HYDROXAMIC ACID; ABS 130; BOTULINUM TOXIN A; CALCIUM ION; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOTULISM; CALCIUM CELL LEVEL; CHOLINERGIC NERVE CELL; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; ENDPLATE POTENTIAL; ENZYME INHIBITION; EVOKED RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MUSCLE FUNCTION; MUSCLE TONE; MUSCLE TWITCH; NERVE ENDING; NEUROMUSCULAR BLOCKING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE SENSITIVITY;

4-AMINOPYRIDINE; ACETYLCHOLINE; ANIMALS; ANTIDOTES; BOTULINUM TOXIN TYPE A; CALCIUM; CELL LINE, TUMOR; CINNAMATES; HYDROXAMIC ACIDS; METALLOEXOPEPTIDASES; MICE; MUSCLE CONTRACTION; MUSCLE, SKELETAL; NEUROMUSCULAR JUNCTION; REFLEX;

EID: 77952884035     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.02.014     Document Type: Article

References (23)

1. Adler M., Scovill J., Parker G., Lebeda F.J., Piotrowski J., Deshpande S.S. Antagonism of botulinum toxin-induced muscle weakness by 3,4-diaminopyridine in rat phrenic nerve-hemidiaphragm preparations. Toxicon 1995, 33:527-537.
2. Adler M., Macdonald D.A., Sellin L.C., Parker G.W. Effect of 3,4-diaminopyridine on rat extensor digitorum longus muscle paralyzed by local injection of botulinum neurotoxin. Toxicon 1996, 34:237-249.
3. Adler M., Capacio B., Deshpande S.S. Antagonism of botulinum toxin A-mediated muscle paralysis by 3,4-diaminopyridine delivered via osmotic minipumps. Toxicon 2000, 38:1381-1388.
4. Adler M., Keller J.E., Sheridan R.E., Deshpande S.S. Persistence of botulinum neurotoxin A demonstrated by sequential administration of serotypes A and E in rat EDL muscle. Toxicon 2001, 39:233-243.
5. Aiken S.P., Sellin L.C., Schmidt J.J., Weinstein S.A., McArdle J.J. A novel peptide toxin from Trimeresurus wagleri acts pre- and post-synaptically to block transmission at the rat neuromuscular junction. Pharmacol. Toxicol. 1992, 70:459-462.
6. Arnon S.S., Schechter R., Inglesby T.V., Henderson D.A., Bartlett J.G., Ascher M.S., Eitzen E., Fine A.D., Hauer J., Layton M., Lillibridge S., Osterholm M.T., O'Toole T., Parker G., Perl T.M., Russell P.K., Swerdlow D.L., Tonat K. Botulinum toxin as a biological weapon: medical and public health management. JAMA 2001, 285:1059-1070.
7. Boldt G.E., Eubanks L.M., Janda K.D. Identification of a botulinum neurotoxin A protease inhibitor displaying efficacy in a cellular model. Chem. Commun. (Camb.) 2006, 3063-3065.
8. Capkova K., Hixon M.S., McAllister L.A., Janda K.D. Toward the discovery of potent inhibitors of botulinum neurotoxin A: development of a robust LC MS based assay operational from low to subnanomolar enzyme concentrations. Chem. Commun. (Camb.) 2008, 3525-3527.
9. Cho S., Meriney S.D. The effects of presynaptic calcium channel modulation by roscovitine on transmitter release at the adult frog neuromuscular junction. Eur. J. Neurosci. 2006, 23:3200-3208.
10. Dolly O. Synaptic transmission: inhibition of neurotransmitter release by botulinum toxins. Headache 2003, 43(Suppl. 1):S16-S24.
11. Eubanks L.M., Hixon M.S., Jin W., Hong S., Clancy C.M., Tepp W.H., Baldwin M.R., Malizio C.J., Goodnough M.C., Barbieri J.T., Johnson E.A., Boger D.L., Dickerson T.J., Janda K.D. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proc. Natl. Acad. Sci. USA 2007, 104:2602-2607.
12. Fischer A., Nakai Y., Eubanks L.M., Clancy C.M., Tepp W.H., Pellett S., Dickerson T.J., Johnson E.A., Janda K.D., Montal M. Bimodal modulation of the botulinum neurotoxin protein-conducting channel. Proc. Natl. Acad. Sci. USA 2009, 106:1330-1335.
13. Keller J.E., Neale E.A. The role of the synaptic protein SNAP-25 in the potency of botulinum neurotoxin type A. J. Biol. Chem. 2001, 276:13476-13482.
14. McArdle J.J., Angaut-Petit D., Mallart A., Bournaud R., Faille L., Brigant J.L. Advantages of the triangularis sterni muscle of the mouse for investigations of synaptic phenomena. J. Neurosci. Methods 1981, 4:109-115.
15. McArdle, J.J., Potian, J.G., Hognason, K., Lebeda, F. and Schmidt, J.J., 2007. Peptide inhibitors of botulinum neurotoxin A zinc metalloendoprotease as therapeutic agents. Abstract presented at Interagency botulinum Research Coordinating Committee Meeting, Oct 14-18, 2007, Asilomar Conference Ground, CA.
16. Montal M.S., Blewitt R., Tomich J.M., Montal M. Identification of an ion channel-forming motif in the primary structure of tetanus and botulinum neurotoxins. FEBS Lett. 1992, 313:12-18.
17. Montecucco C., Papini E., Schiavo G. Bacterial protein toxins penetrate cells via a four-step mechanism. FEBS Lett. 1994, 346:92-98.
18. Montecucco C. How do tetanus and botulinum toxins bind to neuronal membranes?. Trends Biochem. Sci. 1986, 11:314-317.
19. Rogozhin A.A., Pang K.K., Bukharaeva E., Young C., Slater C.R. Recovery of mouse neuromuscular junctions from single and repeated injections of botulinum neurotoxin A. J. Physiol. 2008, 586:3163-3182.
20. Schmidt J.J., Stafford R.G. A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity. FEBS Lett. 2002, 532:423-426.
21. Simpson L.L. The interaction between aminoquinolines and presynaptically acting neurotoxins. J. Pharmacol. Exp. Ther. 1982, 222:43-48.
22. Souayah N., Karim H., Kamin S.S., McArdle J., Marcus S. Severe botulism after focal injection of botulinum toxin. Neurology 2006, 67:1855-1856.
23. Thyagarajan B., Krivitskaya N., Potian J.G., Hognason K., Garcia C.C., McArdle J.J. Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin A. J. Pharmacol. Exp. Ther. 2009, 331:361-371.