Dermatan sulfate interacts with dead cells and regulates CD5+ B-cell fate: Implications for a key role in autoimmunity

American Journal of Pathology

Volumn 178, Issue 5, 2011, Pages 2168-2176

  Wang, Julia Y ^a   Lee, Jongmin ^a   Yan, Ming ^a   Rho, Jung Hyun ^a   Roehrl, Michael H A ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIGEN; DERMATAN SULFATE; IMMUNOGLOBULIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY RESPONSE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; B 1A LYMPHOCYTE; B LYMPHOCYTE; CELL FATE; CONTROLLED STUDY; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOLECULAR CLONING; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

EID: 79959277719     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.01.028     Document Type: Article

References (23)

1. Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF: B-lymphocyte contributions to human autoimmune disease. Immunol Rev 2008, 223:284-299 (Pubitemid 351986191)
2. Berland R, Wortis HH: Origins and functions of B-1 cells with notes on the role of CD5. Annu Rev Immunol 2002, 20:253-300 (Pubitemid 34293426)
3. Hardy RR: B-1 B cells: development, selection, natural autoantibody and leukemia. Curr Opin Immunol 2006, 18:547-555
4. Duan B, Morel L: Role of B-1a cells in autoimmunity. Autoimmun Rev 2006, 5:403-408 (Pubitemid 44143033)
5. Ishida D, Su L, Tamura A, Katayama Y, Kawai Y, Wang SF, Taniwaki M, Hamazaki Y, Hattori M, Minato N: Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells. Immunity 2006, 24:417-427
6. Pao LI, Lam KP, Henderson JM, Kutok JL, Alimzhanov M, Nitschke L, Thomas ML, Neel BG, Rajewsky K: B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity. Immunity 2007, 27:35-48 (Pubitemid 47089020)
7. Trowbridge JM, Gallo RL: Dermatan sulfate: new functions from an old glycosaminoglycan. Glycobiology 2002, 12:117R-125R
8. Rho J, Zhang W, Murali M, Roehrl MHA, Wang JY: Human proteins with affinity for dermatan sulfate have the propensity to become autoantigens. Am J Pathol 2011, 178:2177-2190
9. Kruisbeek AM: Isolation of mouse mononuclear cells. Curr Protoc Immunol 2001, Unit 3.1
10. Aulinger BA, Roehrl MH, Mekalanos JJ, Collier RJ, Wang JY: Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun 2005, 73:3408-3414 (Pubitemid 40745883)
11. Yan M, Roehrl MH, Basar E, Wang JY: Selection and evaluation of the immunogenicity of protective antigen mutants as anthrax vaccine candidates. Vaccine 2008, 26:947-955
12. Choi YH, Roehrl MH, Kasper DL, Wang JY: A unique structural pattern shared by T-cell-activating and abscess-regulating zwitterionic polysaccharides. Biochemistry 2002, 41:15144-15151 (Pubitemid 36008122)
13. Rhie GE, Roehrl MH, Mourez M, Collier RJ, Mekalanos JJ, Wang JY: A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A 2003, 100:10925-10930 (Pubitemid 37140129)
14. Wang JY, Roehrl MH: Glycosaminoglycans are a potential cause of rheumatoid arthritis. Proc Natl Acad Sci U S A 2002, 99:14362-14367 (Pubitemid 35257677)
15. Aoyama E, Yoshihara R, Tai A, Yamamoto I, Gohda E: PKC- and PI3K-dependent but ERK-independent proliferation of murine splenic B cells stimulated by chondroitin sulfate B. Immunol Lett 2005, 99: 80-84 (Pubitemid 40718937)
16. Yoshihara R, Aoyama E, Kadota Y, Kawai S, Goto T, Zhong M, Gohda E: Differentiation of murine B cells induced by chondroitin sulfate B. Cell Immunol 2007, 250:14-23
17. Rickert RC, Rajewsky K, Roes J: Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 1995, 376:352-355
18. de Fougerolles AR, Batista F, Johnsson E, Fearon DT: IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19. Eur J Immunol 2001, 31:2189-2199 (Pubitemid 32640736)
19. Sato S, Ono N, Steeber DA, Pisetsky DS, Tedder TF: CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. J Immunol 1996, 157:4371-4378 (Pubitemid 126449355)
20. Culton DA, Nicholas MW, Bunch DO, Zhen QL, Kepler TB, Dooley MA, Mohan C, Nachman PH, Clarke SH: Similar CD19 dysregulation in two autoantibody- associated autoimmune diseases suggests a shared mechanism of B-cell tolerance loss. J Clin Immunol 2007, 27:53-68 (Pubitemid 46224934)
21. Casciola-Rosen LA, Anhalt G, Rosen A: Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994, 179: 1317-1330 (Pubitemid 24091790)
22. Plotz PH: The autoantibody repertoire: searching for order. Nat Rev Immunol 2003, 3:73-78
23. Mond JJ, Lees A, Snapper CM: T cell-independent antigens type 2. Annu Rev Immunol 1995, 13:655-692