Disubstituted bis-THF moieties as new P2 ligands in nonpeptidal HIV-1 protease inhibitors

ACS Medicinal Chemistry Letters

Volumn 2, Issue 6, 2011, Pages 461-465

  Hohlfeld, Konrad ^a   Tomassi, Cyrille ^a   Wegner, Jörg Kurt ^b   Kesteleyn, Bart ^b   Linclau, Bruno ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b Tibotec   (Belgium)

Author keywords

bis THF bis diol; darunavir; HIV protease; inhibitors

Indexed keywords

ATAZANAVIR; DARUNAVIR; LIGAND; LOPINAVIR; PROTEINASE INHIBITOR; TETRAHYDROFURAN DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT; VIRUS MUTATION; WILD TYPE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79959276692     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2000356     Document Type: Article

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