Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging

Clinical Nutrition

Volumn 24, Issue 5, 2005, Pages 794-800

  Savitha, S ^a   Sivarajan, K ^a   Haripriya, D ^a   Kokilavani, V ^a   Panneerselvam, C ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Aging; Carnitine; Electron transport chain; Lipoic acid; Mitochondria; Tricarboxylic acid cycle

Indexed keywords

CARNITINE; CYTOCHROME C OXIDASE; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; MULTIENZYME COMPLEX; OXOGLUTARATE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); THIOCTIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CITRIC ACID CYCLE; CONTROLLED STUDY; DRUG EFFICACY; ENERGY YIELD; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; HEART MITOCHONDRION; MALE; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; NONHUMAN; RAT; RAT STRAIN;

AGE FACTORS; AGING; ANIMALS; CARNITINE; CITRIC ACID CYCLE; ELECTRON TRANSPORT COMPLEX IV; ISOCITRATE DEHYDROGENASE; KETOGLUTARATE DEHYDROGENASE COMPLEX; MALATE DEHYDROGENASE; MALE; MITOCHONDRIA, HEART; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE; THIOCTIC ACID; TREATMENT OUTCOME; VITAMIN B COMPLEX;

EID: 26044471868     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2005.04.005     Document Type: Article

References (39)

1. D. Harman Aging: At theory based on free radical and radiation chemistry J Gerontol 2 1956 298-300
2. D. Harman Free radical theory of aging Mutation Res 275 1992 257-266
3. B. Beckman B.N. Ames The free radical theory of aging matures Physiol Rev 78 1998 547-581
4. E. Cadenas K.J. Davies Mitochondrial free radical generation, oxidative stress and aging Free Radical Biol Med 29 2000 222-230
5. C. Muscari A. Giaccari E. Giorano C. Clo C. Guarnieri C.M. Caldarera Role of reactive oxygen species in cardiovascular aging Mol Cell Biochem 160-161 1996 159-166
6. E.J. Lesnefsky S. Moghaddas B. Tandler J. Kerner C.L. Hoppel Mitochondria dysfunction in cardiac disease: Ischemia - reperfusion, aging and heart failure J Mol Cell Cardiol 33 2001 1065-1089
7. T.M. Hagen R. Moreau J.H. Suh F. Violi Mitochondrial decay in the aging rat heart; evidence for improvement by dietary supplementation with acetyl-L - carnitine and/or lipoic acid FASEB J 15 2001 700-706
8. K.L. Goa R.N. Brogden L-Carnitine Drugs 34 1987 1-24
9. T.M. Hagen R.T. Ingersoll C.M. Wehr et al. Acetyl-L-Carnitine fed to old rats partially restores mitochondrial function and ambulatory activity Proc Nat Acad Sci USA 95 1998 9562-9566
10. S. Savitha J. Tamilselvan M. Anusuya devi C. Panneerselvam Oxidative stress on mitochondrial antioxidant defence system in aging process: Role of DL-α -lipoic acid and L-Carnitine Clin Chim Acta 355 2005 173-180
11. N. Haramaki D. Han G.J. Handelman H.J. Tritschler L. Packer Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of α -lipoic acid Free Radical Res Med 22 1997 535-542
12. S. Roy L. Packer Redox regulation of cell functions by α -lipoate: biochemical and molecular aspects Biofactors 7 1998 263-267
13. J. Bustamante J.K. Lodge L. Marcocci H.J. Tritschler L. Packer B.H. Rihn α -lipoic acid in liver metabolism and disease Free Radical Biol Med 24 1998 1023-1039
14. M. Takasawa M. Hayakawa S. Sugiyama K. Hattori T. Ito T. Ozawa Age associated damage in mitochondrial function in rat hearts Exp Gerontol 28 1993 269-280
15. O.H. Lowry N.J. Rosenbrough A.L. Farr R.J. Randall Protein measurement with the Folin-phenol reagent J Biol Chem 193 1951 351-358
16. J. King The dehydrogenase or oxidorectases-lactate dehydrogenase In: D. Van editor. Practical clinical enzymology 1965 Nostrand company limited London 83-93
17. L.J. Reed B.B. Mukherjee α -KG dehydrogenase complex from Escherichia coli Methods Enzymol 13 1969 55-61
18. E.C. Slater W.D. Bonnner The effect of fluoride on succinate oxidase system Biochem J 52 1952 185-196
19. S. Ochoa Malic dehydrogenase from pig heart In: S.P. Colowick N.O. Kaplan editors. Methods Enzymol 1955 Academic Press Inc. New York and London 735-739
20. M. Brich-Machin H.L. Briggs A.A. Saborida L.A. Bingoff D.M. Turnbull An evaluation of the measurement of the activities of complex I-IV in the respiratory chain of human skeletal muscle mitochondria Biochem Med Metab Biol 51 1994 35-42
21. S. Krahenbuhl C. Talos U. Wiesman C.L. Hoppel Development and evaluation of a spectrophotometric assay for complex III in isolated mitochondria, tissue and fibroblast from rats and humans Clin Chim Acta 230 1994 177-187
22. L. Smith Spectrophotometric assay of cytochrome c oxidase Methods Biochem Anal 2 1995 427-434
23. D. Harman The biological clock: The mitochondria? J Am Geriatr Soc 20 1972 145-147
24. S.W. Fannin E.J. Lesnefsky T.J. Slabe M.O. Hassan C.L. Hoppel Aging selectively decreases oxidative capacity in rat heart interfibrillary mitochondria Arch Biochem Biophys 372 1999 399-407
25. R. Hansford F. Castrol Age-linked changes in the activity of enzymes of the tricarboxylic acid cycle and lipid oxidation, and of carnitine content, in muscles of the rat Mech Ageing Dev 19 1982 191-200
26. J.B. McMillin G.E. Taffet H. Taegtmeyer E.K. Hudson C.A. Tate Mitochondrial metabolism and substrate competition in the aging Fischer rat heart Cardiovasc Res 27 1993 2222-2228
27. D. Haripriya M. Anusuya Devi V. Kokilavani P. Sangeetha C. Panneerselvam Age-dependent alterations in mitochondrial enzymes in cortex, striatum and hippocampus of rat brain-potential role of L-Carnitine Biogerontol 5 2004 355-364
28. A. Arivazhagan K. Ramanathan C. Panneerselvam Effect of DL-α-lipoic acid on mitochondrial enzymes in aged rats Chem Biol Inter 138 2001 189-198
29. L. Packer H.J. Tritschler K. Wessel Neuroprotection by the metabolic antioxidant α -lipoic acid Free Radical Boil Med 22 1997 359-378
30. L. Packer E.H. Witt H.J. Tritschler Alpha-lipoic acid as a biological antioxidant Free Radical Biol Med 19 1995 227-250
31. C. Castelluccio A. Baracca R. Fato et al. Mitochondrial activities of rat heart during aging Mech Ageing Dev 79 1994 73-88
32. S. Kumaran S. Savitha M. Anusuya Devi C. Panneerselvam L-Carnitine and DL- α Lipoic acid reverses the age-related deficit in glutathione redox state in skeletal muscle and heart tissues Mech Ageing Dev 125 2004 507-512
33. P. Mecocci M.F. Beal R. Cecchetti et al. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain Mol Chem Neuropathol 31 1997 53-64
34. J. Muller-Hocker S. Schafer T.A. Link S. Possekel C. Hammer Defects of the respiratory chain in various tissues of old monkeys: A cytochemical-immunocytochemical study Mech Ageing Dev 86 1996 197-213
35. G.M. Abu-Erreish D.R. Sanadi Age related changes in cytochrome concentration of myocardial mitochondria Mech Ageing Dev 7 1978 425-432
36. G. Paradies F.M. Ruggiero G. Petrosillo E. Quagliariello Age-dependent decrease in the cytochrome c oxidase activity and changes in phopholipids in rat heart mitochondria Arch Gerontol Geriar 16 1993 263-272
37. M.K. Shigenaga T.M. Hagen B.N. Ames Oxidative damage and mitochondrial decay in aging Proc Natl Acad Sci USA 91 1994 10771-10778
38. A. Cormio A.M. Lezza J. Vecchiet et al. MtDNA deletions in aging and in nonmitochondrial pathologies Ann NY Acad Sci 908 2000 299-301
39. G.A. Cortopassi N. Arnheim Detection of a specific mitochondria DNA deletions in tissues of older humans Nucleic Acid Res 18 1990 6927-6933