Gene-expression profile analysis in the mid-gestation human intestine discloses greater functional immaturity of the colon as compared with the ileum

Journal of Pediatric Gastroenterology and Nutrition

Volumn 52, Issue 6, 2011, Pages 670-678

  Tremblay, Eric ^a   Ferretti, Emanuela ^b   Babakissa, Corentin ^c   Seidman, Ernest G ^d   Levy, Emile ^e   Ménard, Daniel ^a   Beaulieu, Jean François ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Colon; digestive functions; gene expression; mid gestation; premature; small intestine

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; ACTIN; ADAM10 ENDOPEPTIDASE; AQUAPORIN 3; ARGININE; BETA 2 MICROGLOBULIN; CXCL9 CHEMOKINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EPHRIN RECEPTOR; EPITHELIAL SODIUM CHANNEL; GLYCINE; JAGGED1; MYC PROTEIN; MYOSIN VI; ORNITHINE OXOACID AMINOTRANSFERASE; PHENYLALANINE; PROLINE; PROTEIN 14 3 3; PROTEIN P53; RAC1 PROTEIN; RETINOBLASTOMA BINDING PROTEIN 4; SERINE; SIRTUIN 3; SODIUM PROTON EXCHANGE PROTEIN 3; SUCRASE ISOMALTASE; THREONINE; TYROSINE; UNINDEXED DRUG; VON WILLEBRAND FACTOR;

ADULT; AMINO ACID METABOLISM; ARTICLE; CELL CYCLE; CELL DEATH; CELL STRUCTURE; COLON; COMPUTER PROGRAM; FETUS; GENE; GENE EXPRESSION; GESTATIONAL AGE; HUMAN; ILEUM; IMMATURITY; INGENUITY PATHWAY ANALYSIS SOFTWARE; MICROARRAY ANALYSIS; MINERAL METABOLISM; PRIORITY JOURNAL; VITAMIN METABOLISM;

CELL CYCLE; CELL DEATH; CLUSTER ANALYSIS; COLON; DNA, COMPLEMENTARY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; ILEUM; MICROARRAY ANALYSIS; SIGNAL TRANSDUCTION;

EID: 79959265013     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3182078370     Document Type: Article

References (48)

1. Henning SJ. Postnatal development: coordination of feeding, digestion, and metabolism. Am J Physiol 1981;241:G199-214.
2. Ménard D, Calvert R. Fetal and Postnatal Development ofthe Small and Large Intestine: Patterns and Regulation. Boca Raton, FL: CRC Press; 1991.
3. Menard D. Functional development of the human gastrointestinal tract: hormone-and growth factor-mediated regulatory mechanisms. Can J Gastroenterol 2004;18:39-44. (Pubitemid 38292224)
4. Montgomery RK, Mulberg AE, Grand RJ. Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 1999;116:702-31. (Pubitemid 29106779)
5. Ménard D. Growth-promoting Factors and the Development of the Human Gut. New York: Raven Press; 1989.
6. Ménard D, Beaulieu JF. Human Intestinal Brush Border Membrane Hydrolases. Norwell: Kluwer Academic; 1994.
7. Levy E, Menard D. Developmental aspects of lipid and lipoprotein synthesisand secretion in human gut. Microsc Res Tech2000;49:363-73. (Pubitemid 30407772)
8. Auricchio S, Stellato A, De Vizia B. Development of brush border peptidases in human and rat small intestine during fetal and neonatal life. Pediatr Res 1981;15:991-5. (Pubitemid 11087044)
9. Menard D, Pothier P. Differential distribution of digestive enzymes in isolated epithelial cells from developing human fetal small intestine and colon. J Pediatr Gastroenterol Nutr 1987;6:509-16. (Pubitemid 17085183)
10. Sebastio G, Hunziker W, O'Neill B, et al. The biosynthesis of intestinal sucrase-isomaltase in human embryo is most likely controlled at the level of transcription. Biochem Biophys Res Commun 1987;149:830-9. (Pubitemid 18023053)
11. Basque JR, Levy E, Beaulieu JF, et al. Apolipoproteins in human fetal colon: immunolocalization, biogenesis, and hormonal regulation. J Cell Biochem 1998;70:354-65. (Pubitemid 28355589)
12. Levy E, Loirdighi N, Thibault L, et al. Lipid processing and lipoprotein synthesis by the developing human fetal colon. Am J Physiol 1996; 270:G813-20.
13. Raul F, Lacroix B, Aprahamian M. Longitudinal distribution of brush border hydrolases and morphological maturation in the intestine of the preterm infant. Early Hum Dev 1986;13:225-34. (Pubitemid 16107062)
14. Caicedo RA, Schanler RJ, Li N, et al. The developing intestinal ecosystem: implications for the neonate. Pediatr Res 2005;58:625-8. (Pubitemid 41368887)
15. Kliegman RM. The relationship of neonatal feeding practices and the pathogenesis and prevention of necrotizing enterocolitis. Pediatrics 2003;111:671-2. (Pubitemid 36330729)
16. Neu J, Caicedo RA, Schanler RJ, et al. Neonatal necrotizing enter-ocolitis: an update. Acta Paediatr Suppl 2005;94:100-5.
17. Fell JM. Neonatal inflammatory intestinal diseases: necrotising enter-ocolitis and allergic colitis. Early Hum Dev 2005;81:117-22. (Pubitemid 40221989)
18. Nanthakumar NN, Fusunyan RD, Sanderson I, et al. Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis. Proc Natl Acad Sci USA 2000;97:6043-8. (Pubitemid 30367520)
19. Hoehn T, Stover B, Buhrer C Colonic pneumatosis intestinalis in preterm infants: different to necrotising enterocolitis with a more benign course? Eur J Pediatr 2001;160:369-71. (Pubitemid 32449149)
20. Leonidas JC, Hall RT Neonatal pneumatosis coli: a mild form of neonatal necrotizing enterocolitis. J Pediatr 1976;89:456-9.
21. Travadi JN, Patole SK, Gardiner K. Pneumatosis coli, a benign form of necrotising enterocolitis. Indian Pediatr 2003;40:349-51. (Pubitemid 36505617)
22. Nanthakumar NN, Young C, Ko JS, et al. Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis.Am J Physiol Gastrointest Liver Physiol 2005;288:G85-92. (Pubitemid 39665223)
23. Amin HJ, Zamora SA, McMillan DD, et al. Arginine supplementation prevents necrotizing enterocolitis in the premature infant. J Pediatr 2002;140:425-31. (Pubitemid 34494314)
24. Di Lorenzo M, Bass J, Krantis A. Use of L-arginine in the treatment of experimental necrotizing enterocolitis. JPediatr Surg 1995;30:235-40.
25. Clark JA, Doelle SM, Halpern MD, et al. Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treat-ment. Am J Physiol Gastrointest Liver Physiol 2006;291:G938-49. (Pubitemid 44772020)
26. Nair RR, Warner BB, Warner BW. Role of epidermal growth factor and other growth factors in the prevention of necrotizing enterocolitis. Semin Perinatol 2008;32:107-13. (Pubitemid 351381169)
27. Tremblay E, Auclair J, Delvin E, et al. Gene expression profiles of normal proliferating and differentiating human intestinal epithelial cells: a comparison with the Caco-2 cell model. J Cell Biochem 2006; 99:1175-86. (Pubitemid 44673973)
28. Saeed AI, Sharov V, White J, et al. TM4: a free, open-source system for microarray data management and analysis. Biotechniques 2003;34: 374-8. (Pubitemid 36184095)
29. Dydensborg AB, Herring E, Auclair J, et al. Normalizing genes for quantitative RT-PCR in differentiating human intestinal epithelial cells and adenocarcinomas of the colon. Am J Physiol Gastrointest Liver Physiol 2006;290:G1067-74.
30. Pfaffl MW, Tichopad A, Prgomet C, et al. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations. Biotechnol Lett 2004;26:509-15. (Pubitemid 38448421)
31. Commare CE, Tappenden KA. Development of the infant intestine: implications for nutrition support. Nutr Clin Pract 2007;22:159-73.
32. Neu J. Gastrointestinal development and meeting the nutritional needs of premature infants. Am J Clin Nutr 2007;85:629S-34S. (Pubitemid 46220974)
33. Mariadason JM, Nicholas C, LItalien KE, et al. Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis. Gastroenterology 2005;128:1081-8. (Pubitemid 40523558)
34. Stegmann A, Hansen M, Wang Y, et al. Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation. Physiol Genomics 2006;27:141-55. (Pubitemid 46705407)
35. Zamora SA, Amin HJ, McMillan DD, et al. Plasma L-arginine con-centrations in premature infants with necrotizing enterocolitis. J Pediatr 1997;131:226-32. (Pubitemid 27495241)
36. Becker RM, Wu G, Galanko JA, et al. Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr 2000; 137:785-93.
37. Kohler ES, Sankaranarayanan S, van Ginneken CJ, et al. The human neonatal small intestine has the potential for arginine synthesis; devel-opmental changes in the expression of arginine-synthesizing and-catabolizing enzymes. BMC Dev Biol 2008;8:107.
38. Wu G. Synthesis of citrulline and arginine fromproline in enterocytes of postnatal pigs. Am J Physiol 1997;272:G1382-90.
39. Wu G, Meininger CJ, Knabe DA, et al. Arginine nutrition in develop-ment, health and disease. Curr Opin Clin Nutr Metab Care 2000;3: 59-66. (Pubitemid 30469106)
40. Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 1998;336(pt 1):1-17. (Pubitemid 28532555)
41. Bertolo RF, Brunton JA, Pencharz PB, et al. Arginine, ornithine, and proline interconversion is dependent on small intestinal metabolism in neonatal pigs. Am J Physiol Endocrinol Metab 2003;284:E915-22. (Pubitemid 36444026)
42. Desloges N, Simoneau A, Jutras S, et al. Tenascin may not be required for intestinal villus development. Int J Dev Biol 1994;38:737-9.
43. Lussier C, Sodek J, Beaulieu JF Expression of SPARC/osteonectin/BM4O in the human gut: predominance in the stroma of the remodeling distal intestine. J Cell Biochem 2001;81:463-76. (Pubitemid 32405764)
44. Vachon PH, Cardin E, Harnois C, et al. Early acquisition of bowel segment-specific Bcl-2 homolog expression profiles during development of the human ileum and colon. Histol Histopathol 2001;16:497-510. (Pubitemid 32297648)
45. Arsenault P, Menard D. Influence of hydrocortisone on human fetal small intestine in organ culture. J Pediatr Gastroenterol Nutr 1985; 4:893-901. (Pubitemid 16192451)
46. Menard D, Corriveau L, Arsenault P. Differential effects of epidermal growth factor and hydrocortisone in human fetal colon. J Pediatr Gastroenterol Nutr 1990;10:13-20. (Pubitemid 20018100)
47. Menard D, Arsenault P, Pothier P. Biologic effects of epidermal growth factor in human fetal jejunum. Gastroenterology 1988;94:656-63. (Pubitemid 18073525)
48. Schjoldager KT, Maltesen HR, Balmer S, et al. Cellular cross talk in the small intestinal mucosa: postnatal lymphocytic immigration elicits a specific epithelial transcriptional response. Am J Physiol Gastrointest Liver Physiol 2008;294:G1335-43.