Control of the heparosan N-deacetylation leads to an improved bioengineered heparin

Applied Microbiology and Biotechnology

Volumn 91, Issue 1, 2011, Pages 91-99

  Wang, Zhenyu ^a   Yang, Bo ^b   Zhang, Zhenqing ^b   Ly, Mellisa ^b   Takieddin, Majde ^c   Mousa, Shaker ^c   Liu, Jian ^d   Dordick, Jonathan S ^a   Linhardt, Robert J ^a,b  

^a RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

^c ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^d University of North Carolina   (United States)

Author keywords

Deacetylation; Heparin; Heparosan; Porcine intestine

Indexed keywords

ANIMAL VIRUS; ANTI-COAGULANT DRUGS; ANTICOAGULANT ACTIVITIES; COMMERCIAL PRODUCTIONS; DEACETYLATION; ENZYMATIC MODIFICATION; EPIMERIZATION; GLYCOSAMINOGLYCANS; HEPARIN; HEPAROSAN; IDURONIC ACID; INTESTINAL MUCOSA; N-ACETYLGLUCOSAMINE; N-DEACETYLATION; PORCINE INTESTINE; SOURCE MATERIAL; STRUCTURAL COMPOSITION;

ACETYLATION; ANIMALS; DRUG PRODUCTS; MOLECULAR WEIGHT; QUALITY CONTROL; VIRUSES;

POLYSACCHARIDES;

GLYCOSAMINOGLYCAN POLYSULFATE; HEPARIN; IDURONIC ACID;

BIOENGINEERING; COAGULATION; DRUG; ENZYME ACTIVITY; MUCUS; ORGANIC COMPOUND; PIG; PRION DISEASE; QUALITY CONTROL; VIRUS;

ANTICOAGULATION; ARTICLE; BACTERIAL STRAIN; BIOENGINEERING; CONTROLLED STUDY; DEACETYLATION; ENZYME MODIFICATION; EPIMERIZATION; INTESTINE MUCOSA; MOLECULAR WEIGHT; NONHUMAN; SULFONATION;

ACETYLGLUCOSAMINE; ANTICOAGULANTS; DISACCHARIDES; ESCHERICHIA COLI; HEPARIN; HUMANS; INDUSTRIAL MICROBIOLOGY; MOLECULAR STRUCTURE; MOLECULAR WEIGHT;

ANIMALIA; SUS;

EID: 79959248741     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3231-5     Document Type: Article

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