Exercise training improves in vivo endothelial repair capacity of early endothelial progenitor cells in subjects with metabolic syndrome

European Journal of Cardiovascular Prevention and Rehabilitation

Volumn 18, Issue 3, 2011, Pages 406-414

  Sonnenschein, Kristina ^a   Horváth, Tibor ^a   Mueller, Maja ^a,b   Markowski, Andrea ^a   Siegmund, Tina ^a   Jacob, Christian ^a   Drexler, Helmut ^a   Landmesser, Ulf ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Endothelial function; Endothelial progenitor cells; Exercise training; Metabolic syndrome; Nitric oxide; Oxidative stress

Indexed keywords

NITRIC OXIDE; SUPEROXIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY BLOOD FLOW; ARTICLE; BICYCLE ERGOMETRY; CELL REGENERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; ECHOGRAPHY; ELECTRON SPIN RESONANCE; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM INJURY; EXERCISE; FEMALE; HUMAN; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ANIMALS; CELLS, CULTURED; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOTHELIUM, VASCULAR; EXERCISE; EXERCISE TEST; EXERCISE THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; METABOLIC SYNDROME X; MICE; MICE, NUDE; MIDDLE AGED; NITRIC OXIDE; RECOVERY OF FUNCTION; STEM CELLS; SUPEROXIDES; VASODILATION;

EID: 79959216516     PISSN: 17418267     EISSN: 17418275     Source Type: Journal    
DOI: 10.1177/1741826710389373     Document Type: Article

References (47)

1. Halcox JP, Donald AE, Ellins E, Witte DR, Shipley MJ, Brunner EJ, et al. Endothelial function predicts progression of carotid intima-media thickness. Circulation 2009; 119: 1005-1012.
2. Landmesser U, Hornig B and Drexler H. Endothelial function: a critical determinant in atherosclerosis? Circulation 2004; 109(Suppl 1): II27-II33.
3. Lusis AJ. Atherosclerosis. Nature 2000; 407: 233-241.
4. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003; 348: 593-600. (Pubitemid 36204953)
5. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005; 353: 999-1007. (Pubitemid 41262334)
6. Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005; 111: 2981-2987. (Pubitemid 40814192)
7. Sorrentino SA, Bahlmann FH, Besler C, Muller M, Schulz S, Kirchhoff N, et al. Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Circulation 2007; 116: 163-173. (Pubitemid 47057522)
8. Kalka C, Masuda H, Takahashi T, Kalka-Moll WM, Silver M, Kearney M, et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci USA 2000; 97: 3422-3427. (Pubitemid 30183318)
9. Werner N, Junk S, Laufs U, Link A, Walenta K, Bohm M, et al. Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury. Circ Res 2003; 93: e17-e24.
10. Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, et al. Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation 2003; 108: 3115-3121. (Pubitemid 38031801)
11. Giannotti G, Doerries C, Mocharla P, Mueller M, Horvàth T, Jiang H, et al. Impaired in vivo endothelial repair capacity of endothelial progenitor cells in prehypertension - relation to endothelial dysfunction and senescence. Hypertension 2010; 55(6): 1389-1397.
12. Schroeter MR, Leifheit M, Sudholt P, Heida NM, Dellas C, Rohm I, et al. Leptin enhances the recruitment of endothelial progenitor cells into neointimal lesions after vascular injury by promoting integrin-mediated adhesion. Circ Res 2008; 103: 536-544.
13. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 2002; 106: 2781-2786. (Pubitemid 35396976)
14. Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder JD, et al. Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes 2007; 56: 666-674. (Pubitemid 46348461)
15. Sorrentino S, Besler C, Rohrer L, Meyer M, Heinrich K, Bahlmann F, et al. Endothelial-vasoprotective effects of HDL are impaired in patients with type-2 diabetes, but are improved after extended-release niacin therapy. Circulation 2010; 121(1): 110-122.
16. Leon AS, Connett J, Jacobs Jr DR and Rauramaa R. Leisure-time physical activity levels and risk of coronary heart disease and death. The Multiple Risk Factor Intervention Trial. JAMA 1987; 258: 2388-2395.
17. Manson JE, Greenland P, LaCroix AZ, Stefanick ML, Mouton CP, Oberman A, et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 2002; 347: 716-725. (Pubitemid 35203902)
18. Paffenbarger Jr RS, Hyde RT, Wing AL, Lee IM, Jung DL and Kampert JB. The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 1993; 328: 538-545. (Pubitemid 23053830)
19. Blair SN, Kohl 3rd HW, Paffenbarger Jr RS, Clark DG, Cooper KH and Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989; 262: 2395-2401.
20. Hakim AA, Petrovitch H, Burchfiel CM, Ross GW, Rodriguez BL, White LR, et al. Effects of walking on mortality among nonsmoking retired men. N Engl J Med 1998; 338: 94-99. (Pubitemid 28042272)
21. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342: 454-460. (Pubitemid 30100232)
22. Hornig B, Maier V and Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation 1996; 93: 210-214. (Pubitemid 26031476)
23. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jurgens K, et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 2004; 109: 220-226. (Pubitemid 38114143)
24. Adams V, Lenk K, Linke A, Lenz D, Erbs S, Sandri M, et al. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler Thromb Vasc Biol 2004; 24: 684-690. (Pubitemid 38451604)
25. Sandri M, Adams V, Gielen S, Linke A, Lenk K, Krankel N, et al. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation 2005; 111: 3391-3399. (Pubitemid 40923392)
26. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/ National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-2752. (Pubitemid 41532612)
27. Zimmet P, Magliano D, Matsuzawa Y, Alberti G and Shaw J. The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb 2005; 12: 295-300.
28. Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009; 119: 628-647.
29. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997; 275: 964-967. (Pubitemid 27087709)
30. Bahlmann FH, De Groot K, Spandau JM, Landry AL, Hertel B, Duckert T, et al. Erythropoietin regulates endothelial progenitor cells. Blood 2004; 103: 921-926. (Pubitemid 38129551)
31. Landmesser U, Engberding N, Bahlmann FH, Schaefer A, Wiencke A, Heineke A, et al. Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation 2004; 110: 1933-1939. (Pubitemid 39331904)
32. Sorrentino SA, Besler C, Rohrer L, Meyer M, Heinrich K, Bahlmann FH, et al. Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy. Circulation 2010; 121: 110-122.
33. Landmesser U, Cai H, Dikalov S, McCann L, Hwang J, Jo H, et al. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 2002; 40: 511-515.
34. Spiekermann S, Landmesser U, Dikalov S, Bredt M, Gamez G, Tatge H, et al. Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation 2003; 107: 1383-1389. (Pubitemid 36350736)
35. Kleschyov AL, Mollnau H, Oelze M, Meinertz T, Huang Y, Harrison DG, et al. Spin trapping of vascular nitric oxide using colloid Fe(II)- diethyldithiocarbamate. Biochem Biophys Res Commun 2000; 275: 672-677.
36. Brouchet L, Krust A, Dupont S, Chambon P, Bayard F and Arnal JF. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation 2001; 103: 423-428. (Pubitemid 32105983)
37. Carmeliet P, Moons L, Stassen JM, De Mol M, Bouche A, van den Oord JJ, et al. Vascular wound healing and neointima formation induced by perivascular electric injury in mice. Am J Pathol 1997; 150: 761-776. (Pubitemid 27073802)
38. Lindner V, Fingerle J and Reidy MA. Mouse model of arterial injury. Circ Res 1993; 73: 792-796. (Pubitemid 23306123)
39. Landmesser U, Spiekermann S, Dikalov S, Tatge H, Wilke R, Kohler C, et al. Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase. Circulation 2002; 106: 3073-3078. (Pubitemid 35440291)
40. Landmesser U, Bahlmann F, Mueller M, Spiekermann S, Kirchhoff N, Schulz S, et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 2005; 111: 2356-23563.
41. Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370-1376. (Pubitemid 37466185)
42. Walter DH, Rittig K, Bahlmann FH, Kirchmair R, Silver M, Murayama T, et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 2002; 105: 3017-3024. (Pubitemid 34693836)
43. Hagensen MK, Shim J, Thim T, Falk E and Bentzon JF. Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis. Circulation 2010; 121: 898-905.
44. Laufs U, Urhausen A, Werner N, Scharhag J, Heitz A, Kissner G, et al. Running exercise of different duration and intensity: effect on endothelial progenitor cells in healthy subjects. Eur J Cardiovasc Prev Rehabil 2005; 12: 407-414. (Pubitemid 41192175)
45. Case J, Ingram DA and Haneline LS. Oxidative stress impairs endothelial progenitor cell function. Antioxid Redox Signal 2008; 10: 1895-1907.
46. Adams V, Linke A, Krankel N, Erbs S, Gielen S, Mobius-Winkler S, et al. Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation 2005; 111: 555-562. (Pubitemid 40216482)
47. Ii M, Takeshita K, Ibusuki K, Luedemann C, Wecker A, Eaton E, et al. Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice. Circulation 2010; 121: 1104-1112.