메뉴 건너뛰기




Volumn 60, Issue 2, 2011, Pages 253-261

The role of non-aromatizable testosterone metabolite in metabolic pathways

Author keywords

Adipose tissue; Atherosclerosis; Metabolic syndrome; Non aromatizable androgen; Testosterone

Indexed keywords


EID: 79959202924     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: 10.33549/physiolres.932080     Document Type: Review
Times cited : (24)

References (63)
  • 2
    • 43049114158 scopus 로고    scopus 로고
    • The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men
    • AMORY JK, ANAWALT BD, MATSUMOTO AM, PAGE ST, BREMNER WJ, WANG C, SWERDLOFF RS, CLARK RV: The effect of 5alpha-reductase inhibition with dutasteride and finasteride on bone mineral density, serum lipoproteins, hemoglobin, prostate specific antigen and sexual function in healthy young men. J Urol 179: 2333-2338, 2008.
    • (2008) J Urol , vol.179 , pp. 2333-2338
    • Amory, J.K.1    Anawalt, B.D.2    Matsumoto, A.M.3    Page, S.T.4    Bremner, W.J.5    Wang, C.6    Swerdloff, R.S.7    Clark, R.V.8
  • 3
    • 0031018808 scopus 로고    scopus 로고
    • Immunocytochemical evidence for differential subcellular localization of 5 alpha-reductase isoenzymes in human tissues
    • AUMUELLER G, EICHELER W, RENNEBERG H, ADERMANN K, VILJA P, FORSSMANN WG: Immunocytochemical evidence for differential subcellular localization of 5 alpha-reductase isoenzymes in human tissues. Acta Anat 156: 241-252, 1996.
    • (1996) Acta Anat , vol.156 , pp. 241-252
    • Aumueller, G.1    Eicheler, W.2    Renneberg, H.3    Adermann, K.4    Vilja, P.5    Forssmann, W.G.6
  • 8
    • 34250623941 scopus 로고    scopus 로고
    • Transcriptoric characterization of long term dihydrotestosterone effects in adipose tissue
    • BOLDUC C, YOSHIOKA M, ST-AMAND J: Transcriptoric characterization of long term dihydrotestosterone effects in adipose tissue. Obesity 15: 1107-1132, 2007.
    • (2007) Obesity , vol.15 , pp. 1107-1132
    • Bolduc, C.1    Yoshioka, M.2    St-Amand, J.3
  • 9
    • 62349139045 scopus 로고    scopus 로고
    • The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men
    • BRAMBILLA DJ, MATSUMOTO AM, ARAUJO AB, MCKINLAY JB: The effect of diurnal variation on clinical measurement of serum testosterone and other sex hormone levels in men. J Clin Endocrinol Metab 94: 907-913, 2009.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 907-913
    • Brambilla, D.J.1    Matsumoto, A.M.2    Araujo, A.B.3    Mckinlay, J.B.4
  • 10
    • 0014429464 scopus 로고
    • The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro
    • BRUCHOVSKY N, WILSON JD: The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 243: 2012-2021, 1968.
    • (1968) J Biol Chem , vol.243 , pp. 2012-2021
    • Bruchovsky, N.1    Wilson, J.D.2
  • 11
    • 11244269805 scopus 로고    scopus 로고
    • Patients with a large prostate show a higher prevalence of androgenetic alopecia
    • CHEN W, YANG CC, CHEN GY, WU MC, SHEU HM, TZAI TS: Patients with a large prostate show a higher prevalence of androgenetic alopecia. Arch Dermatol Res 296: 245-249, 2004.
    • (2004) Arch Dermatol Res , vol.296 , pp. 245-249
    • Chen, W.1    Yang, C.C.2    Chen, G.Y.3    Wu, M.C.4    Sheu, H.M.5    Tzai, T.S.6
  • 15
    • 79959243161 scopus 로고
    • Urinary excretion of androgenic substances after intramuscular and oral administration of testosterone propionate to humans
    • DORFMAN RI, HAMILTON JB: Urinary excretion of androgenic substances after intramuscular and oral administration of testosterone propionate to humans. J Clin Invest 18: 67-71, 1939.
    • (1939) J Clin Invest , vol.18 , pp. 67-71
    • Dorfman, R.I.1    Hamilton, J.B.2
  • 17
    • 77955910645 scopus 로고    scopus 로고
    • Changes of metabolic profile in men treated for androgenetic alopecia with 1 mg finasteride
    • DUŠKOVÁ M, HILL M, STÁRKA L: Changes of metabolic profile in men treated for androgenetic alopecia with 1 mg finasteride. Endocr Regul 44: 3-8, 2010.
    • (2010) Endocr Regul , vol.44 , pp. 3-8
    • Dušková, M.1    Hill, M.2    Stárka, L.3
  • 19
    • 0036159759 scopus 로고    scopus 로고
    • Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia
    • FINASTERIDE MALE PATTERN HAIR LOSS STUDY GROUP
    • FINASTERIDE MALE PATTERN HAIR LOSS STUDY GROUP: Long-term (5-year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia. Eur J Dermatol 12: 38-49, 2002.
    • (2002) Eur J Dermatol , vol.12 , pp. 38-49
  • 20
    • 0029871095 scopus 로고    scopus 로고
    • Baldness and ischemic heart disease in a national sample of men
    • FORD ES, FREEDMAN DS, BYERS T: Baldness and ischemic heart disease in a national sample of men. Amer J Epidemiol 143: 651-657, 1996.
    • (1996) Amer J Epidemiol , vol.143 , pp. 651-657
    • Ford, E.S.1    Freedman, D.S.2    Byers, T.3
  • 25
    • 0025884064 scopus 로고
    • Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study
    • GRAY A, FELDMAN HA, MCKINLAY JB, LONGCOPE C: Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 73: 1016-1025, 1991.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1016-1025
    • Gray, A.1    Feldman, H.A.2    Mckinlay, J.B.3    Longcope, C.4
  • 27
    • 0034065417 scopus 로고    scopus 로고
    • Male pattern baldness and clinical prostate cancer in the epidemiologic follow-up of the first National Health and Nutrition Examination survey
    • HAWK W, BRESLOW RA, GRAUBARD BI: Male pattern baldness and clinical prostate cancer in the epidemiologic follow-up of the first National Health and Nutrition Examination survey. Cancer Epidemiol Biomerkers Prev 9: 523-527, 2000.
    • (2000) Cancer Epidemiol Biomerkers Prev , vol.9 , pp. 523-527
    • Hawk, W.1    Breslow, R.A.2    Graubard, B.I.3
  • 33
    • 0016359646 scopus 로고
    • Steroid 5α-reductase deficiency in man: an inherited form of male pseudohermaphroditism
    • IMPERATO-MCGINLEY J, GUERRERO L, GAUTIER T, PETERSON RE: Steroid 5α-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science 186: 1213-1215, 1974.
    • (1974) Science , vol.186 , pp. 1213-1215
    • Imperato-Mcginley, J.1    Guerrero, L.2    Gautier, T.3    Peterson, R.E.4
  • 34
    • 0037203503 scopus 로고    scopus 로고
    • Androgens and alopecia
    • KAUFMAN KD: Androgens and alopecia. Mol Cell Endocrinol 198: 89-95, 2002.
    • (2002) Mol Cell Endocrinol , vol.198 , pp. 89-95
    • Kaufman, K.D.1
  • 35
    • 0027510479 scopus 로고
    • A case-control study of baldness in relation to myocardial infarction in men
    • LESKO SM, ROSENBERG L, SHAPIRO S: A case-control study of baldness in relation to myocardial infarction in men. J Amer Med Assoc 269: 998-1003, 1993.
    • (1993) J Amer Med Assoc , vol.269 , pp. 998-1003
    • Lesko, S.M.1    Rosenberg, L.2    Shapiro, S.3
  • 36
    • 34548648537 scopus 로고    scopus 로고
    • Experimental arterial thrombosis regulated by androgen and its receptor via modulation of platelet activation
    • LI S, LI X, LI J, DENG X, LI Y, CONG Y: Experimental arterial thrombosis regulated by androgen and its receptor via modulation of platelet activation. Thromb Res 121: 127-134, 2007.
    • (2007) Thromb Res , vol.121 , pp. 127-134
    • Li, S.1    Li, X.2    Li, J.3    Deng, X.4    Li, Y.5    Cong, Y.6
  • 39
    • 0035737377 scopus 로고    scopus 로고
    • Hormone profile in the aging male
    • MAIER U: Hormone profile in the aging male. Sien Med Wochenschr 151: 422-425, 2001.
    • (2001) Sien Med Wochenschr , vol.151 , pp. 422-425
    • Maier, U.1
  • 40
    • 0034734672 scopus 로고    scopus 로고
    • Early anderogenetic alopecia as a marker of insulin resistance
    • MATILAINEN V, KOSKELA P, KEINANEN-KIUKAANNIEMI S: Early anderogenetic alopecia as a marker of insulin resistance. Lancet 356: 1165-1166, 2000.
    • (2000) Lancet , vol.356 , pp. 1165-1166
    • Matilainen, V.1    Koskela, P.2    Keinanen-Kiukaanniemi, S.3
  • 42
    • 0141838958 scopus 로고    scopus 로고
    • Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis
    • NG MK, QUINN CM, MCCROHON JA, NAKHLA S, JESSUP W, HANDELSMAN DJ, CELERMAJER DS, DEATH AK: Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis. J Am Coll Cardiol 42: 1306-1313, 2003.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1306-1313
    • Ng, M.K.1    Quinn, C.M.2    Mccrohon, J.A.3    Nakhla, S.4    Jessup, W.5    Handelsman, D.J.6    Celermajer, D.S.7    Death, A.K.8
  • 43
    • 34447131545 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men
    • NIELSEN TL, HAGEN C, WRAAE K, BRIXEN K, PETERSEN PH, HAUG E, LARSEN R, ANDERSEN M: Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men. J Clin Endocrinol Metab 92: 2696-2705, 2007.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2696-2705
    • Nielsen, T.L.1    Hagen, C.2    Wraae, K.3    Brixen, K.4    Petersen, P.H.5    Haug, E.6    Larsen, R.7    Andersen, M.8
  • 45
    • 0026715201 scopus 로고
    • The hypothalamo-pituitary regulation of androgen secretion in young men after prolonged physical stress combined with energy and sleep deprivation
    • OPSTAD PK: The hypothalamo-pituitary regulation of androgen secretion in young men after prolonged physical stress combined with energy and sleep deprivation. Acta Endocrinol (Copenh) 127: 231-236, 1992.
    • (1992) Acta Endocrinol (Copenh) , vol.127 , pp. 231-236
    • Opstad, P.K.1
  • 47
    • 0016553292 scopus 로고
    • Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol
    • PIRKE KM, DOERR P: Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Acta Endocrinol (Copenh) 80: 171-178, 1975.
    • (1975) Acta Endocrinol (Copenh) , vol.80 , pp. 171-178
    • Pirke, K.M.1    Doerr, P.2
  • 48
    • 33751185139 scopus 로고    scopus 로고
    • Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats
    • POTTER LK, ZAGER MG, BARTON HA: Mathematical model for the androgenic regulation of the prostate in intact and castrated adult male rats. Am J Physiol Endocrinol Metab 291: 952-964, 2006.
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. 952-964
    • Potter, L.K.1    Zager, M.G.2    Barton, H.A.3
  • 53
    • 41149096489 scopus 로고    scopus 로고
    • Baldness and myocardial infarction in men: the atherosclerosis risk in communities study
    • SHAHAR E, HEISS G, ROSAMOND WD, SZKLO M: Baldness and myocardial infarction in men: the atherosclerosis risk in communities study. Am J Epidemiol 167: 676-683, 2008.
    • (2008) Am J Epidemiol , vol.167 , pp. 676-683
    • Shahar, E.1    Heiss, G.2    Rosamond, W.D.3    Szklo, M.4
  • 55
    • 0242468434 scopus 로고    scopus 로고
    • Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptormediated pathway
    • SINGH R, ARTAZA JN, TAYLOR WE, GONZALEZ-CADAVID NF, BHASIN S: Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptormediated pathway. Endocrinology 144: 5081-5088, 2003.
    • (2003) Endocrinology , vol.144 , pp. 5081-5088
    • Singh, R.1    Artaza, J.N.2    Taylor, W.E.3    Gonzalez-Cadavid, N.F.4    Bhasin, S.5
  • 56
    • 61349110666 scopus 로고    scopus 로고
    • Dihydrotestosterone and estradiol-17beta mutually neutralize their inhibitory effects on human vascular smooth muscle cell growth in vitro
    • SOMJEN D, KOHEN F, GAYER B, KNOLL E, MANY A, STERN N: Dihydrotestosterone and estradiol-17beta mutually neutralize their inhibitory effects on human vascular smooth muscle cell growth in vitro. J Steroid Biochem Mol Biol 113: 171-176, 2009.
    • (2009) J Steroid Biochem Mol Biol , vol.113 , pp. 171-176
    • Somjen, D.1    Kohen, F.2    Gayer, B.3    Knoll, E.4    Many, A.5    Stern, N.6
  • 57
    • 67449103058 scopus 로고    scopus 로고
    • Free testosterone and free dihydrotestosterone throughout the life span of men
    • STÁRKA L, POSPÍSILOVÁ H, HILL M: Free testosterone and free dihydrotestosterone throughout the life span of men. J Steroid Biochem Mol Biol 116: 118-120, 2009.
    • (2009) J Steroid Biochem Mol Biol , vol.116 , pp. 118-120
    • Stárka, L.1    Pospísilová, H.2    Hill, M.3
  • 58
    • 43349097124 scopus 로고    scopus 로고
    • Dihydrotestosterone and testosterone throughout the life span of Czech men
    • STÁRKA L, DUSKOVÁ M, HILL M: Dihydrotestosterone and testosterone throughout the life span of Czech men. Neuro Endocrinol Lett 29: 201-204, 2008.
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 201-204
    • Stárka, L.1    Dusková, M.2    Hill, M.3
  • 60
    • 36949000088 scopus 로고    scopus 로고
    • Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    • UEMURA M, TAMURA K, CHUNG S, HONMA S, OKUYAMA A, NAKAMURA Y, NAKAGAWA H: Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 99: 81-86, 2008.
    • (2008) Cancer Sci , vol.99 , pp. 81-86
    • Uemura, M.1    Tamura, K.2    Chung, S.3    Honma, S.4    Okuyama, A.5    Nakamura, Y.6    Nakagawa, H.7
  • 62
    • 70349683029 scopus 로고    scopus 로고
    • Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players
    • VAN DER MERWE J, BROOKS NE, MYBURGH KH: Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players. Clin J Sport Med 19: 399-404, 2009.
    • (2009) Clin J Sport Med , vol.19 , pp. 399-404
    • Van Der Merwe, J.1    Brooks, N.E.2    Myburgh, K.H.3
  • 63
    • 62949105195 scopus 로고    scopus 로고
    • Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells
    • YANES LL, ROMERO DG: Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells. Mol Cell Endocrinol 303: 50-56, 2009.
    • (2009) Mol Cell Endocrinol , vol.303 , pp. 50-56
    • Yanes, L.L.1    Romero, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.