Body composition and metabolic profile in women with complete androgen insensitivity syndrome

Sexual Development

Volumn 3, Issue 4, 2009, Pages 188-193

  Dati, E ^a   Baroncelli, G I ^a   Mora, S ^e   Russo, G ^e   Baldinotti, F ^b   Parrini, D ^c   Erba, P ^d   Simi, P ^b   Bertelloni, S ^a,f  

^a II Pediatric Division   (Italy)

^b Cytogenetic and Molecular Biology Division

^c University Hospital   (United Kingdom)

^d UNIVERSITY HOSPITAL OF PISA   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f UNIVERSITY OF PISA   (Italy)

Author keywords

Androgen insensitivity syndrome; Body composition; Body fat; Body mass index; Insulin sensitivity; Metabolic syndrome; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; GLUCOSE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN;

ADULT; AGING; ANDROGEN INSENSITIVITY SYNDROME; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; ITALY; KARYOTYPE 46,XX; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; METABOLIC PARAMETERS; MIDDLE AGED; OBESITY; PREVALENCE; PRIORITY JOURNAL;

ABSORPTIOMETRY, PHOTON; ADULT; ANDROGEN-INSENSITIVITY SYNDROME; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; FAMILY; FEMALE; HUMANS; INSULIN RESISTANCE; LIFE STYLE; MALE; METABOLOME; MIDDLE AGED; YOUNG ADULT;

EID: 70349296887     PISSN: 16615425     EISSN: 16615433     Source Type: Journal    
DOI: 10.1159/000228719     Document Type: Article

References (18)

1. Bertelloni S, Dati E, Hiort O: Diagnosis of 17-hydroxysteroid dehydrogenase deficiency: a review. Expert Rev Endocrinol Metab 4: 53-65 (2009).
2. Brown M: Skeletal muscle and bone: effect of sex steroids and aging. Adv Physiol Educ 32: 120-126(2008).
3. Cacciari E, Milani S, Balsamo A, Dammacco F, De Luca F, et al: Italian cross-sectional growth charts for height, weight and BMI (6-20 y). Eur J Clin Nutr 56: 171-180 (2002).
4. Cacciari E, Milani S, Balsamo A, Spada E, Bona G, et al: Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J En-docrinol Invest 29: 581-593(2006).
5. Chiocca E, Dati E, Baroncelli GI, Mora S, Par-rini D, et al: Body mass index and body composition in adolescents treated by gonadotropin releasing hormone analogue triptorelin depot for central precocious puberty: data at near final height. Neuroendo-crinology 89:441-447 (2009).
6. Day C: Metabolic syndrome, or What you will: definitions and epidemiology. Diab Vasc Dis Res 4: 32-38 (2007).
7. Fan W, Yanase T, Nomura M, Okabe T, Goto K, et al: Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion. Diabetes 54: 1000-1008 (2005).
8. Geloneze B, Repetto EM, Geloneze SR, Tambas-cia MA, Ermetice MN. The threshold value for insulin resistance (HOMA-IR) in an ad-mixtured population IR in the Brazilian Metabolic Syndrome Study. Diabetes Res Clin Pract 2: 219-220(2006).
9. Hughes IA: Disorders of sex development: a new definition and classification. Best Pract Res Clin Endocrinol Metab 22: 119-134 (2008).
10. ISTAT: Condizioni di salute, fattori di rischio e ricorso ai servizi sanitari [Health status, risk factors and health service utilization in Italy]. www.istat.it/salastampa/comunicati/non-calendario/20070302-00/testointe-grale. pdf (accessed December 3, 2008).
11. Lin HY, Xu Q, Yeh S, Wang RS, Sparks JD, Chang C: Insulin and leptin resistance with hyper-leptinemia in mice lacking androgen receptor. Diabetes 54: 1717-1725 (2005).
12. Stanworth RD, Jones TH: Testosterone in obesity, metabolic syndrome and type 2 diabetes. Front Horm Res 37: 74-90(2009).
13. Tanner JM: Foetus into Man: Physical Growth from Conception to Maturity (Open Books, London 1978).
14. Warne GL: Long-term outcome of disorders of sex development. Sex Dev 2: 268-277 (2008).
15. Wells JC: Sexual dimorphism of body composition. Best Pract Res Clin Endocrinol Metab 21:415-430 (2007).
16. WHO: Obesity. Preventing and managing the global epidemic. Report of a WHO consultation on obesity. WHO/NUT/NCD/981, Geneva, 1998.
17. Yanase T, Fan W, Kyoya K, Min L, Takayanagi R, Kato S, Nawata H: Androgens and metabolic syndrome: lessons from androgen receptor knock out (ARKO) mice. J Steroid Biochem Mol Biol 109:254-257 (2008).
18. Yu IC, Lin HY, Liu NC, Wang RS, Sparks JD, Yeh S, Chang C: Hyperleptinemia without obesity in male mice lacking androgen receptor in adipose tissue. Endocrinology 149: 2361-2368 (2008).