Moderate prevalence of transmitted drug resistance and high HIV-1 genetic diversity in patients from Mato Grosso State, Central Western Brazil

Journal of Medical Virology

Volumn 83, Issue 8, 2011, Pages 1301-1307

  Ferreira, Adriana Santarém ^a   Cardoso, Ludimila Paula Vaz ^b   Stefani, Mariane Martins de Araújo ^b  

^a LACEN Public Health Central Laboratory   (Brazil)

^b FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

Author keywords

Brazil; HIV 1; Subtypes; Transmitted drug resistance

Indexed keywords

ABACAVIR; ATAZANAVIR; DELAVIRDINE; DIDANOSINE; EFAVIRENZ; FOSAMPRENAVIR; INDINAVIR; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE; TENOFOVIR; ZIDOVUDINE;

ARTICLE; BOLIVIA; BRAZIL; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHYLOGENY; POLYMERASE CHAIN REACTION; PREVALENCE; VIRUS MUTATION; VIRUS RECOMBINANT;

ADOLESCENT; ADULT; AGED; ANTI-HIV AGENTS; BRAZIL; CHILD; DRUG RESISTANCE, VIRAL; FEMALE; GENETIC VARIATION; GENOTYPE; HIV INFECTIONS; HIV PROTEASE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREGNANCY; PREVALENCE; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79959201984     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.22128     Document Type: Article

References (35)

1. Bangsberg DR, Perry S, Charlebois ED, Clark RA, Roberston M, Zolopa AR, Moss A. 2001. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS 15: 1181-1183.
2. Barbour JD, Hecht FM, Wrin T, Liegler TJ, Ramstead CA, Busch MP, Segal MR, Petropoulos CJ, Grant RM. 2004. Persistence of primary drug resistance among recently HIV-1 infected adults. AIDS 18: 1683-1689.
3. Bello G, Guimarães ML, Chequer-Fernandez SL, Eyer-Silva WA, Couto-Fernandez JC, Teixeira SL, Morgado MG. 2007. Increasing genetic distance to HIV-1 subtype B and F1 consensus sequences in the Brazilian epidemic: A challenge for vaccine strategies based on central immunogens? Infect Genet Evol 5: 594-599.
4. Brazil. 2010. Epidemiological Bulletin of the Brazilian STD/AIDS Program. Ministry of Health, Brazil. Brasília, VII n° 01.
5. Brazilian STD/AIDS Program. Ministry of Health, Brazil. Accessed March 2011.
6. Brígido LF, Franco HM, Custódio RM, Oliveira CA, P Ferreira JL, Eira M, Bergel F, Araújo F, Carvalheiro JR, Rodrigues R. 2005. Molecular characteristics of HIV type 1 circulating in Sao Paulo, Brazil. AIDS Res Hum Retroviruses 21: 673-682.
7. Brindeiro RM, Diaz RS, Sabino EC, Morgado MG, Pires IL, Brigido L, Dantas MC, Barreira D, Teixeira PR, Tanuri A, Brazilian Network for Drug Resistance Surveillance. 2003. Brazilian Network for HIV Drug Resistance Surveillance (HIV-BResNet): A survey of chronically infected individuals. AIDS 17: 1063-1069.
8. Cardoso LPV, Queiroz BB, Stefani MMA. 2009. HIV-1 pol phylogenetic diversity and antiretroviral resistance mutations in treatment naïve patients from Central West Brazil. J Clin Virol 46: 134-139.
9. Cardoso LPV, Pereira GA, Viegas AA, Schmaltz LE, Stefani MM. 2010. HIV-1 primary and secondary antiretroviral drug resistance and genetic diversity among pregnant women from central Brazil. J Med Virol 82: 351-357.
10. Carvalho BC, Cardoso LV, Damasceno S, Stefani MM. 2011. Moderate Prevalence of Transmitted Drug Resistance and Interiorization of HIV-1 Subtype C in The Inland North State of Tocantins, Brazil. AIDS Res Hum Retroviruses Epub ahead of print (doi:10.1089/aid.2010.0334).
11. Couto-Fernandez JC, Eyer-Silva WA, Guimarães ML, Chequer-Fernandez SL, Grinsztejn B, Delaporte E, Peeters M, Morgado MG. 2006. Phylogenetic analysis of Brazilian HIV type 1 subtype D strains: Tracing the origin of this subtype in Brazil. AIDS Res Hum Retroviruses 22: 207-211.
12. Eyer-Silva WA, Couto-Fernandez JC, Silva-de-Jesus C, Morgado MG., 2008. Prevalence of HIV type 1 drug resistance mutations in treatment-naïve and experienced patients from resource-limited settings with universal access to antiretroviral therapy: A survey in two small Brazilian cities. Mem Inst Oswaldo Cruz 103: 143-149.
13. Frenkel LM, Wagner LE, Atwood SM, Cummins TJ, Dewhurst S. 1995. Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine. J Clin Microbiol 33: 342-347.
14. Galvão J. 2002. Access to antiretroviral drugs in Brazil. Lancet 360: 1862-1865.
15. Gifford RJ, Liu TF, Rhee SY, Kiuchi M, Hue S, Pillay D, Shafer RW. 2009. The calibrated population resistance tool: Standardized genotypic estimation of transmitted HIV-1 drug resistance. Bioinformatics 20: 1-3.
16. Guimarães ML, Eyer-Silva WA, Couto-Fernandez JC, Morgado MG., 2008. Identification of two new CRF-BF in Rio de Janeiro State, Brazil. AIDS 22: 433-438.
17. Hall TA. 1999. BioEdit: A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/MT. Nucleic Acids Symp Ser 41: 95-98.
18. Inocêncio LA, Pereira AA, Sucupira MCA, Couto-Fernandez JC, Jorge CP, Souza DFC, Fink HT, Diaz RS, Becker IM, Suffert TA, Arruda MB, Macedo O, Simão MBG, Tanuri A. 2009. Brazilian Network for HIV Drug Resistance Surveillance: A survey of individuals recently diagnosed with HIV. J Int AIDS Soc 12: 1-6.
19. Johnson JA, Li JF, Wei X, Lipscomb J, Irlbeck D, Craig C, Smith A, Bennett DE, Monsour M, Sandstrom P, Lanier ER, Heneine W. 2008. Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy. PLoS Med 5: 1112-1122.
20. Johnson VA, Brun-Vezinet F, Clotet B, Gunthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman DD. 2009. Update of the drug resistance mutations in HIV-1: December 2009. Top HIV Med 17: 138-145.
21. Kimura M. 1980. A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol 16: 111-120.
22. Kozal MJ, Shah N, Shen N, Yang R, Fucini R, Merigan TC, Richman DD, Morris D, Hubbell E, Chee M, Gingeras TR. 1996. Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat Med 2: 753-759.
23. Lole KS, Bollinger RC, Paranjape RS, Gadkari D, Kulkarni SS, Novak NG. 1999. Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol 73: 152-160.
24. Medeiros LB, Lacerda HR, Cavalcanti AMS, Albuquerque MFPM. 2006. Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil. Mem Inst Oswaldo Cruz 101: 845-849.
25. Oliveira T, Deforche K, Cassol S, Salminen M, Paraskevis D, Seebregts C, Snoeck J, van Rensburg EJ, Wensing AM, van de Vijver DA, Boucher CA, Camacho R, Vandamme AM. 2005. An automated genotyping system for analysis of HIV-1 and other microbial sequences. Bioinformatics 21: 3797-3800.
26. Ramos A, Tanuri A, Schechter M, Rayfield MA, Hu DJ, Cabral MC, Bandea CI, Baggs J, Pieniazek D. 1999. Dual and recombinant infections: An integral part of the HIV-1 epidemic in Brazil. Emerg Infect Dis 5: 65-74.
27. Rodrigues R, Scherer LC, Oliveira CM, Franco HM, Sperhacke RD, Ferreira JL, Castro SM, Stella IM, Brigido LF. 2006. Low prevalence of primary antiretroviral resistance mutations and predominance of HIV-1 clade C at polymerase gene in newly diagnosed individuals from south Brazil. Virus Res 116: 201-207.
28. Sá-Filho DJ, Sanabani S, Diaz RS, Munerato P, Brunstein A, Fusuma E, Sabino EC, Janini LM. 2005. Analysis of full-length human immunodeficiency virus type 1 genome reveals a variable spectrum of subtypes B and f recombinants in São Paulo, Brazil. AIDS Res Hum Retroviruses 21: 145-151.
29. Sá-Filho DJ, Sucupira MC, Caseiro MM, Sabino EC, Diaz RS, Janini LM. 2006. Identification of two HIV type 1 circulating recombinant forms in Brazil. AIDS Res Hum Retroviruses 22: 1-13.
30. Santos AF, Schrago CG, Martinez AM, Mendoza-Sassi R, Silveira J, Sousa TM, Lengruber RB, Soares EA, Sprinz E, Soares MA. 2007. Epidemiologic and evolutionary trends of HIV-1 CRF31-BC-related strains in southern Brazil. J Acquir Immune Defic Syndr 45: 328-333.
31. Shafer RW, Winters MA, Palmer S, Merigan TC. 1998. Multiple concurrent reverse transcriptase and protease mutations multidrug resistance of HIV-1 isolates from heavily treated patients. Ann Intern Med 128: 906-911.
32. Sprinz E, Netto EM, Lima MPJS, Furtado JJD, Eira M, Zajdenverg R, Madruga JV, Lewi DS, Pedro RJ, Soares MA. 2009. Primary antiretroviral drug resistance among HIV type infected individuals in Brazil. AIDS Res Hum Retroviruses 25: 861-867.
33. Stefani MM, Pereira GA, Martelli CM, Shindo N, Galvao-Castro B. 2000. Evidence of HIV-1 genetic diversity among pregnant women with AIDS or infected with HIV-1 in Central Brazil. J Acquir Immune Defic Syndr 2: 205-207.
34. Stefani MM, Pereira GA, Lins JA, Alcantara KC, Silveira AA, Viegas AA, Maya NC, Mussi AH. 2007. Molecular screening shows extensive HIV-1 genetic diversity in Central West Brazil. J Clin Virol 39: 205-209.
35. Tamura K, Dudley J, Nei M, Kumar S. 2007. MEG A4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol 24: 1596-1599.