Fluoxetine affects antioxidant system and promotes apoptotic signaling in Wistar rat liver

European Journal of Pharmacology

Volumn 659, Issue 1, 2011, Pages 61-66

  Djordjevic, Jelena ^a   Djordjevic, Ana ^a   Adzic, Miroslav ^a   Elaković, Ivana ^b   Matić, Gordana ^b   Radojcic, Marija B ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Antioxidant enzyme; Apoptosis; Fluoxetine; Liver; Stress

Indexed keywords

DNA; FLUOXETINE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; ANTIOXIDANT; PROTEIN BAX; SEROTONIN UPTAKE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CHRONIC STRESS; CONTROLLED STUDY; DEPRESSION; DETOXIFICATION; DNA FRAGMENTATION; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; LIVER METABOLISM; LONG TERM CARE; MALE; MENTAL STRESS; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SOCIAL ISOLATION; UPREGULATION; ANIMAL; CYTOLOGY; DRUG EFFECTS; LIVER; METABOLISM; OXIDATIVE STRESS; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; DNA FRAGMENTATION; FLUOXETINE; GENE EXPRESSION REGULATION; LIVER; MALE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 79958828800     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.03.003     Document Type: Article

References (41)

1. Almeida, O.F.X., Conde, G.L., Crochemore, C., Demeneix, B.A., Fischer, D., Hassan, A.H.S., Meyer, M., Holsboer, F., Michaelidis, T.M., 2000. Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 14, 779-790. (Pubitemid 30198576)
2. Altamura, A.C., Moro, A.R., Percudani, M., 1994. Clinical pharmacokinetics of fluoxetine. Clin. Pharmacokinet. 26, 201-214.
3. Bagchi, M., Bagchi, D., Balmoori, J., Ye, X., Stohs, S.J., 1998. Naphthalene-induced oxidative stress and DNA damage in cultured macrophage J774A.1 cells. Free Radic. Biol. Med. 25, 137-143.
4. Bilici, M., Efe, H., Koroglu, M.A., Uydu, H.A., Bekaroglu, M., Deger, O., 2001. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J. Affect. Disord. 64, 43-51.
5. Cai, Q., Benson, M.A., Talbot, T.J., Devadas, G., Swanson, H.J., Olson, J.L., Kirchner, J.P., 1999. Acute hepatitis due to fluoxetine therapy. Mayo Clin. Proc. 74, 692-694.
6. Claiborne, A., 1985. Handbook of Methods for Oxygene. Radic. Res. 283-284.
7. Crewe, H.K., Lennard, M.S., Tucker, G.T., Woods, F.R., Haddock, R.E., 1992. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Br. J. Clin. Pharmacol. 34, 262-265.
8. Detke, M.J., Johnson, J., Lucki, I., 1997. Acute and Chronic Antidepressant Drug Treatment in the Rat Forced Swimming Test Model of Depression. Exp. Clin. Psychopharmacol. 5, 107-112.
9. Djordjevic, J., Djordjevic, A., Adzic, M., Niciforovic, A., Radojcic, M.B., 2010. Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of Wistar rats. Physiol. Res. 59, 729-736.
10. Elaković, I., Vasiljević, D., Adzic, M., Djordjevic, A., Djordjevic, J., Radojcić, M., Matić, G., 2010. Sexually dimorphic functional alterations of rat hepatic glucocorticoid receptor in response to fluoxetine. Eur. J. Pharmacol. 632, 79-85.
11. Fialkow, L., Wang, Y., Downey, G.P., 2007. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic. Biol. Med. 42, 153-164.
12. Filipkowski, R.K., Hetman, M., Kaminska, B., Kaczmarek, L., 1994. DNA fragmentation in rat brain after intraperitoneal administration of kainate. Neuroreport 5, 1538-1540. (Pubitemid 24251891)
13. Friedenberg, F.K., Rothstein, K.D., 1996. Hepatitis secondary to fluoxetine treatment. Am. J. Psychiatry 153, 580.
14. Galecki, P., Szemraj, J., Bienkiewicz, M., Zboralski, K., Galecka, E., 2009. Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients. Hum. Psychopharmacol. Clin. Exp. 24, 277-286.
15. Grattagliano, I., Portincasa, P., Palmieri, V.O., Palasciano, G., 2002. Overview on the mechanisms of drug-induced liver cell death. Ann. Hepatol. 1, 162-168.
16. Gross, A., McDonnell, J.M., Korsmeyer, S.J., 1999. BCL-2 family members and the mitochondria in apoptosis. Genes Dev. 15, 1899-1911. (Pubitemid 29407357)
17. Herrera, B., Fernandez, M., Alvarez, A.M., Roncero, C., Benito, M., Gil, J., Fabregat, I., 2001. Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome c release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes. Hepatology 34, 548-556. (Pubitemid 32786646)
18. Huether, G., Schuff-Werner, P., 1996. Platelet serotonin acts as a locally releasable antioxidant. Adv. Exp. Med. Biol. 398, 299-306.
19. Johnston, D.E., Wheeler, D.E., 1997. Chronic hepatitis related to use of fluoxetine. Am. J. Gastroenterol. 92, 1225-1226.
20. Kaushik, S., Kaur, J., 2003. Chronic cold exposure affects the antioxidant defense system in various rat tissues. Clin. Chim. Acta 333, 69-77.
21. Khanzode, S.D., Dakhale, G.N., Khanzode, S.S., Saoji, A., Palasodkar, R., 2003. Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors. Redox Rep. 8, 365-370. (Pubitemid 38128544)
22. Kirkova, M., Tzvetanova, E., Vircheva, S., Zamfirova, R., Grygier, B., Kubera, M., 2010. Antioxidant activity of fluoxetine: studies in mice melanoma model. Cell Biochem. Funct. 28, 497-502.
23. Kohen, R., Nyska, A., 2002. Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions and methods for their quantification. Toxicol. Pathol. 30, 620-650.
24. Laemmli, U.K., 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
25. Leonard, B.E., 2001. The immune system, depression and the action of antidepressants. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 767-780.
26. Lucassen, P.J., Fuchs, E., Czeh, B., 2004. Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biol. Psychiatry 55, 789-796. (Pubitemid 38429869)
27. Madrigal, J.L., Olivenza, R., Moro, M.A., Lizasoain, I., Lorenzo, P., Rodrigo, J., Leza, J.C., 2001. Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain. Neuropsychopharmacology 24, 420-429. (Pubitemid 32157558)
28. Markwell, M.A., Haas, S.M., Bieber, L.L., Tolbert, N.E., 1978. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87, 206-210.
29. Murphy, K.M., Ranganathan, V., Farnsworth, M.L., Kavallaris, M., Lock, R.B., 2000. Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ. 7, 102-111. (Pubitemid 30153768)
30. Prabhakar, A.H., Patel, V.B., Giridhar, R., 1999. Spectrophotometric determination of fluoxetine hydrochloride in bulk and in pharmaceutical formulations. J. Pharm. Biomed. Anal. 20, 427-432.
31. Serafeim, A., Holder, M.J., Grafton, G., Chamba, A., Drayson, M.T., Luong, Q.T., Bunce, C.M., Gregory, C.D., Barnes, N.M., Gordon, J., 2003. Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood 101, 3212-3219. (Pubitemid 36858017)
32. Sluzewska, A., Rybakowski, J., Bosmans, E., Sobieska, M., Berghmans, R., Maes, M., Wiktorowicz, K., 1996. Indicators of immune activation inmajor depression. Psychiatr. Res. 64, 161-167.
33. Souza, M.E., Polizello, A.C., Uyemura, S.A., Castro-Silva, O., Curti, C., 1994. Effect of fluoxetine on rat liver mitochondria. Biochem. Pharmacol. 48, 535-541.
34. Thompson, D.C., Perera, K., London, R., 2000. Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation. Chem. Biol. Interact. 126, 1-14.
35. Yang, J., Liu, X., Bhalla, K., Kim, C.N., Ibrado, A.M., Cai, J., Peng, T.I., Jones, D.P., Wang, X., 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275, 1129-1132. (Pubitemid 27097312)
36. Willner, P., 1997. Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology (Berl) 134, 319-329. (Pubitemid 28023396)
37. Wong, D.T., Bymaster, F.P., Engleman, E.A., 1995. Prozac (Fluoxetine, Lilly 11040), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Life Sci. 57, 411-441.
38. Zafir, A., Banu, N., 2007. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Eur. J. Pharmacol. 572, 23-31.
39. Zafir, A., Banu, N., 2009. Induction of oxidative stress by restraint stress and corticosterone treatments in rats. Indian J. Biochem. Biophys. 46, 53-58.
40. Zhai, F.G., Zhang, X.H., Wang, H.L., 2009. Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension: potential roles of induction of apoptosis and upregulation of Kv1.5 channels in rats. Clin. Exp. Pharmacol. Physiol. 36, 850-856.
41. Zimmermann, R., Flohe, L., Weser, U., Hartmann, H.J., 1973. Inhibition of lipid peroxidation in isolated inner membrane of rat liver mitochondria by superoxide dismutase. FEBS Lett. 29, 117-120.