Spontaneous hydrolysis of 4-trifluoromethylphenol to a quinone methide and subsequent protein alkylation

Chemico-Biological Interactions

Volumn 126, Issue 1, 2000, Pages 1-14

  Thompson, David C ^a   Perera, Kumar ^a   London, Robert ^b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

4 TFMP; Protein alkylation; Quinone methide

Indexed keywords

1,4 BENZOQUINONE; 4 TRIFLUOROMETHYLPHENOL; FLUORIDE SODIUM; GLUTATHIONE; PHENOL DERIVATIVE; POTASSIUM FLUORIDE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CYTOTOXICITY; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIVER TOXICITY; MALE; MAMMAL CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN MODIFICATION; RAT;

ALKYLATION; ANIMALS; ENZYME INHIBITORS; FLUORIDES; GLUTATHIONE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HYDROLYSIS; INDOLEQUINONES; INDOLES; LIVER; MALE; PHENOLS; PROTEINS; QUINONES; RATS; RATS, SPRAGUE-DAWLEY;

TRIXIS;

EID: 0034647001     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00162-3     Document Type: Article

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