Monoclonal antibodies against nucleophosmin mutants: Potentials for the detection of acute myeloid leukemia

International Journal of Medical Sciences

Volumn 8, Issue 4, 2011, Pages 309-314

  Tan, Shi ^a   Zhang, Ling ^a   Zhong, Xiao Ming ^a   Yang, Zai Lin ^b   Zhao, Liu Yang ^a   Gao, Yu Jie ^a   Shao, Hui Yuan ^a   Qin, Feng Xian ^a   Chen, Xian Chun ^a   Zhang, Hui Juan ^a   Chen, Hui ^a   Wang, Li ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Acute leukemia; Monoclonal antibody; Nucleophosmin mutants; Recombinant protein

Indexed keywords

MONOCLONAL ANTIBODY; NUCLEOPHOSMIN; RECOMBINANT PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; GENE; GENE MUTATION; GENE VECTOR; HUMAN; HUMAN TISSUE; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; MOUSE; MUTANT; NONHUMAN; NPM1 GENE; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROTEIN EXPRESSION; WILD TYPE;

EID: 79958828568     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.8.309     Document Type: Article

References (27)

1. Borer RA, Lehner CF, Eppenberger HM, et al. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell. 1989; 56: 379-90.
2. Nishimura Y, Ohkubo T, Furuichi Y, et al. Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization. Biosci Biotechnol Biochem. 2002; 66: 2239-42.
3. Schnittger S, Schoch C, Kern W, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute mye-logenous leukemia with a normal karyotype. Blood. 2005; 106: 3733-9.
4. Boissel N, Renneville A, Biggio V, et al. Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. Blood. 2005; 106: 3618-20.
5. Falini B, Nicoletti I, Martelli MF, et al. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood. 2007; 109: 874-85.
6. Liso A, Bogliolo A, Freschi V, et al. In human genome, genera-tion of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML. Leukemia. 2008; 22: 1285-9.
7. Falini B, Bolli N, Shan J, et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear ex-port of nucleophosmin leukemic mutants in NPMc+ AML. Blood. 2006; 107: 4514-23.
8. Chou WC, Tang JL, Lin LI, et al. Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution. Cancer Res. 2006; 66: 3310-6.
9. Palmisano M, Grafone T, Ottaviani E, et al. NPM1 mutations are more stable than FLT3 mutations during the course of dis- ease in patients with acute myeloid leukemia. Haematologica. 2007; 92:1268-9.
10. Falini B, Martelli MP, Bolli N, et al. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity? Blood. 2011; 117: 1109-20.
11. Becker H, Marcucci G, Maharry K, et al. Favorable prognostic impact of NPM1 mutations in older patients with cytogenet-ically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study. J Clin Oncol. 2010; 28: 596-604.
12. Vardiman JW, Thiele J, Arber DA, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. 2009; 114:937-51.
13. Pasqualucci L, Liso A, Martelli MP, et al. Mutated nucleo-phosmin detects clonal multilineage involvement in acute my-eloid leukemia: Impact on WHO classification. Blood. 2006; 108:4146-55.
14. Papadaki C, Dufour A, Seibl M, et al. Monitoring minimal residual disease in acute myeloid leukaemia with NPM1 muta-tions by quantitative PCR: clonal evolution is a limiting factor. Br J Haematol. 2009; 144: 517-23.
15. Noguera NI, Ammatuna E, Zangrilli D, et al. Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary elec-trophoresis in acute myeloid leukemia. Leukemia. 2005; 19:1479-82.
16. Falini B, Mason DY. Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry. Blood. 2002; 99: 409-26.
17. Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005; 352: 254-66.
18. Falini B, Martelli MP, Bolli N, et al. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood. 2006; 108:1999-2005.
19. Cordell JL, Pulford KA, Bigerna B, et al. Detection of normal and chimeric nucleophosmin in human cells. Blood. 1999; 93: 632-42.
20. Konoplev S, Huang X, Drabkin HA, et al. Cytoplasmic locali-zation of nucleophosmin in bone marrow blasts of acute mye-loid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis. Cancer. 2009; 115: 4737-44.
21. Thiede C, Koch S, Creutzig E, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006; 107: 4011-20.
22. Falini B, Sportoletti P, Martelli MP. Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives. Curr Opin Oncol. 2009; 21: 573-81.
23. Falini B, Martelli MP, Pileri SA, et al. Molecular and alternative methods for diagnosis of acute myeloid leukemia with mutated NPM1: flexibility may help. Haematologica. 2010; 95: 529-34.
24. Ochs R, Lischwe M, O'Leary P, et al. Localization of nucleolar phosphoproteins B23 and C23 during mitosis. Exp Cell Res. 1983; 146:139-49.
25. Falini B, Bolli N, Liso A, et al. Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications. Leukemia. 2009; 23:1731-43.
26. Gruszka AM, Lavorgna S, Consalvo MI, et al. A monoclonal antibody against mutated nucleophosmin1 for the molecular diagnosis of acute myeloid leukemias. Blood. 2010; 116: 2096-102.
27. Mattsson G, Turner SH, Cordell J, et al. Can cytoplasmic nu-cleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia? Haematologica. 2010; 95: 670-3.