Can cytoplasmic nucleophosmin be detected by immunocytochemical staining of cell smears in acute myeloid leukemia?

Haematologica

Volumn 95, Issue 4, 2010, Pages 670-673

  Mattsson, Göran ^a,b   Turner, Susan H ^c   Cordell, Jacqueline ^a   Ferguson, David J P ^a   Schuh, Anna ^c   Grimwade, Lizz F ^d   Bench, Anthony J ^d   Weinberg, Olga K ^e   Marafioti, Teresa ^a   George, Tracy I ^e   Arber, Daniel A ^e   Erber, Wendy N ^d   Mason, David Y ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b AGILENT TECHNOLOGIES   (United States)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AML; Blood smears; Mutation; Nucleophosmin; OCI AML3

Indexed keywords

ALKALINE PHOSPHATASE; NUCLEOPHOSMIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLAST CELL; BONE MARROW BIOPSY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL; LEUKEMIA CELL LINE; MAJOR CLINICAL STUDY; NUCLEOLUS; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; WILD TYPE;

BONE MARROW; CYTOLOGICAL TECHNIQUES; CYTOPLASM; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKEMIA, MYELOID, ACUTE; MUTATION; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROGNOSIS;

EID: 77950685471     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.011817     Document Type: Article

References (25)

1. Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352(3):254-66
2. Arber D, Brunning R, LeBeau M, Falini B, Vardiman J, Porwit A, et al. Acute Myeloid Leukaemia with Recurrent Genetic Abnormalities. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, et al., eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Geneva, Switzerland: IARC Press, 2008
3. Falini B, Nicoletti I, Martelli M, Mecucci C. Acute myeloid leukemia carrying cytoplasmic/ mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood. 2007;109(3):874-5
4. Haferlach C, Mecucci C, Schnittger S, Kohlmann A, Mancini M, Cuneo A, et al. AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biological, pathological, immunophenotypic, and prognostic features. Blood. 2009;114(14):3024-32
5. Döhner K, Schlenk R, Habdank M, Scholl C, Rücker F, Corbacioglu A, et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood. 2005;106(12):3740-6
6. Schnittger S, Schoch C, Kern W, Mecucci C, Tschulik C, Martelli M, et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood. 2005;106(12):3733-9
7. Verhaak R, Goudswaard C, van Putten W, Bijl M, Sanders M, Hugens W, et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood. 2005;106(12):3747-54
8. Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, et al. Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood. 2006;107(10): 4011-20
9. Falini B, Martelli M, Bolli N, Bonasso R, Ghia E, Pallotta M, et al. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood. 2006;108(6): 1999-2005
10. Carter B, Mak D, Schober W, McQueen T, Harris D, Estrov Z, et al. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood. 2006;108(2):630-7
11. Cordell J, Pulford K, Bigerna B, Roncador G, Banham A, Colombo E, et al. Detection of normal and chimeric nucleophosmin in human cells. Blood. 1999;93(2):632-42
12. Falini B, Bolli N, Bhan J, Martelli M, Liso A, Pucciarini A, et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood. 2006;107(11):4514-23
13. Pasqualucci L, Liso A, Martelli M, Bolli N, Pacini R, Tabarrini A, et al. Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification. Blood. 2006;108(13):4146-55
14. Cordell J, Falini B, Erber W, Ghosh A, Abdulaziz Z, MacDonald S, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984;32(2):219-29
15. Mattsson G, Tan S, Ferguson D, Erber W, Turner S, Marafioti T, et al. Detection of genetic alterations by immunoFISH analysis of whole cells extracted from routine biopsy material. J Mol Diagn. 2007;9(4):479-89
16. Boissel N, Renneville A, Biggio V, Philippe N, Thomas X, Cayuela J, et al. Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. Blood. 2005;106(10):3618-20
17. Lin L, Lin T, Chou W, Tang J, Lin D, Tien H. A novel fluorescence-based multiplex PCR assay for rapid simultaneous detection of CEBPA mutations and NPM mutations in patients with acute myeloid leukemias. Leukemia. 2006;20(10):1899-903
18. Weinberg O, Seetharam M, Ren L, Seo K, Ma L, Merker J, et al. Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system. Blood. 2009;113(9):1906-8
19. Ferguson D, Cesbron-Delauw M, Dubremetz J, Sibley L, Joiner K, Wright S. The expression and distribution of dense granule proteins in the enteric (Coccidian) forms of Toxoplasma gondii in the small intestine of the cat. Exp Parasitol. 1999; 91(3):203-11
20. Quentmeier H, Martelli M, Dirks W, Bolli N, Liso A, Macleod R, et al. Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin. Leukemia. 2005;19(10): 1760-7
21. Ochs R, Lischwe M, O'Leary P, Busch H. Localization of nucleolar phosphoproteins B23 and C23 during mitosis. Exp Cell Res. 1983;146(1):139-49
22. Mason D, Pulford K, Bischof D, Kuefer M, Butler L, Lamant L, et al. Nucleolar localization of the nucleophosmin-anaplastic lymphoma kinase is not required for malignant transformation. Cancer Res. 1998;58(5): 1057-62
23. Falini B, Bolli N, Liso A, Martelli MP, Mannucci R, Pileri S, et al. Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications. Leukemia. 2009;23(10):1731-43
24. Torlakovic EE, Naresh K, Kremer M, van der Walt J, Hyjek E, Porwit A. Call for a European programme in external quality assurance for bone marrow immunohistochemistry; report of a European Bone Marrow Working Group pilot study. J Clin Pathol. 2009;62(6):547-51
25. Oelschlaegel U, Koch S, Schaich M, Kroschinsky F, Parmentier S, Ehninger G, et al. A rapid flow cytometric method for the detection of NPM1 mutated patients with acute myeloid leukaemia (AML). Blood. 2008(112):Abstract 1490.