In vitro screening of taxol, an anticancer drug produced by the fungus, Colletotrichum capsici

Engineering in Life Sciences

Volumn 11, Issue 3, 2011, Pages 264-271

  Kumaran, Rangarajulu Senthil ^a   Jung, Heehoon ^a   Kim, Hyung Joo ^a  

^a Konkuk University   (South Korea)

Author keywords

Cytotoxicity test; Fungal taxol production; Taxadiene synthase gene

Indexed keywords

ALTERNATE SOURCE; ANTICANCER DRUG; CAPSICUM ANNUUM; CHROMATOGRAPHIC METHODS; CYTOTOXIC ACTIVITIES; CYTOTOXICITY TEST; HUMAN CANCER CELLS; IN-VITRO; LIQUID MEDIUM; MOLECULAR CHARACTERISTICS; PRODUCTION RATES; TAXADIENE SYNTHASE; TAXOL PRODUCTION;

BIOCHEMISTRY; CELL CULTURE; CELL DEATH; CHROMATOGRAPHIC ANALYSIS; FUNGI; GENES; GENETIC ENGINEERING;

CYTOTOXICITY;

PACLITAXEL; SYNTHETASE; TAXADIENE SYNTHASE; UNCLASSIFIED DRUG;

CANCER; CHROMATOGRAPHY; DRUG DEVELOPMENT; ENZYME ACTIVITY; FRUIT; FUNGAL DISEASE; FUNGUS; GENETIC ENGINEERING; LIQUID CHROMATOGRAPHY; MOLECULAR ANALYSIS; MORPHOLOGY; POLYMERASE CHAIN REACTION; VEGETABLE;

ARTICLE; BACTERIAL GENE; CANCER CELL CULTURE; CELL DEATH; COLLETOTRICHUM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; FUNGAL MORPHOLOGY; FUNGUS; FUNGUS IDENTIFICATION; FUNGUS ISOLATION; GENETIC ENGINEERING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; LIQUID CULTURE; MASS SPECTROMETRY; NONHUMAN; PEPPER; POLYMERASE CHAIN REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; TAXOMYCES ANDREANAE; THIN LAYER CHROMATOGRAPHY;

CAPSICUM ANNUUM; COLLETOTRICHUM CAPSICI; FUNGI;

EID: 79958807918     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.201000119     Document Type: Article

References (30)

1. Ross, J. L., Santangelo, C. D., Makrides, V., Fygenson, D. K., Tau induces cooperative taxol binding to microtubules. Proc. Natl. Acad. Sci. USA 2004, 101, 12910-12915.
2. Yuan, J., Jian-Nan, B., Bing, Y., Xu-Dong, Z., Taxol-producing fungi: A new approach to industrial production of taxol. Chin. J. Biotech. 2006, 22, 1-6.
3. Kumaran, R. S., Muthumary, J., Hur, B. K., Taxol from Phyllosticta citricarpa, a leaf spot fungus of an angiosperm, Citrus medica. J. Biosci. Bioeng. 2008, 106, 103-106.
4. Kumaran, R. S., Muthumary, J., Hur, B. K., Isolation and detection of an anticancer drug, taxol from Phyllosticta tabernaemontane, a leaf spot fungus of an angiosperm, Wrightia tinctoria, J. Microbiol. 2009, 47, 47-56.
5. Kathiravan, G., Raman, V. S., In vitro taxol production, by Pestalotiopsis breviseta - a first report. Fitoterapia 2010, 81, 557-564.
6. Kumaran, R. S., Muthumary, J., Kim, E. K., Hur, B. K., Production of taxol from Phyllosticta dioscoreae, a leaf spot fungus isolated from Hibiscus rosa-sinensis. Biotechnol. Bioprocess Eng. 2009, 14, 76-83.
7. Zhou, X., Zhu, H., Liu, L., Lin, J., Tang, K., A review: recent advances and future prospects of taxol-producing endophytic fungi. Appl. Microbial. Biotechnol. 2010, 86, 107-1717.
8. Kumaran, R. S., Muthumary, J., Hur, B. K., Isolation and identification of taxol, an anticancer drug from Phyllosticta melochiae Yates, an endophytic fungus of Melochia corchorifolia L. Food Sci. Biotechnol. 2008, 17, 1246-1253.
9. Stierle, A., Strobel, G. A., Stierle, D., Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of pacific yew. Science 1993, 260, 214-216.
10. Kumaran, R. S., Hur, B. K., Screening of species of the endophytic fungus Phomopsis for the production of the anticancer drug taxol. Biotechnol. Appl. Biochem. 2009, 54, 21-30.
11. Strobel, G. A., Hess, W. M., Ford, E., Sidhu, R. S., Yang, X., Taxol from fungal endophytes and the issue of biodiversity. J. Ind. Microbiol. 1996, 17, 417-423.
12. Liu, K., Ding, X., Deng, B., Chen, W., Isolation and characterization of endophytic taxol-producing fungi from Taxus chinensis. J. Ind. Microbiol. Biotechnol. 2009, 36, 1171-1177.
13. Zhou, X., Wang, Z., Jiang, K., Wei, Y. et al., Screening of taxol producing endophytic fungi from Taxus chinensis var. mairei. Appl. Biochem. Microbiol. 2007, 43, 439-443.
14. Kumaran, R. S., Gomathi, V., Kannabiran, B., Effect of Abrus precatorius and Rauvolfia tetraphylla root extracts on the cellulolytic and pectinolytic activities of Colletotrichum capsici. KAVAKA 2001, 29, 93-99.
15. Sharma, P. N., Kaur, M., Sharma, O. P., Sharma, P., Pathania, A., Morphological, pathological and molecular variability in Colletotrichum capsici, the cause of fruit rot of chillies in the subtropical region of north-western India. J. Phytopathol. 2005, 153, 232-237.
16. Huang, T. P., Yeh, Y., Tzeng, D. D. S., Heteroduplex mobility assay for identification and phylogenetic analysis of anthracnose fungi. J. Phytopathol. 2010, 158, 46-55.
17. Kumaran, R. S., Muthumary, J., Hur, B. K., Production of taxol from Phyllosticta spinarum, an endophytic fungus of Cupressus sp. Eng. Life Sci. 2008, 8, 438-446.
18. Ruckdeschel, K., Roggenkamp, A., Lafont, V., Mangeat, P., et al., Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis. Infect. Immun. 1997, 65, 4813-4821.
19. Sutton, B. C., The Coelomycetes: Fungi Imperfecti with Pycnidia, Acervuli and Stromata, Commonwealth Mycological Institute, England 1980, p. 537.
20. Kumaran, R. S., Kim, H. J., Hur, B. K., Taxol promising fungal endophytes, Pestalotiopsis species isolated from Taxus cuspidate. J. Biosci. Bioeng. 2010, 110, 541-546.
21. Chow, S. Y., Williams, H. J., Pennington, J. D., Nanda, S. et al., Studies on taxadiene synthase: interception of the cyclization cascade at the verticillene stage and rearrangement to phomactatriene. Tetrahedron 2007, 63, 6204-6209.
22. Walker, K., Croteau, R., Molecules of interest: Taxol biosynthetic genes. Phytochemistry 2001, 58, 1-7.
23. Huang, K. X., Huang, Q. L., Wildung, M. R., Croteau, R., Scott, A. I., Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the taxol biosynthetic pathway. Protein Expr. Purif. 1998, 13, 90-96.
24. Williams, D. C., Wildung, M. R., Jin, A. Q., Dalal, D. et al., Heterologous expression and characterization of a pseudomature form of taxadiene synthase involved in paclitaxel (taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. Arch. Biochem. Biophys. 2000, 379, 137-146.
25. Zhang, P., Zhou, P. P., Jiang, C., Yu, H., Yu, L. J., Screening of taxol producing fungi based on PCR amplification from Taxus. Biotechnol. Lett. 2008, 30, 2119-2123.
26. 13C-NMR assignments for taxol, 7-epi-taxol and cephalomannine. J. Nat. Prod. 1992, 55, 414-423.
27. McClure, T. D., Schram, K. H., The mass spectrometry of taxol. J. Am. Soc. Mass Spectrom. 1992, 3, 672-679.
28. Strobel, G. A., Yang, X., Sears, J., Kramer, R. et al., Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana. Microbiology 1996, 142, 435-440.
29. Strobel, G. A., Hess, W. M., Li, J. Y., Sears, J. et al., Pestalotiopsis guepinii, a taxol producing endophyte of wollemi pine, Wollemia nobilis. Aust. J. Bot. 1997, 45, 1073-1082.
30. Yeung, T. K., Germond, C., Chen, X., Wang, Z., The mode of action of taxol: apoptosis at low concentration and necrosis at high concentration. Biochem. Biophy. Res. Comm. 1999, 263, 398-404.