메뉴 건너뛰기




Volumn 126, Issue 1-2, 2011, Pages 1-9

The metabolism of 20-hydroxyecdysone in mice: Relevance to pharmacological effects and gene switch applications of ecdysteroids

Author keywords

20 Hydroxyecdysone; Ecdysteroid; Mammal; Metabolism

Indexed keywords

14 DEOXY 20 HYDROXYECDYSONE; 14 DEOXYPOSTSTERONE; 2BETA,3BETA,6ALPHA,25 PENTAHYDROXY 5BETA CHOLEST 8(14) ENE; DRUG METABOLITE; ECDYSTEROID; ECDYSTERONE; POSTSTERONE; STEROID HORMONE; UNCLASSIFIED DRUG;

EID: 79958795171     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.03.016     Document Type: Article
Times cited : (40)

References (49)
  • 1
    • 0002545589 scopus 로고
    • Ecdysteroids in vertebrates: Pharmalogical aspects
    • P. Simon, and J. Koolman Ecdysteroids in vertebrates: pharmalogical aspects J. Koolman, Ecdysone - From Chemistry to Mode of Action 1989 Georg Thieme Verlag Stuttgart 254 259
    • (1989) Ecdysone - From Chemistry to Mode of Action , pp. 254-259
    • Simon, P.1    Koolman, J.2
  • 2
    • 0000974755 scopus 로고
    • Insect hormones - Ecdysteroids: Their presence and actions in vertebrates
    • K. Sláma, and R. Lafont Insect hormones - ecdysteroids: their presence and actions in vertebrates Eur. J. Entomol. 92 1995 355 377
    • (1995) Eur. J. Entomol. , vol.92 , pp. 355-377
    • Sláma, K.1    Lafont, R.2
  • 3
    • 0034521024 scopus 로고    scopus 로고
    • Comparative experimental investigation of the anabolic activity of phytoecdysteroids and steranabols
    • V.N. Syrov Comparative experimental investigations of the anabolic activity of ecdysteroids and steranabols Pharmaceut. Chem. J. 34 2000 193 197 (Pubitemid 32050899)
    • (2000) Pharmaceutical Chemistry Journal , vol.34 , Issue.4 , pp. 193-197
    • Syrov, V.N.1
  • 4
    • 0036594245 scopus 로고    scopus 로고
    • Phytoecdysteroids effects on mammalians, isolation and analysis
    • M. Báthori Phytoecdysteroids effects on mammalians, isolation and analysis Mini-Rev. Med. Chem. 2 2002 285 293
    • (2002) Mini-Rev. Med. Chem. , vol.2 , pp. 285-293
    • Báthori, M.1
  • 5
    • 2442649769 scopus 로고    scopus 로고
    • Practical uses for ecdysteroids in mammals including humans: An update
    • R. Lafont, and L. Dinan Practical uses for ecdysteroids in mammals including humans: an update J. Insect Sci. 3 3/7 2003 (available at insectscience.org/3.7)
    • (2003) J. Insect Sci. , vol.3 , Issue.3-7
    • Lafont, R.1    Dinan, L.2
  • 6
    • 33751054112 scopus 로고    scopus 로고
    • Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals
    • DOI 10.1677/joe.1.06900
    • L. Dinan, and R. Lafont Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals J. Endocrinol. 191 2006 1 8 (Pubitemid 44756502)
    • (2006) Journal of Endocrinology , vol.191 , Issue.1 , pp. 1-8
    • Dinan, L.1    Lafont, R.2
  • 7
    • 39049112601 scopus 로고    scopus 로고
    • Phytoecdysteroids and anabolic-androgenic steroids - Structure and effects on humans
    • DOI 10.2174/092986708783330674
    • M. Báthori, N. Tóth, A. Hunyadi, A. Márki, and E. Zador Phytoecdysteroids and anabolic-androgenic steroids - structure and effects on humans Curr. Med. Chem. 15 2008 75 91 (Pubitemid 351234629)
    • (2008) Current Medicinal Chemistry , vol.15 , Issue.1 , pp. 75-91
    • Bathori, M.1    Toth, N.2    Hunyadi, A.3    Marki, A.4    Zador, E.5
  • 8
    • 0035371607 scopus 로고    scopus 로고
    • Phytoecdysteroids: Biological aspects
    • DOI 10.1016/S0031-9422(01)00078-4, PII S0031942201000784
    • L. Dinan Phytoecdysteroids: biological aspects Phytochemistry 57 2001 325 339 (Pubitemid 32448444)
    • (2001) Phytochemistry , vol.57 , Issue.3 , pp. 325-339
    • Dinan, L.1
  • 9
    • 41049112176 scopus 로고
    • Ecdysones used to improve productivity of ruminants
    • PCT Int. Appl. WO 94 18,984, AU Appl. 93/7,397
    • D.B. Purser, S.K. Baker, Ecdysones used to improve productivity of ruminants. PCT Int. Appl. WO 94 18,984, AU Appl. 93/7,397, Chem. Abstr. 121 (1994) 254587.
    • (1994) Chem. Abstr. , vol.121 , pp. 254-587
    • Purser, D.B.1    Baker, S.K.2
  • 10
    • 0029797313 scopus 로고    scopus 로고
    • Insect hormones in vertebrates: Anabolic effects of 20-hydroxyecdysone in Japanese quail
    • K. Sláma, K. Koudela, J. Tenora, and A. Mathova Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quails Experientia 52 1996 702 706 (Pubitemid 26318630)
    • (1996) Experientia , vol.52 , Issue.7 , pp. 702-706
    • Slam, K.1    Koudela, K.2    Tenora, J.3    Mathova, A.4
  • 11
    • 2942755161 scopus 로고    scopus 로고
    • Effect of 20-hydroxyecdysone on the protein synthesis of pigs
    • F. Kratky, L. Opletal, J. Hejhalek, and S. Kucharova Effect of 20-hydroxyecdysone on the protein synthesis of pigs Zivocisna Vyroba 42 1997 445 451
    • (1997) Zivocisna Vyroba , vol.42 , pp. 445-451
    • Kratky, F.1    Opletal, L.2    Hejhalek, J.3    Kucharova, S.4
  • 12
    • 0014386149 scopus 로고
    • Stimulatory effect of insect metamorphosing steroids from Achyranthes and Cyathula on protein synthesis in mouse liver
    • T. Otaka, M. Uchiyama, S. Okui, T. Takemoto, H. Hikino, S. Ogawa, and N. Nishimoto Stimulatory effect of insect metamorphosing steroids from Achyranthes and Cyathula on protein synthesis in mouse liver Chem. Pharm. Bull. 16 1968 2426 2429
    • (1968) Chem. Pharm. Bull. , vol.16 , pp. 2426-2429
    • Otaka, T.1    Uchiyama, M.2    Okui, S.3    Takemoto, T.4    Hikino, H.5    Ogawa, S.6    Nishimoto, N.7
  • 15
    • 0037175526 scopus 로고    scopus 로고
    • Ecdysteroids: One potential new anabolic family in breeding animals
    • DOI 10.1016/S0003-2670(02)00874-7, PII S0003267002008747
    • B. Le Bizec, J.P. Antignac, F. Monteau, and F. André Ecdysteroids: one potential new anabolic family in breeding animals Anal. Chim. Acta 473 2002 89 97 (Pubitemid 35335418)
    • (2002) Analytica Chimica Acta , vol.473 , Issue.1-2 , pp. 89-97
    • Le Bizec, B.1    Antignac, J.-P.2    Monteau, F.3    Andre, F.4
  • 16
    • 60149112951 scopus 로고    scopus 로고
    • Detection of 20-hydroxyecdysone in calf urine by comparative liquid chromatography/high resolution mass spectrometry and liquid chromatography/ tandem mass spectrometry measurements: Application to the control of the potential misuse of ecdysteroids in cattle
    • B. Destrez, G. Pinel, E. Bichon, F. Monteau, R. Lafont, and B. Le Bizec Detection of 20-hydroxyecdysone in calf urine by comparative liquid chromatography/high resolution mass spectrometry and liquid chromatography/ tandem mass spectrometry measurements: application to the control of the potential misuse of ecdysteroids in cattle Rapid Commun. Mass Spectrom. 22 2008 4073 4080
    • (2008) Rapid Commun. Mass Spectrom. , vol.22 , pp. 4073-4080
    • Destrez, B.1    Pinel, G.2    Bichon, E.3    Monteau, F.4    Lafont, R.5    Le Bizec, B.6
  • 17
    • 61849180390 scopus 로고    scopus 로고
    • Detection and identification of 20-hydroxyecdysone metabolites in calf urine by liquid chromatography-high resolution or tandem mass spectrometry measurements and establishment of their kinetics of elimination after 20-hydroxyecdysone administration
    • B. Destrez, G. Pinel, F. Monteau, R. Lafont, and B. Le Bizec Detection and identification of 20-hydroxyecdysone metabolites in calf urine by liquid chromatography-high resolution or tandem mass spectrometry measurements and establishment of their kinetics of elimination after 20-hydroxyecdysone administration Anal. Chim. Acta 637 2009 178 184
    • (2009) Anal. Chim. Acta , vol.637 , pp. 178-184
    • Destrez, B.1    Pinel, G.2    Monteau, F.3    Lafont, R.4    Le Bizec, B.5
  • 19
    • 0023845584 scopus 로고
    • Excretion and metabolism of injected ecdysone in the white mouse
    • DOI 10.1016/0006-2952(88)90529-1
    • R. Lafont, J.P. Girault, and U. Kerb Excretion and metabolism of injected ecdysone in the white mouse Biochem. Pharmacol. 37 1988 1174 1177 (Pubitemid 18066477)
    • (1988) Biochemical Pharmacology , vol.37 , Issue.6 , pp. 1174-1177
    • Lafont, R.1    Girault, J.-P.2    Kerb, U.3
  • 20
    • 2942757383 scopus 로고    scopus 로고
    • Study of ecdysterone metabolites isolated from rat urine
    • N. Ramazanov, Z. Saatov, and V.N. Syrov Study of ecdysterone metabolites isolated from rat urine Khim. Prir. Soedin. 4 1996 558 564
    • (1996) Khim. Prir. Soedin. , Issue.4 , pp. 558-564
    • Ramazanov, N.1    Saatov, Z.2    Syrov, V.N.3
  • 22
    • 0036147085 scopus 로고    scopus 로고
    • Photochemical transformation of 20-hydroxyecdysone: Production of monomeric and dimeric ecdysteroid analogues
    • DOI 10.1016/S0039-128X(01)00140-4, PII S0039128X01001404
    • J. Harmatha, M. Budesínsky, and K. Vokác Photochemical transformation of 20-hydroxyecdysone: production of monomeric and dimeric ecdysteroid analogues Steroids 67 2002 127 135 (Pubitemid 34081831)
    • (2002) Steroids , vol.67 , Issue.2 , pp. 127-135
    • Harmatha, J.1    Budes, M.2    Vokac, K.3
  • 23
    • 0036261493 scopus 로고    scopus 로고
    • The selective dehydroxylation of 20-hydroxyecdysone by Zn powder and anhydrous acetic acid
    • DOI 10.1081/SCC-120003635
    • W.M. Zhu, H.J. Zhu, W.S. Tian, X.J. Hao, and C.U. Pittman Jr. The selective dehydroxylation of 20-hydroxyecdysone by Zn powder and anhydrous acetic acid Synthetic Commun. 32 2002 1385 1391 (Pubitemid 34556498)
    • (2002) Synthetic Communications , vol.32 , Issue.9 , pp. 1385-1391
    • Zhu, W.-M.1    Zhu, H.-J.2    Tian, W.-S.3    Hao, X.-J.4    Pittman Jr., C.U.5
  • 24
    • 0007006261 scopus 로고
    • Jones' oxidation of 20-hydroxyecdysone (crustecdysone)
    • Q.R. Petersen, R.C. Cambie, and G.B. Russel Jones' oxidation of 20-hydroxyecdysone (crustecdysone) Aust. J. Chem. 46 1993 1961 1964
    • (1993) Aust. J. Chem. , vol.46 , pp. 1961-1964
    • Petersen, Q.R.1    Cambie, R.C.2    Russel, G.B.3
  • 25
    • 33845636158 scopus 로고    scopus 로고
    • Stereoselective synthesis and moulting activity of integristerone A and analogues
    • DOI 10.1016/j.tet.2006.11.063, PII S0040402006018801
    • S. Kumpun, B. Yingyongnarongkul, J.P. Girault, R. Lafont, and A. Suksamrarn Stereoselective synthesis and moulting hormone activity of integristerone A and analogues Tetrahedron 63 2007 1093 1099 (Pubitemid 44958908)
    • (2007) Tetrahedron , vol.63 , Issue.5 , pp. 1093-1099
    • Kumpun, S.1    Yingyongnarongkul, B.-E.2    Lafont, R.3    Girault, J.-P.4    Suksamrarn, A.5
  • 27
    • 0020029848 scopus 로고
    • Sample processing for high-performance liquid chromatography of ecdysteroids
    • R. Lafont, J.L. Pennetier, M. Andrianjafintrimo, J. Claret, J.F. Modde, and C. Blais Sample processing for high-performance liquid chromatography of ecdysteroids J. Chromatogr. 236 1982 137 149 (Pubitemid 12110373)
    • (1982) Journal of Chromatography , vol.236 , Issue.1 , pp. 137-149
    • Lafont, R.1    Pennetier, J.-L.2    Andrianjafintrimo, M.3
  • 28
    • 0000764094 scopus 로고
    • 1H-NMR assignment of ecdysone and 20-hydroxyecdysone
    • 1H-NMR assignment of ecdysone and 20-hydroxyecdysone J. Insect Physiol. 34 1988 701 706
    • (1988) J. Insect Physiol. , vol.34 , pp. 701-706
    • Girault, J.P.1    Lafont, R.2
  • 29
    • 0032389072 scopus 로고    scopus 로고
    • Determination of ecdysteroid structure by 1D and 2D NMR
    • J.P. Girault Determination of ecdysteroid structure by 1D and 2D NMR Russian J. Plant Physiol. 45 1998 306 309
    • (1998) Russian J. Plant Physiol. , vol.45 , pp. 306-309
    • Girault, J.P.1
  • 30
    • 0015378078 scopus 로고
    • Absorption, distribution, metabolism and excretion of insect-metamorphosing hormone ecdysterone in mice. i
    • H. Hikino, Y. Ohizumi, and T. Takemoto Absorption, distribution, metabolism and excretion of insect-metamorphosing hormone ecdysterone in mice. I Yakugaku Zasshi 92 1972 945 950
    • (1972) Yakugaku Zasshi , vol.92 , pp. 945-950
    • Hikino, H.1    Ohizumi, Y.2    Takemoto, T.3
  • 31
    • 0015424384 scopus 로고
    • Absorption, distribution, metabolism and excretion of insect-metamorphosing hormone ecdysterone in mice. II
    • H. Hikino, Y. Ohizumi, and T. Takemoto Absorption, distribution, metabolism and excretion of insect-metamorphosing hormone ecdysterone in mice. II Chem. Pharm. Bull. 20 1972 2454 2458
    • (1972) Chem. Pharm. Bull. , vol.20 , pp. 2454-2458
    • Hikino, H.1    Ohizumi, Y.2    Takemoto, T.3
  • 34
    • 0009261915 scopus 로고
    • 14-Deoxyecdysteroids in an insect (Gryllus bimaculatus)
    • K.H. Hoffmann, E. Thiry, and R. Lafont 14-Deoxyecdysteroids in an insect (Gryllus bimaculatus) Z. Naturforsch. 45c 1990 703 708
    • (1990) Z. Naturforsch. , vol.45 , pp. 703-708
    • Hoffmann, K.H.1    Thiry, E.2    Lafont, R.3
  • 36
    • 0023505288 scopus 로고
    • Bacterial metabolism of natural and synthetic sex hormones undergoing enterohepatic circulation
    • J. Winter, and V.D. Bokkenheuser Bacterial metabolism of natural and synthetic sex hormones undergoing enterohepatic circulation J. Steroid Biochem. 27 1987 1145 1149
    • (1987) J. Steroid Biochem. , vol.27 , pp. 1145-1149
    • Winter, J.1    Bokkenheuser, V.D.2
  • 38
    • 25944467420 scopus 로고
    • Microbial oxidation of ecdysones. A convenient preparation of rubrosterone
    • W.M. Tom, Y.J. Abul-Hajj, and M. Koreeda Microbial oxidation of ecdysones. A convenient preparation of rubrosterone J. Chem. Soc., Chem. Commun. 1975 24 25
    • (1975) J. Chem. Soc., Chem. Commun. , pp. 24-25
    • Tom, W.M.1    Abul-Hajj, Y.J.2    Koreeda, M.3
  • 39
    • 0015167548 scopus 로고
    • The excretion of steroid hormone metabolites in bile and feces
    • W. Taylor The excretion of steroid hormone metabolites in bile and feces Vitam. Horm. 29 1971 201 285
    • (1971) Vitam. Horm. , vol.29 , pp. 201-285
    • Taylor, W.1
  • 41
    • 2342462928 scopus 로고    scopus 로고
    • Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes
    • DOI 10.1016/j.cbi.2004.01.006, PII S0009279704000080
    • L. You Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes Chem. -Biol. Interact. 147 2004 233 246 (Pubitemid 38591494)
    • (2004) Chemico-Biological Interactions , vol.147 , Issue.3 , pp. 233-246
    • You, L.1
  • 42
    • 0031886788 scopus 로고    scopus 로고
    • Enhancement of GABA-mediated inhibition of rat medial vestibular nucleus neurons by the neurosteroid 20-hydroxyecdysone
    • DOI 10.1080/00016489850155062
    • M. Okada, K. Ishihara, M. Sasa, R. Izumi, K. Yajin, and Y. Harada Enhancement of GABA-mediated inhibition of rat medial vestibular nucleus neurons by the neurosteroid 20-hydroxyecdysone Acta Otolaryngol. (Stockholm) 118 1998 11 16 (Pubitemid 28099988)
    • (1998) Acta Oto-Laryngologica , vol.118 , Issue.1 , pp. 11-16
    • Okada, M.1    Ishihara, K.2    Sasa, M.3    Izumi, R.4    Yajin, K.5    Harada, Y.6
  • 44
    • 0033781846 scopus 로고    scopus 로고
    • Effects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged run
    • A.E. Knitter, L. Panton, J.A. Rathmacher, A. Petersen, and R. Sharp Effects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged run J. Appl. Physiol. 89 2000 1340 1344
    • (2000) J. Appl. Physiol. , vol.89 , pp. 1340-1344
    • Knitter, A.E.1    Panton, L.2    Rathmacher, J.A.3    Petersen, A.4    Sharp, R.5
  • 45
    • 0034930037 scopus 로고    scopus 로고
    • Creatine and β-hydroxy-β-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program
    • DOI 10.1016/S0899-9007(01)00540-8, PII S0899900701005408
    • E. Jówko, P. Ostaszewski, M. Jank, J. Sacharuk, A. Zieniewicz, J. Wilczak, and S. Nissen Creatine and β-hydroxy-β-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program Nutrition 17 2001 558 566 (Pubitemid 32633785)
    • (2001) Nutrition , vol.17 , Issue.7-8 , pp. 558-566
    • Jowko, E.1    Ostaszewski, P.2    Jank, M.3    Sacharuk, J.4    Zieniewicz, A.5    Wilczak, J.6    Nissen, S.7
  • 48
    • 78649325141 scopus 로고    scopus 로고
    • Ecdysteroids from Chenopodium quinoa Willd., an ancient Andean crop of high nutritional value
    • S. Kumpun, A. Maria, S. Crouzet, N. Evrard-Todeschi, J.P. Girault, and R. Lafont Ecdysteroids from Chenopodium quinoa Willd., an ancient Andean crop of high nutritional value Food Chem. 125 2011 1226 1234
    • (2011) Food Chem. , vol.125 , pp. 1226-1234
    • Kumpun, S.1    Maria, A.2    Crouzet, S.3    Evrard-Todeschi, N.4    Girault, J.P.5    Lafont, R.6
  • 49
    • 85069925065 scopus 로고    scopus 로고
    • Ecdysteroid agonists and antagonists
    • L. Dinan, and R.E. Hormann Ecdysteroid agonists and antagonists L.I. Gilbert, K. Iatrou, S. Gill, Comprehensive Molecular Insect Science vol. 3 2005 Elsevier Oxford, UK 197 242
    • (2005) Comprehensive Molecular Insect Science , vol.3 , pp. 197-242
    • Dinan, L.1    Hormann, R.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.