메뉴 건너뛰기




Volumn 20, Issue 7, 2011, Pages 973-979

Targeted therapies in bone sarcomas: Current approach and future directions

Author keywords

bone sarcoma; molecular targets; review; targeted therapy

Indexed keywords

ANASTROZOLE; ANTINEOPLASTIC AGENT; DASATINIB; DROZITUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; EVEROLIMUS; EXEMESTANE; EZRIN; FIGITUMUMAB; GENE THERAPY AGENT; IMATINIB; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN; ONCOPROTEIN; ORANTINIB; PACLITAXEL; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; PROTEIN WT 1; R 1507; RAPAMYCIN; RAPAMYCIN DERIVATIVE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; REXIN G; RIDAFOROLIMUS; SOMATOMEDIN C; TRASTUZUMAB; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79958791448     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2011.577064     Document Type: Review
Times cited : (16)

References (52)
  • 2
    • 0042420638 scopus 로고    scopus 로고
    • Multiple primary malignancies in osteosarcoma patients. Incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma
    • DOI 10.1038/sj.ejhg.5201012
    • Hauben EI, Arends J, Vandenbroucke JP, et al. Multiple primary malignancies in osteosarcoma patients. Incidence and predictive value of osteosarcoma subtype for cancer syndromes related with osteosarcoma. Eur J Hum Genet 2003;11(8):611-18 (Pubitemid 37038776)
    • (2003) European Journal of Human Genetics , vol.11 , Issue.8 , pp. 611-618
    • Hauben, E.I.1    Arends, J.2    Vandenbroucke, J.P.3    Van Asperen, C.J.4    Van Marck, E.5    Hogendoorn, P.C.W.6
  • 3
    • 64749089013 scopus 로고    scopus 로고
    • Cause-specific mortality in long-term survivors of retinoblastoma
    • Yu CL, Tucker MA, Abramson DH, et al. Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst 2009;101(8):581-91
    • (2009) J Natl Cancer Inst , vol.101 , Issue.8 , pp. 581-91
    • Yu, C.L.1    Tucker, M.A.2    Abramson, D.H.3
  • 5
    • 63449118087 scopus 로고    scopus 로고
    • Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the surveillance, epidemiology, and end results program
    • Mirabello L, Troisi RJ, Savage SA. Osteosarcoma incidence and survival rates from 1973 to 2004: data from the surveillance, epidemiology, and end results program. Cancer 2009;115(7):1531-43
    • (2009) Cancer , vol.115 , Issue.7 , pp. 1531-43
    • Mirabello, L.1    Troisi, R.J.2    Savage, S.A.3
  • 6
    • 0022634225 scopus 로고
    • Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 60 years
    • Huvos AG. Osteogenic sarcoma of bones and soft tissues in older persons. A clinicopathologic analysis of 117 patients older than 60 years. Cancer 1986;57(7):1442-9 (Pubitemid 16136770)
    • (1986) Cancer , vol.57 , Issue.7 , pp. 1442-1449
    • Huvos, A.G.1
  • 9
    • 50649112829 scopus 로고    scopus 로고
    • Osteosarcoma development and stem cell differentiation
    • Tang N, Song WX, Luo J, et al. Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res 2008;466(9):2114-30
    • (2008) Clin Orthop Relat Res , vol.466 , Issue.9 , pp. 2114-30
    • Tang, N.1    Song, W.X.2    Luo, J.3
  • 10
    • 0031043523 scopus 로고    scopus 로고
    • ERM (ezrin/radixin/moesin) family: From cytoskeleton to signal transduction
    • DOI 10.1016/S0955-0674(97)80154-8
    • Tsukita S, Yonemura S. ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. Curr Opin Cell Biol 1997;9(1):70-5 (Pubitemid 27065111)
    • (1997) Current Opinion in Cell Biology , vol.9 , Issue.1 , pp. 70-75
    • Tsukita, S.1    Yonemura, S.2    Tsukita, S.3
  • 11
    • 0035033404 scopus 로고    scopus 로고
    • Current treatment of osteosarcoma
    • Ferguson W, Goorin AM. Current treatment of osteosarcoma. Cancer Invest 2001;19(3):23
    • (2001) Cancer Invest , vol.19 , Issue.3 , pp. 23
    • Ferguson, W.1    Goorin, A.M.2
  • 12
    • 33747358308 scopus 로고    scopus 로고
    • Bone tumours in European children and adolescents 1978-1997. Report from the Automated Childhood Cancer Information System Project
    • Stiller C, Bielack SS, Jundt G, et al. Bone tumours in European children and adolescents, 1978-1997. Report from the Automated Childhood Cancer Information System Project. Eur J Cancer 2006;42(13):11
    • (2006) Eur J Cancer , vol.42 , Issue.13 , pp. 11
    • Stiller, C.1    Bielack, S.S.2    Jundt, G.3
  • 13
    • 0019857472 scopus 로고
    • Contrasting epidemiology of childhood osteosarcoma, Ewing's tumor, and rhabdomyosarcoma
    • Miller R. Contrast epidemiology of childhood osteosarcoma, Ewing's tumor and rhabdomyosarcoma. Natl Cancer Inst Monogr 1981;(56):9-15 (Pubitemid 12193839)
    • (1981) National Cancer Institute Monograph , vol.56 , pp. 9-15
    • Miller, R.W.1
  • 14
    • 0033989280 scopus 로고    scopus 로고
    • Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family
    • de Alava E, Gerald WL. Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family. J Clin Oncol 2000;18(1):204-13 (Pubitemid 30036354)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.1 , pp. 204-213
    • De Alava, E.1    Gerald, W.L.2
  • 16
    • 3543026281 scopus 로고    scopus 로고
    • EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3
    • DOI 10.1128/MCB.24.16.7275-7283.2004
    • Prieur A, Tirode F, Cohen P, Delattre O. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol 2004;24(16):7275-83 (Pubitemid 39014452)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.16 , pp. 7275-7283
    • Prieur, A.1    Tirode, F.2    Cohen, P.3    Delattre, O.4
  • 17
    • 49949085240 scopus 로고    scopus 로고
    • IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells
    • Cironi L, Riggi N, Provero P, et al. IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells. PLoS One 2008;3(7):e2634
    • (2008) PLoS One , vol.3 , Issue.7
    • Cironi, L.1    Riggi, N.2    Provero, P.3
  • 18
    • 33750570283 scopus 로고    scopus 로고
    • Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells
    • DOI 10.1158/0008-5472.CAN-06-0927
    • Tirado OM, Mateo-Lozano S, Villar J, et al. Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells. Cancer Res 2006;66(20):9937-47 (Pubitemid 44672046)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 9937-9947
    • Tirado, O.M.1    Mateo-Lozano, S.2    Villar, J.3    Dettin, L.E.4    Llort, A.5    Gallego, S.6    Ban, J.7    Kovar, H.8    Notario, V.9
  • 19
    • 33845344030 scopus 로고    scopus 로고
    • NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma
    • DOI 10.1158/1541-7786.MCR-06-0090
    • Kinsey M, Smith R, Lessnick SL. NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma. Mol Cancer Res 2006;4(11):851-9 (Pubitemid 44877015)
    • (2006) Molecular Cancer Research , vol.4 , Issue.11 , pp. 851-859
    • Kinsey, M.1    Smith, R.2    Lessnick, S.L.3
  • 20
    • 33646366123 scopus 로고    scopus 로고
    • Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma
    • DOI 10.1016/j.ccr.2006.04.004, PII S1535610806001140
    • Smith R, Owen LA, Trem DJ, et al. Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma. Cancer Cell 2006;9(5):405-16 (Pubitemid 43668735)
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 405-416
    • Smith, R.1    Owen, L.A.2    Trem, D.J.3    Wong, J.S.4    Whangbo, J.S.5    Golub, T.R.6    Lessnick, S.L.7
  • 21
    • 70450184674 scopus 로고    scopus 로고
    • GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance
    • Luo W, Gangwal K, Sankar S, et al. GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance. Oncogene 2009;28(46):4126-32
    • (2009) Oncogene , vol.28 , Issue.46 , pp. 4126-32
    • Luo, W.1    Gangwal, K.2    Sankar, S.3
  • 22
    • 10744231438 scopus 로고    scopus 로고
    • EWS/ETS fusions activate telomerase in Ewing's tumor
    • Takahashi A, Higashino F, Aoyogi M, et al. EWS/ETS fusions activate telomerase in Ewing's tumor. Cancer Res 2003;63(23):6
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 6
    • Takahashi, A.1    Higashino, F.2    Aoyogi, M.3
  • 23
    • 58149301551 scopus 로고    scopus 로고
    • Chordoma and chondrosarcoma gene profile: Implications for immunotherapy
    • Schwab JH, Boland PJ, Agaram NP, et al. Chordoma and chondrosarcoma gene profile: implications for immunotherapy. Cancer Immunol Immunother 2009;58(3):339-49
    • (2009) Cancer Immunol Immunother , vol.58 , Issue.3 , pp. 339-49
    • Schwab, J.H.1    Boland, P.J.2    Agaram, N.P.3
  • 24
    • 33645231467 scopus 로고    scopus 로고
    • PDGFRalpha, PDGFRbeta and KIT expression/activation in conventional chondrosarcoma
    • Lagonigro MS, Tamborini E, Negri T, et al. PDGFRalpha, PDGFRbeta and KIT expression/activation in conventional chondrosarcoma. J Pathol 2006;208(5):615-23
    • (2006) J Pathol , vol.208 , Issue.5 , pp. 615-23
    • Lagonigro, M.S.1    Tamborini, E.2    Negri, T.3
  • 25
    • 37549046081 scopus 로고    scopus 로고
    • Immunohistochemical expression of estrogen receptors in chondrosarcomas and enchondromas
    • Grifone TJ, Haupt HM, Podolski V, Brooks JJ. Immunohistochemical expression of estrogen receptors in chondrosarcomas and enchondromas. Int J Surg Pathol 2008;16(1):31-7
    • (2008) Int J Surg Pathol , vol.16 , Issue.1 , pp. 31-7
    • Grifone, T.J.1    Haupt, H.M.2    Podolski, V.3    Brooks, J.J.4
  • 26
    • 28144449722 scopus 로고    scopus 로고
    • Estrogen signaling is active in cartilaginous tumors: Implications for antiestrogen therapy as treatment option of metastasized or irresectable chondrosarcoma
    • DOI 10.1158/1078-0432.CCR-05-1253
    • Cleton-Jansen AM, van Beerendonk HM, Baelde HJ, et al. Estrogen signaling is active in cartilaginous tumors: implications for antiestrogen therapy as treatment option of metastasized or irresectable chondrosarcoma. Clin Cancer Res 2005;11(22):8028-35 (Pubitemid 41698744)
    • (2005) Clinical Cancer Research , vol.11 , Issue.22 , pp. 8028-8035
    • Cleton-Jansen, A.-M.1    Van Beerendonk, H.M.2    Baelde, H.J.3    Bovee, J.V.G.M.4    Karperien, M.5    Hogendoorn, P.C.W.6
  • 28
    • 84873097110 scopus 로고    scopus 로고
    • Aromatase inhibition in patients with recurrent and/or metastatic chondrosarcoma. 2008 ASCO Annual Meeting Proceedings
    • Gelderblom H, Hohenberger J, Bovee JV, et al. Aromatase inhibition in patients with recurrent and/or metastatic chondrosarcoma. 2008 ASCO Annual Meeting Proceedings. J Clin Oncol 2008;26:10542
    • (2008) J Clin Oncol , vol.26 , pp. 10542
    • Gelderblom, H.1    Hohenberger, J.2    Bovee, J.V.3
  • 29
    • 77954302007 scopus 로고    scopus 로고
    • Imatinib (Gleevec) as a paradigm of targeted cancer therapies
    • Druker B. Imatinib (Gleevec) as a paradigm of targeted cancer therapies. Keio J Med 2010;59(1):1-3
    • (2010) Keio J Med , vol.59 , Issue.1 , pp. 1-3
    • Druker, B.1
  • 30
    • 79551701930 scopus 로고    scopus 로고
    • A phase 2 trial of imatinib mesylate in patients with recurrent nonresectable chondrosarcomas expressing platelet-derived growth factor receptor-alpha or-beta: An Italian Sarcoma Group study
    • Grignani G, Palmerini E, Stacchiotti S, et al. A phase 2 trial of imatinib mesylate in patients with recurrent nonresectable chondrosarcomas expressing platelet-derived growth factor receptor-alpha or-beta: an Italian Sarcoma Group study. Cancer 2011;117(4):826-31
    • (2011) Cancer , vol.117 , Issue.4 , pp. 826-31
    • Grignani, G.1    Palmerini, E.2    Stacchiotti, S.3
  • 31
    • 77950547753 scopus 로고    scopus 로고
    • Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors
    • Chao J, Budd GT, Chu P, et al. Phase II clinical trial of imatinib mesylate in therapy of KIT and/or PDGFRalpha-expressing Ewing sarcoma family of tumors and desmoplastic small round cell tumors. Anticancer Res 2010;30(2):547-52
    • (2010) Anticancer Res , vol.30 , Issue.2 , pp. 547-52
    • Chao, J.1    Budd, G.T.2    Chu, P.3
  • 32
    • 33947612000 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo
    • Klenke FM, Abdollahi A, Bertl E, et al. Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo. BMC Cancer 2007;7:49
    • (2007) BMC Cancer , vol.7 , pp. 49
    • Klenke, F.M.1    Abdollahi, A.2    Bertl, E.3
  • 33
    • 68049148657 scopus 로고    scopus 로고
    • Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment
    • Schrage YM, Briaire-de Bruijn IH, de Miranda NF, et al. Kinome profiling of chondrosarcoma reveals SRC-pathway activity and dasatinib as option for treatment. Cancer Res 2009;69(15):6216-22
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6216-22
    • Schrage, Y.M.1    Briaire-De Bruijn, I.H.2    De Miranda, N.F.3
  • 36
    • 0030598885 scopus 로고    scopus 로고
    • A signaling pathway to translational control
    • DOI 10.1016/S0092-8674(00)80125-7
    • Brown EJ, Schreiber SL. A signaling pathway to translational control. Cell 1996;86(4):517-20 (Pubitemid 26299483)
    • (1996) Cell , vol.86 , Issue.4 , pp. 517-520
    • Brown, E.J.1    Schreiber, S.L.2
  • 37
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • DOI 10.1158/0008-5472.CAN-04-3135
    • Wan X, Mendoza A, Khanna C, Helman LJ. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 2005;65(6):2406-11 (Pubitemid 40490152)
    • (2005) Cancer Research , vol.65 , Issue.6 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 38
    • 37149033966 scopus 로고    scopus 로고
    • Survival results with AP23573, a novel mTOR inhibitor, in patients with advanced soft tissue or bone sarcoma: Update of phase II trial. 2007 ASCO Annual Meeting Proceedings
    • Chawla S, Tolcher AW, Staddon AP, et al. Survival results with AP23573, a novel mTOR inhibitor, in patients with advanced soft tissue or bone sarcoma: update of phase II trial. 2007 ASCO Annual Meeting Proceedings. J Clin Oncol 2007;25(18s):10076
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 10076
    • Chawla, S.1    Tolcher, A.W.2    Staddon, A.P.3
  • 39
    • 0028332784 scopus 로고
    • Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth
    • Kappel CC, Velez-Yanguas MC, Hirschfeld S, Helman LJ. Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth. Cancer Res 1994;54(10):2803-7 (Pubitemid 24173778)
    • (1994) Cancer Research , vol.54 , Issue.10 , pp. 2803-2807
    • Kappel, C.C.1    Velez-Yanguas, M.C.2    Hirschfeld, S.3    Helman, L.J.4
  • 40
    • 75249097799 scopus 로고    scopus 로고
    • Safety pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: A phase 1 expansion cohort study
    • Olmos D, Postel-Vinay S, Molife LR, et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol 2010;11(2):129-35
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 129-35
    • Olmos, D.1    Postel-Vinay, S.2    Molife, L.R.3
  • 41
    • 78649438066 scopus 로고    scopus 로고
    • Activity of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor in patients with recurrent or refractory Ewing's sarcoma family of tumors: Results of a phase II SARC study. 2010 ASCO Annual Meeting Proceedings
    • Pappo A, Patel S, Crowley J, et al. Activity of R1507, a monoclonal antibody to the insulin-like growth factor-1 receptor in patients with recurrent or refractory Ewing's sarcoma family of tumors: results of a phase II SARC study. 2010 ASCO Annual Meeting Proceedings. J Clin Oncol 2010;25(15s):10000
    • (2010) J Clin Oncol , vol.25 , Issue.15 S , pp. 10000
    • Pappo, A.1    Patel, S.2    Crowley, J.3
  • 42
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang F, Greer A, Hurlburt W, et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res 2009;69(1):161-70
    • (2009) Cancer Res , vol.69 , Issue.1 , pp. 161-70
    • Huang, F.1    Greer, A.2    Hurlburt, W.3
  • 43
    • 20444501794 scopus 로고    scopus 로고
    • Prognostic and therapeutic relevance of Her2 expression in osteosarcoma and Ewing's sarcoma
    • Scotlandi K, Manara MC, Hattinger CM, et al. Prognostic and therapeutic relevance of Her2 expression in osteosarcoma and Ewing's sarcoma. Eur J Cancer 2005;41(9):12
    • (2005) Eur J Cancer , vol.41 , Issue.9 , pp. 12
    • Scotlandi, K.1    Manara, M.C.2    Hattinger, C.M.3
  • 44
    • 84873100252 scopus 로고    scopus 로고
    • Tumor immunotherapy targeting WT1 (Wilms' tumor gene) peptide for bone and soft-tissue sarcomas: A preliminary report. 2007 ASCO Annual Meeting Proceedings
    • Ueda TK, Kakunaga S, Oka Y, et al. Tumor immunotherapy targeting WT1 (Wilms' tumor gene) peptide for bone and soft-tissue sarcomas: a preliminary report. 2007 ASCO Annual Meeting Proceedings. J Clin Oncol 2007;25(18S):10042
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 10042
    • Ueda, T.K.1    Kakunaga, S.2    Oka, Y.3
  • 45
    • 1942453293 scopus 로고    scopus 로고
    • Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcoma
    • Anninga JK, van de Vijver MJ, Cleton-Jansen AM, et al. Overexpression of the HER-2 oncogene does not play a role in high-grade osteosarcoma. Eur J Cancer 2004;40(7):2
    • (2004) Eur J Cancer , vol.40 , Issue.7 , pp. 2
    • Anninga, J.K.1    Van De Vijver, M.J.2    Cleton-Jansen, A.M.3
  • 46
    • 16344386750 scopus 로고    scopus 로고
    • Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo
    • Guan H, Jia SF, Zhou Z, et al. Herceptin down-regulates HER-2/neu and vascular endothelial growth factor expression and enhances taxol-induced cytotoxicity of human Ewing's sarcoma cells in vitro and in vivo. Clin Cancer Res 2005;1(11):11
    • (2005) Clin Cancer Res , vol.1 , Issue.11 , pp. 11
    • Guan, H.1    Jia, S.F.2    Zhou, Z.3
  • 47
    • 84873090463 scopus 로고    scopus 로고
    • Tumor immunotherapy targeting WT1 (Wilms' tumor gene) peptide for bone and soft-tissue sarcomas: A preliminary report
    • Ueda T, Kakunaga S, Oka Y, et al. Tumor immunotherapy targeting WT1 (Wilms' tumor gene) peptide for bone and soft-tissue sarcomas: a preliminary report. Paper presented at: ASCO Annual Meeting Proceedings 2007
    • (2007) Paper Presented At: ASCO Annual Meeting Proceedings
    • Ueda, T.1    Kakunaga, S.2    Oka, Y.3
  • 48
    • 77956414973 scopus 로고    scopus 로고
    • Phase i dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
    • Herbst RS, Eckhardt SG, Kurzrock R, et al. Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol 2010;28(17):2839-46
    • (2010) J Clin Oncol , vol.28 , Issue.17 , pp. 2839-46
    • Herbst, R.S.1    Eckhardt, S.G.2    Kurzrock, R.3
  • 49
    • 69949145988 scopus 로고    scopus 로고
    • Phase I/II and phase II studies of targeted gene delivery in vivo: Intravenous Rexin-G for chemotherapy-resistant sarcoma and osteosarcoma
    • Chawla SP, Chua VS, Fernandez L, et al. Phase I/II and phase II studies of targeted gene delivery in vivo: intravenous Rexin-G for chemotherapy- resistant sarcoma and osteosarcoma. Mol Ther 2009;17(9):1651-7
    • (2009) Mol Ther , vol.17 , Issue.9 , pp. 1651-7
    • Chawla, S.P.1    Chua, V.S.2    Fernandez, L.3
  • 50
    • 24344444472 scopus 로고    scopus 로고
    • Phenotypic and molecular studies of giant cell tumor of bone and soft tissue
    • Lau Y, Sabokbar A, Gibbons CL. Phenotypic and molecular studies of giant cell tumor of bone and soft tissue. Hum Pathol 2005;36(9):9
    • (2005) Hum Pathol , vol.36 , Issue.9 , pp. 9
    • Lau, Y.1    Sabokbar, A.2    Gibbons, C.L.3
  • 51
    • 84873091337 scopus 로고    scopus 로고
    • Denosumab for the treatment of giant cell tumor (GCT) of bone: Final results form a proof-of-concept phase II study
    • Thomas DM, Chawla S, Skubitz A, et al. Denosumab for the treatment of giant cell tumor (GCT) of bone: final results form a proof-of-concept phase II study. Paper presented at: 2009 ASCO Annual Metting 2009
    • (2009) Paper Presented At: 2009 ASCO Annual Metting
    • Thomas, D.M.1    Chawla, S.2    Skubitz, A.3
  • 52
    • 0029913782 scopus 로고    scopus 로고
    • Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities
    • Pisters PW, Leung DH, Woodruff J, et al. Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. J Clin Oncol 1996;14:10
    • (1996) J Clin Oncol , vol.14 , pp. 10
    • Pisters, P.W.1    Leung, D.H.2    Woodruff, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.