Adenylate cyclase and calmodulin-dependent kinase have opposite effects on osteoclastogenesis by regulating the PKA-NFATc1 pathway

Journal of Bone and Mineral Research

Volumn 26, Issue 6, 2011, Pages 1217-1229

  Yoon, Soo Hyun ^a   Ryu, Ji Yoon ^b   Lee, Youngkyun ^a   Lee, Zang Hee ^a   Kim, Hong Hee ^a,c  

^a Seoul National University   (South Korea)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c School of Dentistry   (South Korea)

Author keywords

ADENYLATE CYCLASE; CA2+ CALMODULIN DEPENDENT PROTEIN KINASE; OSTEOCLAST; PROTEIN KINASE A

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 3; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CATALYSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MACROPHAGE; MALE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ADENYLATE CYCLASE; ANIMALS; BONE RESORPTION; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL DIFFERENTIATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MICE; MODELS, BIOLOGICAL; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; OSTEOGENESIS; PHOSPHORYLATION; RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 79958787780     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.310     Document Type: Article

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