Correlation of delta-like ligand 4 (DLL4) with VEGF and HIF-1α expression in human glioma

Asian Pacific Journal of Cancer Prevention

Volumn 12, Issue 1, 2011, Pages 215-218

  Li, Zhiqiang ^a   Wang, Jiang ^a   Gong, Lingling ^a   Wen, Zhihua ^a   Xu, Chengshi ^a   Huang, Xiaodong ^a  

^a ZHONGNAN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Angiogenesis; Delta like ligand 4; Glioma; HIF 1 ; VEGF

Indexed keywords

EID: 79958741819     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Benedito R, Roca C, Sorensen I, et al (2009). The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell, 137, 1124-35.
2. Buchler P, Gazdhar A, Schubert M, et al (2005). The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg, 242, 791-800, discussion 800-791.
3. Chu SH, Yuan XH, Jiang PC, et al (2005). [The expression of hepatocyte growth factor and its receptor in brain astrocytomas]. Zhonghua Yi Xue Za Zhi, 85, 835-8.
4. Diez H, Fischer A, Winkler A, et al (2007). Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res, 313, 1-9.
5. Gesuete R, Storini C, Fantin A, et al (2009). Recombinant C1 inhibitor in brain ischemic injury. Ann Neurol, 66, 332-42.
6. Hainaud P, Contreres JO, Villemain A, et al (2006). The role of the vascular endothelial growth factor-Delta-like 4 ligand/ Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res, 66, 8501-10.
7. Hellstrom M, Phng LK, Hofmann JJ, et al (2007). Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature, 445, 776-80.
8. Jain RK, di Tomaso E, Duda DG, et al (2007). Angiogenesis in brain tumours. Nat Rev Neurosci, 8, 610-22.
9. Jensen RL (2009). Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target. J Neurooncol, 92, 317-35.
10. Jouanneau E (2008). Angiogenesis and gliomas: current issues and development of surrogate markers. Neurosurgery, 62, 31-50; discussion 50-32.
11. Jubb AM, Turley H, Moeller HC, et al (2009). Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer. Br J Cancer, 101, 1749-57.
12. Kang YJ, Digicaylioglu M, Russo R, et al (2010). Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders. Ann Neurol, 68, 342-52.
13. Liu ZJ, Shirakawa T, Li Y, et al (2003). Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol, 23, 14-25.
14. Li Z, Yuan X, Wu T (2005). Expression of VEGF, MMPs and its relation with vascular ultrastructure in primary and recurrent gliomas. Chin J Neuromed, 4, 994-7.
15. Louis DN, Ohgaki H, Wiestler OD, et al (2007). The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol, 114, 97-109.
16. Noguera-Troise I, Daly C, Papadopoulos NJ, et al (2006). Blockade of Dll4 inhibits tumour growth by promoting nonproductive angiogenesis. Nature, 444, 1032-7.
17. Patel NS, Dobbie MS, Rochester M, et al (2006). Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res, 12, 4836-44.
18. Patel NS, Li JL, Generali D, et al (2005). Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res, 65, 8690-7.
19. Ridgway J, Zhang G, Wu Y, et al (2006). Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature, 444, 1083-7.
20. Scehnet JS, Jiang W, Kumar SR, et al (2007). Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood, 109, 4753-60.
21. Shi W, Harris AL (2006). Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J Mammary Gland Biol Neoplasia, 11, 41-52.
22. Shutter JR, Scully S, Fan W, et al (2000). Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev, 14, 1313-8.
23. Thurston G, Kitajewski J (2008). VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer, 99, 1204-9.
24. Yamanaka R, Saya H (2009). Molecularly targeted therapies for glioma. Ann Neurol, 66, 717-29.
25. Yamanda S, Ebihara S, Asada M, et al (2009). Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade. Blood, 113, 3631-9.
26. Xu X-Z, Li Z-Q, Wen Z-H (2010). Glioma-conditioned medium blocks endothelial cells' apoptosis Induced by hypoxia and promotes its angiogenesis via up-regulation of u-PA/u-PAR. Chinese J Cancer Res, 22, 119-25.