Postgenomics, uncertain futures, and the familiarization of susceptibility genes

Social Science and Medicine

Volumn 72, Issue 11, 2011, Pages 1768-1775

  Chilibeck, Gillian ^a   Lock, Margaret ^a   Sehdev, Megha ^b  

^a MCGILL UNIVERSITY   (Canada)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4; APOLIPOPROTEIN E4 EPSILON; UNCLASSIFIED DRUG;

DISEASE PREVALENCE; DISEASE TRANSMISSION; EMPIRICAL ANALYSIS; GENETIC ANALYSIS; GENETIC STRUCTURE; GENOTYPE; KINSHIP; PREDICTION;

ALLELE; ALZHEIMER DISEASE; APOLIPOPROTEIN E GENE; ARTICLE; ATTITUDE TO ILLNESS; DEMENTIA; ENVIRONMENTAL FACTOR; FAMILY HISTORY; FAMILY RELATION; GENE; GENETIC INFORMATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; HETEROZYGOTE; HUMAN; INFORMATION; INHERITANCE; LIFESTYLE; RISK ASSESSMENT; RISK FACTOR; SELF EVALUATION;

ADULT; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CANADA; EMPIRICAL RESEARCH; FAMILY RELATIONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HUMANS; MALE; MIDDLE AGED; TRUTH DISCLOSURE; UNCERTAINTY; UNITED STATES;

CANADA; UNITED STATES;

EID: 79958739282     PISSN: 02779536     EISSN: 18735347     Source Type: Journal    
DOI: 10.1016/j.socscimed.2010.01.053     Document Type: Article

References (46)

1. Barad K. Meeting the universe halfway: Quantum physics and the entanglement of matter and meaning 2007, Duke University Press, Durham/London.
2. Bertram L., Tanzi R.E. Alzheimer's disease: one disorder, too many genes?. Human Molecular Genetics 2004, 13:R135-R141.
3. Bestard J. Kinship and the new genetics. The changing meaning of biogenetic substance. Social Anthropology 2004, 12(3):253-263.
4. Browner C.H., Preloran H.M. Neurogenetic diagnoses: The power of hope and the limits of today's medicine 2010, Routledge Taylor and Francis Group, London.
5. Carsten J. Introduction: cultures of relatedness. Cultures of relatedness: New approaches to the study of kinship 2000, Cambridge University Press, Cambridge. J. Carsten (Ed.).
6. Carsten J. After kinship 2004, Cambridge University Press, Cambridge.
7. Corbo R.M., Scacchi R. Apolipoprotein E (APOE) allele distribution in the world: is APOE*4 a 'thrifty' allele?. Annals of Human Genetics 1999, 63:301-310.
8. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993, 261(5123):921-923.
9. Cox S., McKellin W. 'There's this thing in our family': predictive testing and the construction of risk for huntington disease. Sociological perspectives on the new genetics 1999, 121-148. Blackwell Publishers, London. P. Conrad, J. Gabe (Eds.).
10. Duden B., Samerski S. " Pop genes" an investigation of " the gene" in popular parlance. Biomedicine as culture: Instrumental practices, technoscientific knowledge, and new modes of life 2007, 167-190. Routledge, New York. R.V. Burri, J. Dumit (Eds.).
11. Emslie C., Hunt K., Watt G. A chip off the old block? Lay understandings of inheritance among men and women in mid-life. Public Understanding of Science 2003, 12(1):47.
12. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer's disease: a meta-analysis. Journal of the American Medical Association 1997, 278:1349-1356.
13. Featherstone K., Atkinson P., Bharadwaj A., Clarke A. Risky relations: Family, kinship and the new genetics 2006, Berg Publishers, New York.
14. Finkler K. Family, kinship, memory and temporality in the age of the new genetics. Social Science & Medicine 2005, 61(5):1059-1071.
15. Franklin S. Embodied progress: A cultural account of assisted conception 1997, Routledge, London.
16. Franklin S. Re-thinking nature-culture: anthropology of the new genetics. Anthropological Theory 2003, 3(65):65-85.
17. Franklin S., McKinnon S. Introduction. Relative values: Reconfiguring kinship studies 2001, 1-28. Duke University Press, Durham/London. S. Franklin, S. McKinnon (Eds.).
18. Franklin S., Ragone H. Reproducing reproduction: Kinship, power, and technological innovation 1998, University of Pennsylvania Press, Philadelphia.
19. Franklin S., Roberts C. Born and made: An ethnography of preimplantation genetic diagnosis 2006, Princeton University Press, Princeton.
20. Green J., Richards M., Murton F., Statham H., Hallowell N. Family communication and genetic counseling: the case of hereditary breast and ovarian cancer. Journal of Genetic Counseling 1997, 6(1):45-60.
21. Hallowell N. Doing the right thing: genetic risk and responsibility. Sociological perspectives on the new genetics 1999, 97-120. Blackwell Publishers, Oxford. P. Conrad, J. Gabe (Eds.).
22. Haraway D. A cyborg manifesto: science, technology, and socialist-feminism in the late twentieth century. Simians, cyborgs, and women: The reinvention of nature 1991, 149-181. Routledge, New York.
23. Harold D., Hollingworth P., Hamshere M., Holmans P., Abraham R., Sims R., et al. Genome-wide association study of age at onset of Alzheimer's disease. Alzheimer's and Dementia 2009, 5(4):471.
24. Howell S. Self-conscious kinship: some contested values in Norwegian transnational adoption. Relative values: Reconfiguring kinship studies 2001, 203-223. Duke University Press, Durham/London. S. Franklin, S. McKinnon (Eds.).
25. Hyman B.T., Gomez-Isla T., Briggs M., Chung H., Nichols S., Kohout F., et al. Apolipoprotein E and cognitive change in an elderly population. Annals of Neurology 1996, 40(1):55-66.
26. Jablonka E., Lamb M.J. Evolution in four dimensions: Genetic, epigenetic, behavioral, and symbolic variation in the history of life 2005, MIT Press, Cambridge, Mass.
27. Kerr A., Cunningham-Burley S., Amos A. The new genetics and health: mobilizing lay expertise. Public Understanding of Science 1998, 7(1):41.
28. Konrad M. Narrating the new predictive genetics: Ethics, ethnography and science 2005, Cambridge University Press, Cambridge.
29. Latour B. We have never been modern 1993, Harvard University Press, Cambridge, Mass.
30. Lock M. Eclipse of the gene and the return of divination. Current Anthropology 2005, 46(5):S47-S70.
31. Lock M. Biosociality and susceptibility genes. Biosocialities, genetics and the social sciences: Making biologies and identities 2008, 56-78. Routledge, New York. S. Gibbon, C. Novas (Eds.).
32. Lock, M. Dementia Entanglements in a Postgenomic Era. Science, Technology and Human Values, in press.
33. Lock M., Freeman J., Chilibeck G., Beveridge B., Padolsky M. Susceptibility genes and the question of embodied identity. Medical Anthropology Quarterly 2007, 21(3):256-276.
34. Lock M., Freeman J., Sharples R., Lloyd S. When it runs in the family: putting susceptibility genes in perspective. Public Understanding of Science 2006, 15(3):277.
35. Lock M., Lloyd S., Prest J. Genetic susceptibility and Alzheimer's disease: " the penetrance" and uptake of genetic knowledge. Thinking about dementia: Culture, loss, and the anthropology of senility 2006, 123-156. Rutgers, New Jersey. A. Leibing, L. Cohen (Eds.).
36. Lock M., Nguyen V.-K. An anthropology of biomedicine 2010, Wiley-Blackwell, New York.
37. Myers R.H., Schaefer E.J., Wilson P.W., D'Agostino R., Ordovas J.M., Espino A., et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: the framingham study. Neurology 1996, 46(3):673-677.
38. Oyama S., Griffiths P.E., Gray R.D. Cycles of contingency: Developmental systems and evolution 2001, MIT Press, Cambridge, Mass.
39. Richards M. Lay and professional knowledge of genetics and inheritance. Public Understanding of Science 1996, 5(3):217.
40. Roberts J.S., Cupples L.A., Relkin N.R., Whitehouse P.J., Green R.C. Genetic risk assessment for adult children of people with Alzheimer's disease: the risk evaluation and education for AD (REVEAL) study. Journal of Geriatric Psychiatry & Neurology 2005, 18:250-255.
41. Schneider D.M. American kinship: A cultural account 1968, Prentice-Hall, Englewood Cliffs, N.J.
42. Strathern M. No nature, no culture: the hagen case. Nature, culture and gender 1980, 174-222. Cambridge University Press, Cambridge. C. MacCormack, M. Strathern (Eds.).
43. Strathern M. Reproducing the future: Anthropology, kinship and the new reproductive technologies 1992, Routledge, New York.
44. Thompson C. Strategic naturalizing: kinship in an infertility clinic. Relative values: Reconfiguring kinship studies 2001, 175-202. Duke University Press, Durham and London. S. Franklin, S. McKinnon (Eds.).
45. Thompson C. Making parents: The ontological choreography of reproductive technologies 2005, MIT Press, Cambridge, MA.
46. Tilley L., Morgan K., Kalsheker N. Genetic risk factors in Alzheimer's disease. Journal of Clinical Pathology: Molecular Pathology 1998, 51:293-304.