Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men

Pain

Volumn 152, Issue 7, 2011, Pages 1495-1501

  Tajar, Abdelouahid ^a   McBeth, John ^a   Lee, David M ^a   MacFarlane, Gary J ^b   Huhtaniemi, Ilpo T ^c   Finn, Joseph D ^a   Bartfai, Gyorgy ^d   Boonen, Steven ^e   Casanueva, Felipe F ^f   Forti, Gianni ^g   Giwercman, Aleksander ^h   Han, Thang S ⁱ   Kula, Krzysztof ^j   Labrie, Fernand ^k   Lean, Michael E J ^l   Pendleton, Neil ^a   Punab, Margus ^m   Silman, Alan J ⁿ   Vanderschueren, Dirk ^e   O'Neill, Terence W ^a   Wu, Frederick C W ^a   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF SZEGED   (Hungary)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^g UNIVERSITY OF FLORENCE   (Italy)

^h LUND UNIVERSITY   (Sweden)

ⁱ UNIVERSITY COLLEGE LONDON   (United Kingdom)

^j MEDICAL UNIVERSITY OF LODZ   (Poland)

^k UNIVERSITÉ LAVAL   (Canada)

^l UNIVERSITY OF GLASGOW   (United Kingdom)

^m TARTU UNIVERSITY CLINICS   (Estonia)

ⁿ Arthritis Research UK   (United Kingdom)

more..

Author keywords

American College of Rheumatology; Epidemiology; European Male Ageing Study; Musculoskeletal pain; Reproductive hormones

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; SEX HORMONE; TESTOSTERONE;

ADULT; AGED; AGING; ARTICLE; CAUCASIAN; CHRONIC PAIN; ESTRADIOL BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MUSCULOSKELETAL PAIN; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL;

EID: 79958714448     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.01.048     Document Type: Article

References (32)

1. Akkus S, Delibas N, Tamer MN. Do sex hormones play a role in fibromyalgia? Rheumatology (Oxford) 2000;39:1161-3.
2. Apaja PM, Harju KT, Aatsinki JT, Petaja-Repo UE, Rajaniemi HJ. Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems. J Biol Chem 2004;279:1899-906. (Pubitemid 38084460)
3. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-71.
4. Bennett RM, Cook DM, Clark SR, Burckhardt CS, Campbell SM. Hypothalamic-pituitary-insulin-like growth factor-I axis dysfunction in patients with fibromyalgia. J Rheumatol 1997;24:1384-9. (Pubitemid 27353385)
5. Cairns BE, Gazerani P. Sex-related differences in pain. Maturitas 2009;63:292-6.
6. Dessein PH, Shipton EA, Joffe BI, Hadebe DP, Stanwix AE, Van der Merwe BA. Hyposecretion of adrenal androgens and the relation of serum adrenal steroids, serotonin and insulin-like growth factor-1 to clinical features in women with fibromyalgia. Pain 1999;83:313-9. (Pubitemid 29479291)
7. El Maghraoui A, Tellal S, Achemlal L, Nouijai A, Ghazi M, Mounach A, Bezza A, El Derouiche M. Bone turnover and hormonal perturbations in patients with fibromyalgia. Clin Exp Rheumatol 2006;24:428-31. (Pubitemid 44363545)
8. Finset A, Øverlie I, Holte A. Musculo-skeletal pain, psychological distress, and hormones during the menopausal transition. Psychoneuroendocrinology 2004;29:49-64.
9. Huisman AM, White KP, Algra A, Harth M, Vieth R, Jacobs JW, Bijlsma JW, Bell DA. Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. J Rheumatol 2001;28:2535-9. (Pubitemid 33031987)
10. Hunt IM, Silman AJ, Benjamin S, McBeth J, Macfarlane GJ. The prevalence and associated features of chronic widespread pain in the community using the 'Manchester' definition of chronic widespread pain. Rheumatology (Oxford) 1999;38:275-9.
11. Labrie F, Belanger A, Belanger P, Berube R, Martel C, Cusan L, Gomez J, Candas B, Castiel I, Chaussade V, Deloche C, Leclaire J. Androgen glucuronides, instead of testosterone, as the new markers of androgenic activity in women. J Steroid Biochem Mol Biol 2006;99:182-8. (Pubitemid 43766081)
12. Lee DM, O'Neill TW, Pye SR, Silman AJ, Finn JD, Pendleton N, Tajar A, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D, Wu FC. The European Male Ageing Study (EMAS): design, methods and recruitment. Int J Androl 2009;32:11-24.
13. LeResche L, Mancl LA, Drangsholt MT, Saunders K, Korff MV. Relationship of pain and symptoms to pubertal development in adolescents. Pain 2005;118:201-9.
14. Liu PY, Pincus SM, Takahashi PY, Roebuck PD, Iranmanesh A, Keenan DM, Veldhuis JD. Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade. Am J Physiol Endocrinol Metab 2006;290:E34-41.
15. Macfarlane TV, Blinkhorn A, Worthington HV, Davies RM, Macfarlane GJ. Sex hormonal factors and chronic widespread pain: a population study among women. Rheumatology (Oxford) 2002;41:454-7. (Pubitemid 34537846)
16. McBeth J, Macfarlane GJ, Benjamin S, Silman AJ. Features of somatization predict the onset of chronic widespread pain: results of a large populationbased study. Arthritis Rheum 2001;44:940-6. (Pubitemid 32319787)
17. McBeth J, Pye SR, O'Neill TW, Macfarlane GJ, Tajar A, Bartfai G, Boonen S, Bouillon R, Casanueva F, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Silman AJ, Vanderschueren D, Wu FC. Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study. Ann Rheum Dis 2010;69:1448-52.
18. McBeth J, Silman AJ, Gupta A, Chiu YH, Ray D, Morriss R, Dickens C, King Y, Macfarlane GJ. Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study. Arthritis Rheum 2007;56:360-71. (Pubitemid 46106210)
19. McBeth J, Tajar A, O'Neill TW, Macfarlane GJ, Pye SR, Bartfai G, Boonen S, Bouillon R, Casanueva F, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Pendleton N, Punab M, Silman AJ, Vanderschueren D, Wu FC. Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: results from the European Male Ageing Study. J Rheumatol 2009;36:2523-30.
20. Neeck G. Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients. Scand J Rheumatol Suppl 2000;113:8-12. (Pubitemid 32016429)
21. Okifuji A, Turk DC. Sex hormones and pain in regularly menstruating women with fibromyalgia syndrome. J Pain 2006;7:851-9. (Pubitemid 44636367)
22. Pednekar JR, Mulgaonker VK. Role of testosterone on pain threshold in rats. Indian J Physiol Pharmacol 1995;39:423-4.
23. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc 2003;78:1463-70. (Pubitemid 37475629)
24. Reuben DB, Siu AL. An objective measure of physical function of elderly outpatients. The Physical Performance Test. J Am Geriatr Soc 1990;38:1105-12.
25. Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H. Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab 2007;92:405-13.
26. Tajar A, Forti G, O'Neill TW, Lee DM, Silman AJ, Finn JD, Bartfai G, Boonen S, Casanueva FF, Giwercman A, Han TS, Kula K, Labrie F, Lean ME, Pendleton N, Punab M, Vanderschueren D, Huhtaniemi IT, Wu FC. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European Male Ageing Study. J Clin Endocrinol Metab 2010;95:1810-8.
27. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84:3666-72. (Pubitemid 30645223)
28. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morales A, Morley JE, Schulman C, Thompson IM, Weidner W, Wu FC, International Society of Andrology (ISA); International Society for the Study of Aging Male (ISSAM); European Association of Urology (EAU); European Academy of Andrology (EAA); American Society of Andrology (ASA). Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations. J Androl 2009;30:1-9.
29. White KP, Speechley M, Harth M, Ostbye T. Fibromyalgia in rheumatology practice: a survey of Canadian rheumatologists. J Rheumatol 1995;22:722-6.
30. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, Fam AG, Farber SJ, Fiechtner JJ, Franklin CM, Gatter RA, Hamaty D, Lessard J, Lichtbroun AS, Masi AT, McCain GA, Reynolds WJ, Romano TJ, Russell IJ, Sheon RP. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160-72.
31. Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Boonen S, Vanderschueren D, Labrie F, Huhtaniemi IT. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010;363:123-35.
32. Wu FC, Tajar A, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva F, Forti G, Giwercman A, Huhtaniemi IT, Kula K, Punab M, Boonen S, Vanderschueren D. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors. J Clin Endocrinol Metab 2008;93:2737-45. (Pubitemid 352008544)