-
2
-
-
0021054335
-
2 gene and its expression in Escherichia coli and Pseudomonas putida
-
2 gene and its expression in Escherichia coli and Pseudomonas putida. J. Bacteriol. 156, 1222-1227.
-
(1988)
J. Bacteriol.
, vol.156
, pp. 1222-1227
-
-
Minton, N.P.1
Atkinson, T.2
Sherwood, R.F.3
-
4
-
-
0002369919
-
Folate degrading enzymes: A review with special emphasis on carboxypeptidase G
-
J.S. Holcenberg and J. Roberts (Eds.), Wiley, New York
-
[4] Kalghatgi, K.K. and Bertino, J.R. (1981) Folate degrading enzymes: A review with special emphasis on carboxypeptidase G. In: J.S. Holcenberg and J. Roberts (Eds.), Enzymes as Drugs. Wiley, New York, pp. 77-102.
-
(1981)
Enzymes As Drugs
, pp. 77-102
-
-
Kalghatgi, K.K.1
Bertino, J.R.2
-
5
-
-
0022559902
-
2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro
-
2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro. Br. J. Cancer 53, 377-384.
-
(1986)
Br. J. Cancer
, vol.53
, pp. 377-384
-
-
Searle, F.1
Bier, C.2
Buckley, R.G.3
Newman, S.4
Pedley, R.B.5
Bagshawe, K.D.6
Melton, R.G.7
Alwan, S.M.8
Sherwood, R.F.9
-
7
-
-
0023619243
-
Antibody directed enzymes revive anti-cancer prodrugs concept
-
[7] Bagshawe, K.D. (1987) Antibody directed enzymes revive anti-cancer prodrugs concept. Br. J. Cancer 56, 531-532.
-
(1987)
Br. J. Cancer
, vol.56
, pp. 531-532
-
-
Bagshawe, K.D.1
-
8
-
-
0024246527
-
A cytotoxic agent can be generated selectively at cancer sites
-
[8] Bagshawe, K.D., Springer, C.J., Searle, F., Antoniw, P., Sharma, S.K., Melton, R.G. and Sherwood, R.F. (1988) A cytotoxic agent can be generated selectively at cancer sites. Br. J. Cancer 58, 700-703.
-
(1988)
Br. J. Cancer
, vol.58
, pp. 700-703
-
-
Bagshawe, K.D.1
Springer, C.J.2
Searle, F.3
Antoniw, P.4
Sharma, S.K.5
Melton, R.G.6
Sherwood, R.F.7
-
10
-
-
0025955579
-
Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds
-
[10] Springer, C.J., Bagshawe, K.D., Sharma, S.K., Searle, F., Boden, J.A., Antoniw, P., Burke, P.J., Rogers, G.T., Sherwood, R.F. and Melton, R.G. (1991) Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds. Eur. J. Cancer 27, 1361-1366.
-
(1991)
Eur. J. Cancer
, vol.27
, pp. 1361-1366
-
-
Springer, C.J.1
Bagshawe, K.D.2
Sharma, S.K.3
Searle, F.4
Boden, J.A.5
Antoniw, P.6
Burke, P.J.7
Rogers, G.T.8
Sherwood, R.F.9
Melton, R.G.10
-
11
-
-
0024722750
-
Towards generating cytotoxic agents at cancer sites
-
[11] Bagshawe, K.D. (1989) Towards generating cytotoxic agents at cancer sites. Br. J. Cancer 60, 275-281.
-
(1989)
Br. J. Cancer
, vol.60
, pp. 275-281
-
-
Bagshawe, K.D.1
-
12
-
-
0023798680
-
Preclinical studies and clinical correlation of the effect of alkylating dose
-
[12] Frei, E., Teicher, B.A., Holden, S.A., Cathcart, K.N.S. and Wang, Y. (1988) Preclinical studies and clinical correlation of the effect of alkylating dose. Cancer Res. 48, 6417-6423.
-
(1988)
Cancer Res.
, vol.48
, pp. 6417-6423
-
-
Frei, E.1
Teicher, B.A.2
Holden, S.A.3
Cathcart, K.N.S.4
Wang, Y.5
-
13
-
-
0011330677
-
A novel bisiodo-phenol mustard prodrug, ZD 2767P, for antibody directed enzyme prodrug therapy
-
[13] Davies, D.H., Blakey, D.C., Springer, C.J., Burke. P.J., Dowell, R.I., Boyle, F.T., Melton, R.G., Connors, T.A. and Mauger, A.B. (1995) A novel bisiodo-phenol mustard prodrug, ZD 2767P, for antibody directed enzyme prodrug therapy. Proc. Am. Assoc. Cancer Res. 36, 482.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 482
-
-
Davies, D.H.1
Blakey, D.C.2
Springer, C.J.3
Burke, P.J.4
Dowell, R.I.5
Boyle, F.T.6
Melton, R.G.7
Connors, T.A.8
Mauger, A.B.9
-
15
-
-
0027538834
-
2 conjugate in combination with a benzoic acid mustard prodrug
-
2 conjugate in combination with a benzoic acid mustard prodrug. Cell Biophys. 22, 1-8.
-
(1993)
Cell Biophys.
, vol.22
, pp. 1-8
-
-
Blakey, D.C.1
Valcaccia, B.E.2
East, S.3
Wright, A.F.4
Boyle, F.T.5
Springer, C.J.6
Burke, P.J.7
Melton, R.G.8
Bagshawe, K.D.9
-
16
-
-
0011322222
-
ZD2767: A new system for antibody-directed enzyme prodrug therapy which causes regressions in colorectal carcinoma xenografts
-
[16] Blakey, D.C., Sharma, S.K., Davies, D.H., Dowell, R.J., East. S.J., Springer, C.J. and Melton, R.G. (1995) ZD2767: A new system for antibody-directed enzyme prodrug therapy which causes regressions in colorectal carcinoma xenografts. Proc. Am. Assoc. Cancer Res. 36, 482.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 482
-
-
Blakey, D.C.1
Sharma, S.K.2
Davies, D.H.3
Dowell, R.J.4
East, S.J.5
Springer, C.J.6
Melton, R.G.7
-
18
-
-
0028014458
-
Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy
-
[18] Sharma, S.K., Bagshawe, K.D., Burke, P.J., Boden, J., Rogers, G.T., Springer, C.J., Melton, R.G. and Sherwood, R.F. (1994) Galactosylated antibodies and antibody-enzyme conjugates in Antibody-Directed Enzyme Prodrug Therapy. Cancer 73, 1114-1120.
-
(1994)
Cancer
, vol.73
, pp. 1114-1120
-
-
Sharma, S.K.1
Bagshawe, K.D.2
Burke, P.J.3
Boden, J.4
Rogers, G.T.5
Springer, C.J.6
Melton, R.G.7
Sherwood, R.F.8
-
19
-
-
0026900387
-
Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial
-
[19] Sharma, S.K., Bagshawe, K.D., Melton, R.G. and Sherwood, R.F. (1992) Human immune response to monoclonal antibody-enzyme conjugates in ADEPT pilot clinical trial. Cell Biophys. 21, 109-120.
-
(1992)
Cell Biophys.
, vol.21
, pp. 109-120
-
-
Sharma, S.K.1
Bagshawe, K.D.2
Melton, R.G.3
Sherwood, R.F.4
-
20
-
-
0028136892
-
Erwinia chrysanthemi asparaginase: Epitope mapping and preparation of antigenically modified enzymes
-
[20] Moola, Z., Scawen, M.D., Atkinson, T. and Nicholls, D.J. (1994) Erwinia chrysanthemi asparaginase: epitope mapping and preparation of antigenically modified enzymes. Biochem. J. 302, 921-927.
-
(1994)
Biochem. J.
, vol.302
, pp. 921-927
-
-
Moola, Z.1
Scawen, M.D.2
Atkinson, T.3
Nicholls, D.J.4
-
22
-
-
0024041278
-
Antitumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate
-
[22] Senter, P.D., Saulnier, M.G., Schreiber, G.J., Hirschberg, D.C., Brown, J.P., Hellstrom, I. and Hellstrom, K.E. (1988). Antitumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate. Proc. Natl. Acad. Sci. USA 85, 4842-4846.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 4842-4846
-
-
Senter, P.D.1
Saulnier, M.G.2
Schreiber, G.J.3
Hirschberg, D.C.4
Brown, J.P.5
Hellstrom, I.6
Hellstrom, K.E.7
-
23
-
-
0026577584
-
Analysis of a conjugate between anticarcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate
-
[23] Haisma, H.J., Boven, E., van Muijen, M., de Vries, R. and Pinedo, H.M. (1992). Analysis of a conjugate between anticarcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate. Cancer Immunol. Immunother., 34, 343-348.
-
(1992)
Cancer Immunol. Immunother.
, vol.34
, pp. 343-348
-
-
Haisma, H.J.1
Boven, E.2
Van Muijen, M.3
De Vries, R.4
Pinedo, H.M.5
-
24
-
-
0025648979
-
Second generation analogs of etoposide and mitomycin C
-
[24] Doyle, T.W. and Vyas, D.M. (1990) Second generation analogs of etoposide and mitomycin C. Cancer Treat. Rev. 17, 127-131.
-
(1990)
Cancer Treat. Rev.
, vol.17
, pp. 127-131
-
-
Doyle, T.W.1
Vyas, D.M.2
-
25
-
-
0024446208
-
Enhancement of the in vitro and in vivo antitumour activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates
-
[25] Senter, P.D., Schrieber, G.J., Hirschberg, D.L., Ashe, S.A., Hellstrom, K.E. and Hellstrom, I. (1989) Enhancement of the in vitro and in vivo antitumour activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates. Cancer Res. 49, 5789-5792.
-
(1989)
Cancer Res.
, vol.49
, pp. 5789-5792
-
-
Senter, P.D.1
Schrieber, G.J.2
Hirschberg, D.L.3
Ashe, S.A.4
Hellstrom, K.E.5
Hellstrom, I.6
-
26
-
-
0025186181
-
Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/ anti-alkaline phosphatase monoclonal antibody
-
[26] Sahin, U., Hartmann, F., Senter, P., Pohl, C., Engert, A., Diehl, V. and Pfreundschuh, M. (1990) Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/ anti-alkaline phosphatase monoclonal antibody. Cancer Res. 50, 6944-6948.
-
(1990)
Cancer Res.
, vol.50
, pp. 6944-6948
-
-
Sahin, U.1
Hartmann, F.2
Senter, P.3
Pohl, C.4
Engert, A.5
Diehl, V.6
Pfreundschuh, M.7
-
27
-
-
0025174052
-
Activation of prodrugs by antibody-enzyme conjugates: A new approach to cancer therapy
-
[27] Senter, P.D. (1990) Activation of prodrugs by antibody-enzyme conjugates: a new approach to cancer therapy. FASEB J. 4, 188-193.
-
(1990)
FASEB J.
, vol.4
, pp. 188-193
-
-
Senter, P.D.1
-
28
-
-
0026212613
-
In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate
-
[28] Wallace, P.M. and Senter, P.D. (1991) In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate. Bioconjugate Chem. 2, 349-352.
-
(1991)
Bioconjugate Chem.
, vol.2
, pp. 349-352
-
-
Wallace, P.M.1
Senter, P.D.2
-
29
-
-
0021880212
-
Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules
-
[29] Nishiyama, T., Kawamura, Y., Kawamoto, K., Matsumura, H., Ito, N., Ohyama, A., Katsuragi, T. and Sakai, T. (1985) Antineoplastic effects in rats of 5-fluorocytosine in combination with cytosine deaminase capsules. Cancer Res. 45, 1753-1761.
-
(1985)
Cancer Res.
, vol.45
, pp. 1753-1761
-
-
Nishiyama, T.1
Kawamura, Y.2
Kawamoto, K.3
Matsumura, H.4
Ito, N.5
Ohyama, A.6
Katsuragi, T.7
Sakai, T.8
-
30
-
-
0024201396
-
Overview: Rational basis for development of fluoropyrimidine/5-formyltetrahydrofolate combination chemotherapy
-
Y. Rustum and J.J. McGuire (Eds.), Plenum Press, New York
-
[30] Huennekens, F.M., Montejano, Y.D. and Vitols, K.S. (1988) Overview: Rational basis for development of fluoropyrimidine/5-formyltetrahydrofolate combination chemotherapy. In: Y. Rustum and J.J. McGuire (Eds.), The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology. Vol. 244. Plenum Press, New York, pp. 1-12.
-
(1988)
The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. Advances in Experimental Medicine and Biology
, vol.244
, pp. 1-12
-
-
Huennekens, F.M.1
Montejano, Y.D.2
Vitols, K.S.3
-
31
-
-
0027179163
-
Initial clinical experience with oral ftorafur and oral 6R. S leucovorin in advanced colorectal carcinoma
-
[31] Manzuik, L.V., Perevodchikova, N.I., Gorbunova, V.A., Singin, A.S., Gerasimova, G.S., Bychkov, M.B., Rustum, Y.M. and Creavan, P.J. (1993) Initial clinical experience with oral ftorafur and oral 6R. S leucovorin in advanced colorectal carcinoma. Eur. J. Cancer 29A, 1793-1794.
-
(1993)
Eur. J. Cancer
, vol.29 A
, pp. 1793-1794
-
-
Manzuik, L.V.1
Perevodchikova, N.I.2
Gorbunova, V.A.3
Singin, A.S.4
Gerasimova, G.S.5
Bychkov, M.B.6
Rustum, Y.M.7
Creavan, P.J.8
-
32
-
-
0026250463
-
Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugate
-
[32] Senter, P.D., Su, P.C., Katsuragi, T., Sakai, T., Cosand, W.L., Hellstrom. I. and Hellstrom, K.E. (1991) Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antibody-cytosine deaminase conjugate. Bioconjugate Chem. 2, 447-451.
-
(1991)
Bioconjugate Chem.
, vol.2
, pp. 447-451
-
-
Senter, P.D.1
Su, P.C.2
Katsuragi, T.3
Sakai, T.4
Cosand, W.L.5
Hellstrom, I.6
Hellstrom, K.E.7
-
33
-
-
0028335819
-
Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
-
[33] Wallace, P.M., MacMaster, J.F., Smith, V.F., Kerr, D.E., Senter, P.D. and Cosand, W.L. (1994) Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res. 54, 2719-2723.
-
(1994)
Cancer Res.
, vol.54
, pp. 2719-2723
-
-
Wallace, P.M.1
MacMaster, J.F.2
Smith, V.F.3
Kerr, D.E.4
Senter, P.D.5
Cosand, W.L.6
-
34
-
-
0027656118
-
Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of a cytosine deaminase conjugate
-
[34] Kerr, D.E., Garrigues, U.S., Wallace, P.M., Hellstrom, K.E., Hellstrom, I. and Senter, P.D. (1993) Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of a cytosine deaminase conjugate. Bioconjugate Chem. 4, 353-357.
-
(1993)
Bioconjugate Chem.
, vol.4
, pp. 353-357
-
-
Kerr, D.E.1
Garrigues, U.S.2
Wallace, P.M.3
Hellstrom, K.E.4
Hellstrom, I.5
Senter, P.D.6
-
35
-
-
0025864963
-
A novel targeted delivery system utilising a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer
-
[35] Shepherd, T.A., Jungheim, L.N., Meyer, D.L. and Starling, J.J. (1991) A novel targeted delivery system utilising a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancer. Biorg. Med. Chem. Lett. 1, 21-26.
-
(1991)
Biorg. Med. Chem. Lett.
, vol.1
, pp. 21-26
-
-
Shepherd, T.A.1
Jungheim, L.N.2
Meyer, D.L.3
Starling, J.J.4
-
36
-
-
0026562808
-
Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: Substrates for an antibody-targeted enzyme
-
[36] Jungheim, L.N., Shepherd, T.A. and Meyer. D.L. (1992) Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: Substrates for an antibody-targeted enzyme. J. Org. Chem. 57, 2334-2340.
-
(1992)
J. Org. Chem.
, vol.57
, pp. 2334-2340
-
-
Jungheim, L.N.1
Shepherd, T.A.2
Meyer, D.L.3
Chem, J.O.4
-
37
-
-
0026487592
-
Preparation and characterisation of a β-lactamase-fab′ conjugate for the site specific activation of oncolytic agents
-
[37] Meyer, D.L., Jungheim, L.N., Mikolajczyk, S.D., Shepherd, T.A., Starling, J.J. and Ahlem, C.N. (1992) Preparation and characterisation of a β-lactamase-Fab′ conjugate for the site specific activation of oncolytic agents. Bioconjugate Chem. 3, 42-48.
-
(1992)
Bioconjugate Chem.
, vol.3
, pp. 42-48
-
-
Meyer, D.L.1
Jungheim, L.N.2
Mikolajczyk, S.D.3
Shepherd, T.A.4
Starling, J.J.5
Ahlem, C.N.6
-
38
-
-
0027220125
-
Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
-
[38] Meyer, D.L., Jungheim, L.N., Law, K.L., Mikolajczyk, S.D., Shepherd, T.A., Mackenson, D.G., Briggs, S.L. and Starling, J.J. (1993) Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res. 53, 3956-3963.
-
(1993)
Cancer Res.
, vol.53
, pp. 3956-3963
-
-
Meyer, D.L.1
Jungheim, L.N.2
Law, K.L.3
Mikolajczyk, S.D.4
Shepherd, T.A.5
Mackenson, D.G.6
Briggs, S.L.7
Starling, J.J.8
-
39
-
-
0000814098
-
Synthesis of a cephalosporin-doxorubicin antitumour prodrug: A substrate for an antibody-targeted enzyme
-
[39] Jungheim, L.N., Shepherd, T.A. and King, J.K. (1993) Synthesis of a cephalosporin-doxorubicin antitumour prodrug: a substrate for an antibody-targeted enzyme, Heterocycles (Tokyo) 35, 329-348.
-
(1993)
Heterocycles (Tokyo)
, vol.35
, pp. 329-348
-
-
Jungheim, L.N.1
Shepherd, T.A.2
King, J.K.3
-
40
-
-
0027407548
-
Synthesis and release ol doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate
-
[40] Hudyma, T.W., Bush, K., Colson, K.L., Firestone, R.A. and King, H.D. (1993) Synthesis and release ol doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate. Biorg. Med. Chem. Lett. 3, 323-328.
-
(1993)
Biorg. Med. Chem. Lett.
, vol.3
, pp. 323-328
-
-
Hudyma, T.W.1
Bush, K.2
Colson, K.L.3
Firestone, R.A.4
King, H.D.5
-
41
-
-
0028091914
-
Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates
-
[41] Wallace, P.M. and Senter, P.D. (1994) Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates. Methods Find. Exp. Clin. Pharmacol. 16, 505-512.
-
(1994)
Methods Find. Exp. Clin. Pharmacol.
, vol.16
, pp. 505-512
-
-
Wallace, P.M.1
Senter, P.D.2
-
42
-
-
0028959129
-
HER2 Fv-β-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug
-
HER2 Fv-β-lactamase fusion protein for activation of a cephalosporin doxorubicin prodrug. Cancer Res. 55, 63-70.
-
(1995)
Cancer Res.
, vol.55
, pp. 63-70
-
-
Rodrigues, M.L.1
Presta, L.G.2
Kotts, C.E.3
Wirth, C.4
Mordenti, J.5
Osaka, G.6
Wong, W.-L.T.7
Nuijens, A.8
Blackburn, B.9
Carter, P.10
-
43
-
-
0028351101
-
A bi-functional murine::Human chimeric antibody with one antigen-binding arm replaced by bacterial β-lactamase
-
[43] De Sutter, K. and Fiers, W. (1994) A bi-functional murine::human chimeric antibody with one antigen-binding arm replaced by bacterial β-lactamase. Mol. Immunol. 31, 261-267.
-
(1994)
Mol. Immunol.
, vol.31
, pp. 261-267
-
-
De Sutter, K.1
Fiers, W.2
-
44
-
-
0025897111
-
Cephalosporin nitrogen mustard carbamate prodrugs for 'ADEPT'
-
[44] Alexander, R.P., Beeley, N.R.A., O'Driscol, M., O'Neill, F.P., Millican, T.A., Pratt, A.J. and Willenbrock, F.W. (1991) Cephalosporin nitrogen mustard carbamate prodrugs for 'ADEPT'. Tetrahedron Lett. 32, 3269-3272.
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 3269-3272
-
-
Alexander, R.P.1
Beeley, N.R.A.2
O'Driscol, M.3
Neill, F.P.4
Millican, T.A.5
Pratt, A.J.6
Willenbrock, F.W.7
-
45
-
-
0026826545
-
Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug
-
[45] Svensson, H.P., Kadow, J.F., Vrudhula, V.M., Wallace, P.M. and Senter, P.D. (1992) Monoclonal antibody-β-lactamase conjugates for the activation of a cephalosporin mustard prodrug. Bioconjugate Chem. 3, 176-181.
-
(1992)
Bioconjugate Chem.
, vol.3
, pp. 176-181
-
-
Svensson, H.P.1
Kadow, J.F.2
Vrudhula, V.M.3
Wallace, P.M.4
Senter, P.D.5
-
46
-
-
0027655158
-
Antitumour activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates
-
[46] Vrudhula, V.M., Svensson, H.P., Kennedy, K.A., Senter, P.D. and Wallace, P.M. (1993) Antitumour activities of a cephalosporin prodrug in combination with monoclonal antibody-β-lactamase conjugates. Bioconjugate Chem. 4, 334-340.
-
(1993)
Bioconjugate Chem.
, vol.4
, pp. 334-340
-
-
Vrudhula, V.M.1
Svensson, H.P.2
Kennedy, K.A.3
Senter, P.D.4
Wallace, P.M.5
-
47
-
-
0025352171
-
Antibody-penicillin-V-amidase conjugates kill antigen-positive tumour cells when combined with doxorubicin phenoxyacetamide
-
[47] Kerr, D.E., Senter, P.D., Burnett, W.V., Hirschberg, D.L., Hellstrom, I. and Hellstrom, K.E. (1990) Antibody-penicillin-V-amidase conjugates kill antigen-positive tumour cells when combined with doxorubicin phenoxyacetamide. Cancer Immunol. Immunother. 31, 202-206.
-
(1990)
Cancer Immunol. Immunother.
, vol.31
, pp. 202-206
-
-
Kerr, D.E.1
Senter, P.D.2
Burnett, W.V.3
Hirschberg, D.L.4
Hellstrom, I.5
Hellstrom, K.E.6
-
48
-
-
0027537670
-
Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin-G amidase conjugate
-
[48] Vrudhula, V.M., Senter, P.D., Fischer, K.J. and Wallace, P.M. (1993) Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin-G amidase conjugate. J. Med. Chem. 36, 919-923.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 919-923
-
-
Vrudhula, V.M.1
Senter, P.D.2
Fischer, K.J.3
Wallace, P.M.4
-
49
-
-
0026670255
-
N-(4′-hydroxylphenylacetyl)palytoxin. A palytoxin prodrug that can be activated by a monoclonal antibody-penicillin G amidase conjugate
-
[49] Bignami, G.S., Senter, P.D., Grothaus, P.G., Fischer, K.J., Humphreys, T. and Wallace, P.M. (1992). N-(4′-hydroxylphenylacetyl)palytoxin. A palytoxin prodrug that can be activated by a monoclonal antibody-penicillin G amidase conjugate. Cancer Res. 52, 5759-5764.
-
(1992)
Cancer Res.
, vol.52
, pp. 5759-5764
-
-
Bignami, G.S.1
Senter, P.D.2
Grothaus, P.G.3
Fischer, K.J.4
Humphreys, T.5
Wallace, P.M.6
-
51
-
-
0022978891
-
CB1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells
-
[51] Roberts, J.J., Friedlos, F. and Knox, R.J. (1986) CB1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells. Biochem. Biophys. Res. Commun. 140, 1073-1078.
-
(1986)
Biochem. Biophys. Res. Commun.
, vol.140
, pp. 1073-1078
-
-
Roberts, J.J.1
Friedlos, F.2
Knox, R.J.3
-
52
-
-
0024209370
-
A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2.-4-dinitrobenzamide (CB1954) by a nitroreductase enzyme in Walker carcinoma cells
-
[52] Knox, R.J., Friedlos, F., Jarman, M. and Roberts, J.J. (1988) A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2.-4-dinitrobenzamide (CB1954) by a nitroreductase enzyme in Walker carcinoma cells. Biochem. Pharmacol. 37, 4661-4669.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 4661-4669
-
-
Knox, R.J.1
Friedlos, F.2
Jarman, M.3
Roberts, J.J.4
-
53
-
-
0024205344
-
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)
-
[53] Knox, R.J., Boland, M.P., Friedlos, F., Coles, B., Southan, C. and Roberts, J.J. (1988) The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2). Biochem. Pharmacol. 37, 4671-4677.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 4671-4677
-
-
Knox, R.J.1
Boland, M.P.2
Friedlos, F.3
Coles, B.4
Southan, C.5
Roberts, J.J.6
-
54
-
-
0026745562
-
The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)-I. Purification and properties of a nitroreductase enzyme from Escherichia coli - A potential enzyme for antibody directed enzyme prodrug therapy (ADEPT)
-
[54] Anlezark, G.M., Melton, R.G., Sherwood, R.F., Coles, B., Friedlos, F. and Knox, R.J. (1992) The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)-I. Purification and properties of a nitroreductase enzyme from Escherichia coli - a potential enzyme for antibody directed enzyme prodrug therapy (ADEPT). Biochem. Pharmacol. 44, 2289-2295.
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 2289-2295
-
-
Anlezark, G.M.1
Melton, R.G.2
Sherwood, R.F.3
Coles, B.4
Friedlos, F.5
Knox, R.J.6
-
55
-
-
0026677838
-
The bioactivation of 5-(aziridin-1-yl)-2.4-dinitrobenzamide (CB1954)-II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase
-
[55] Knox, R.J., Friedlos, F., Sherwood, R.F., Melton, R.G. and Anlezark, G.M. (1992) The bioactivation of 5-(aziridin-1-yl)-2.4-dinitrobenzamide (CB1954)-II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase. Biochem. Pharmacol. 44, 2297-2301.
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 2297-2301
-
-
Knox, R.J.1
Friedlos, F.2
Sherwood, R.F.3
Melton, R.G.4
Anlezark, G.M.5
-
56
-
-
0027949306
-
Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12
-
[56] Michael, N.P., Brehm, J.K., Anlezark, G.M. and Minton, N.P. (1994) Physical characterisation of the Escherichia coli B gene encoding nitroreductase and its over-expression in Escherichia coli K12. FEMS Microbiol. Lett. 124, 195-202.
-
(1994)
FEMS Microbiol. Lett.
, vol.124
, pp. 195-202
-
-
Michael, N.P.1
Brehm, J.K.2
Anlezark, G.M.3
Minton, N.P.4
-
57
-
-
0026713627
-
Metabolism of NAD(P)H by blood components. Relevance to Bioreductively Activated Prodrugs in A Targeted Enzyme Therapy System
-
[57] Friedlos, F. and Knox, R.J. (1992) Metabolism of NAD(P)H by blood components. Relevance to bioreductively activated prodrugs in a targeted enzyme therapy system. Biochem. Pharmacol. 44, 631-635.
-
(1992)
Biochem. Pharmacol.
, vol.44
, pp. 631-635
-
-
Friedlos, F.1
Knox, R.J.2
-
58
-
-
0029009389
-
Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT)
-
[58] Knox, R.J., Friedlos, F., Jarman, M., Davies, L.C., Goddard, P., Anlezark, G.M., Melton, R.G. and Sherwood, R.F. (1995) Virtual cofactors for an Escherichia coli nitroreductase enzyme: Relevance to reductively activated prodrugs in antibody directed enzyme prodrug therapy (ADEPT). Biochem. Pharmacol. 49, 1641-1647.
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 1641-1647
-
-
Knox, R.J.1
Friedlos, F.2
Jarman, M.3
Davies, L.C.4
Goddard, P.5
Anlezark, G.M.6
Melton, R.G.7
Sherwood, R.F.8
-
59
-
-
0029147264
-
Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase
-
[59] Anlezark, G.M., Melton, R.G., Sherwood. R.F., Wilson, R.W., Denny, W.A., Palmer, B.D., Knox, R.J., Friedlos, F. and Williams, A. (1995) Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase. Biochem. Pharmacol. 50, 609-618.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 609-618
-
-
Anlezark, G.M.1
Melton, R.G.2
Sherwood, R.F.3
Wilson, R.W.4
Denny, W.A.5
Palmer, B.D.6
Knox, R.J.7
Friedlos, F.8
Williams, A.9
-
60
-
-
0011281953
-
Nitroreductase substrates as potential prodrugs for ADEPT
-
[60] Anlezark, G., Melton, R., Sherwood, R., Knox. R., Friedlos, F., Palmer, B., Wilson, W. and Denny, W. (1994) Nitroreductase substrates as potential prodrugs for ADEPT. Br. J. Cancer 69 Suppl. XXI, 57.
-
(1994)
Br. J. Cancer
, vol.69
, Issue.SUPPL. XXI
, pp. 57
-
-
Anlezark, G.1
Melton, R.2
Sherwood, R.3
Knox, R.4
Friedlos, F.5
Palmer, B.6
Wilson, W.7
Denny, W.8
-
61
-
-
0028090161
-
Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme
-
[61] Mauger, A.B., Burke, P.J., Somani, H.H., Friedlos, F. and Knox, R.J. (1994) Self-immolative prodrugs: Candidates for antibody-directed enzyme prodrug therapy in conjunction with a nitroreductase enzyme. J. Med. Chem. 37, 3452-3458.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 3452-3458
-
-
Mauger, A.B.1
Burke, P.J.2
Somani, H.H.3
Friedlos, F.4
Knox, R.J.5
-
62
-
-
0024583590
-
Carboxypeptidase-mediated release of methotrexate from methotrexate α-peptides
-
[62] Kuefner, U., Lohrmann, U., Montejano, Y.D., Vitols, K.S. and Huennekens, F.M. (1989) Carboxypeptidase-mediated release of methotrexate from methotrexate α-peptides. Biochemistry 28, 2288-2297.
-
(1989)
Biochemistry
, vol.28
, pp. 2288-2297
-
-
Kuefner, U.1
Lohrmann, U.2
Montejano, Y.D.3
Vitols, K.S.4
Huennekens, F.M.5
-
63
-
-
0025937458
-
Construction and chemotherapeutic potential of carboxypeptidase-A/monoclonal antibody conjugate
-
[63] Esswein, A., Hanseler, E., Montejano, Y., Vitols, K.S. and Huennekens, F.M. (1991) Construction and chemotherapeutic potential of carboxypeptidase-A/monoclonal antibody conjugate. Adv. Enzyme Regul. 31, 3-12.
-
(1991)
Adv. Enzyme Regul.
, vol.31
, pp. 3-12
-
-
Esswein, A.1
Hanseler, E.2
Montejano, Y.3
Vitols, K.S.4
Huennekens, F.M.5
-
64
-
-
0026536712
-
Activation of methotrexate-α-alanine by carboxypeptidase A-monoclonal antibody conjugate
-
[64] Haenseler, E., Esswein, A., Vitols, K.S., Montejano, Y., Mueller, B.M., Reisfeld, R.A. and Huennekens, F.M. (1992) Activation of methotrexate-α-alanine by carboxypeptidase A-monoclonal antibody conjugate. Biochemistry 31, 891-897.
-
(1992)
Biochemistry
, vol.31
, pp. 891-897
-
-
Haenseler, E.1
Esswein, A.2
Vitols, K.S.3
Montejano, Y.4
Mueller, B.M.5
Reisfeld, R.A.6
Huennekens, F.M.7
-
65
-
-
0027934667
-
Synthesis of methotrexate prodrugs as an approach for drug targeting
-
[65] Perron, M-J. and Page, M. (1994) Synthesis of methotrexate prodrugs as an approach for drug targeting. Int. J. Oncol. 5, 907-913.
-
(1994)
Int. J. Oncol.
, vol.5
, pp. 907-913
-
-
Perron, M.-J.1
Page, M.2
-
66
-
-
0028979473
-
Activation and cytotoxicity of 2-α aminoacyl prodrugs of methotrexate
-
[66] Smal, M.A., Dong, Z., Cheung, H.T.A., Asano, Y., Escoffier. L,. Costello, M. and Tattersall, M.H.N. (1995) Activation and cytotoxicity of 2-α aminoacyl prodrugs of methotrexate. Biochem. Pharmacol. 49, 567-574.
-
(1995)
Biochem. Pharmacol.
, vol.49
, pp. 567-574
-
-
Smal, M.A.1
Dong, Z.2
Cheung, H.T.A.3
Asano, Y.4
Escoffier, L.5
Costello, M.6
Tattersall, M.H.N.7
-
67
-
-
0014024073
-
Cure of mice bearing advanced plasma cell tumours with aniline mustard: The relationship between glucuronidase activity and tumour sensitivity
-
[67] Connors, T.A. and Whisson, M.E. (1966) Cure of mice bearing advanced plasma cell tumours with aniline mustard: The relationship between glucuronidase activity and tumour sensitivity. Nature 210, 866-867.
-
(1966)
Nature
, vol.210
, pp. 866-867
-
-
Connors, T.A.1
Whisson, M.E.2
-
68
-
-
0015621801
-
Evaluation of aniline mustard in patients with multiple myeloma
-
[68] Kyle, R.A., Costa, G., Cooper, M.R., Ogawa, M., Silver, R.T., Glidewell, O. and Holland, J.F. (1973) Evaluation of aniline mustard in patients with multiple myeloma. Crit. Rev. Biochem. Mol. Biol. 33, 956-960.
-
(1973)
Crit. Rev. Biochem. Mol. Biol.
, vol.33
, pp. 956-960
-
-
Kyle, R.A.1
Costa, G.2
Cooper, M.R.3
Ogawa, M.4
Silver, R.T.5
Glidewell, O.6
Holland, J.F.7
-
69
-
-
0025936081
-
Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate
-
[69] Roffler, S.R., Wang, S.M., Chern, J.W., Yeh, M.Y. and Tung, E. (1991) Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate. Biochem. Pharmacol. 42, 2062-2065.
-
(1991)
Biochem. Pharmacol.
, vol.42
, pp. 2062-2065
-
-
Roffler, S.R.1
Wang, S.M.2
Chern, J.W.3
Yeh, M.Y.4
Tung, E.5
-
70
-
-
0026794283
-
Specific activation of glucuronide prodrugs by antibody-targeted enzymes for cancer therapy
-
[70] Wang, S.M., Chern, J.W., Yeh, M.Y., Ng, Y.C., Tung, E. and Roffler, S.R. (1992) Specific activation of glucuronide prodrugs by antibody-targeted enzymes for cancer therapy. Cancer Res. 52, 4484-4491.
-
(1992)
Cancer Res.
, vol.52
, pp. 4484-4491
-
-
Wang, S.M.1
Chern, J.W.2
Yeh, M.Y.3
Ng, Y.C.4
Tung, E.5
Roffler, S.R.6
-
71
-
-
0026802983
-
A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer
-
[71] Haisma, H.J., Boven, E., van Muijen, M., de Jong, J., van der Vijgh, W.J.F. and Pinedo, H.M. (1992) A monoclonal antibody-β-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer. Br. J. Cancer 66, 474-478.
-
(1992)
Br. J. Cancer
, vol.66
, pp. 474-478
-
-
Haisma, H.J.1
Boven, E.2
Van Muijen, M.3
De Jong, J.4
Van Der Vijgh, W.J.F.5
Pinedo, H.M.6
-
72
-
-
0023840693
-
Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans
-
[72] Mross, K., Maesson, P., van der Vijgh, W.J.F., Gall, H., Boven, E. and Pinedo, H.M. (1988) Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans. J. Clin. Oncol. 6, 517-526.
-
(1988)
J. Clin. Oncol.
, vol.6
, pp. 517-526
-
-
Mross, K.1
Maesson, P.2
Van Der Vijgh, W.J.F.3
Gall, H.4
Boven, E.5
Pinedo, H.M.6
-
73
-
-
0026569992
-
Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation
-
[73] Bosslet, K., Czech, J., Lovenz, P., Sedlacek, H.H., Schuermann, M. and Seemann, G. (1992) Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation. Br. J. Cancer 65, 234-238.
-
(1992)
Br. J. Cancer
, vol.65
, pp. 234-238
-
-
Bosslet, K.1
Czech, J.2
Lovenz, P.3
Sedlacek, H.H.4
Schuermann, M.5
Seemann, G.6
-
74
-
-
0028348376
-
Tumor-selective prodrug activation by fusion protein-mediated catalysis
-
[74] Bosslet, K., Czech, J. and Hoffmann, D. (1994). Tumor-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res. 54, 2151-2159.
-
(1994)
Cancer Res.
, vol.54
, pp. 2151-2159
-
-
Bosslet, K.1
Czech, J.2
Hoffmann, D.3
-
75
-
-
0026488537
-
Synthesis of novel targeted pro-prodrugs of anthracyclines potentially activated by a monoclonal antibody galactosidase conjugate
-
[75] Andrianomenjanahary, S., Dong, X., Florent, J-C., Gaudel, G., Gesson, J-P., Jacquesy, J-C., Koch, M., Michel, S., Mondon, M., Petit, P., Renoux, B. and Tillequin, F. (1992) Synthesis of novel targeted pro-prodrugs of anthracyclines potentially activated by a monoclonal antibody galactosidase conjugate. Biorg. Med. Chem. Lett. 9, 1093-1096.
-
(1992)
Biorg. Med. Chem. Lett.
, vol.9
, pp. 1093-1096
-
-
Andrianomenjanahary, S.1
Dong, X.2
Florent, J.-C.3
Gaudel, G.4
Gesson, J.-P.5
Jacquesy, J.-C.6
Koch, M.7
Michel, S.8
Mondon, M.9
Petit, P.10
Renoux, B.11
Tillequin, F.12
-
76
-
-
0028043912
-
Prodrugs of anthracyclines for chemotherapy via enzyme-monoclonal antibody conjugates
-
[76] Gesson, J-P., Jacquesy, J-C., Mondon, M., Petit, P., Renoux, B., Andrianomenjanahary, S., Dufat-Trink Van, H., Koch, M., Michel, S., Tillequin, F., Florent, J-C., Monneret, C., Bosslet, K., Czech, J. and Huffman, D. (1994) Prodrugs of anthracyclines for chemotherapy via enzyme-monoclonal antibody conjugates. Anti-Cancer Drug Des. 9, 409-423.
-
(1994)
Anti-cancer Drug Des.
, vol.9
, pp. 409-423
-
-
Gesson, J.-P.1
Jacquesy, J.-C.2
Mondon, M.3
Petit, P.4
Renoux, B.5
Andrianomenjanahary, S.6
Van Dufat-Trink, H.7
Koch, M.8
Michel, S.9
Tillequin, F.10
Florent, J.-C.11
Monneret, C.12
Bosslet, K.13
Czech, J.14
Huffman, D.15
-
77
-
-
0000283906
-
Antibody-guided enzyme nitrile therapy (AGENT): In vitro cytotoxicity and in vivo localisation
-
A.A. Epenetos (Ed.), Chapman and Hall. London
-
[77] Rowlinson-Busza, G., Bamias, A., Kraus, T. and Epenetos, A.A. (1992) Antibody-guided enzyme nitrile therapy (AGENT): in vitro cytotoxicity and in vivo localisation. In: A.A. Epenetos (Ed.), Monoclonal Antibodies. Applications in Clinical Oncology. Chapman and Hall. London, pp. 111-118.
-
(1992)
Monoclonal Antibodies. Applications in Clinical Oncology
, pp. 111-118
-
-
Rowlinson-Busza, G.1
Bamias, A.2
Kraus, T.3
Epenetos, A.A.4
-
78
-
-
0000668897
-
Two step strategies for the diagnosis and treatment of cancer with bioconjugates
-
[78] Bamias, A. and Epenetos. A.A. (1992) Two step strategies for the diagnosis and treatment of cancer with bioconjugates. Antibody Immunoconjugates Radiopharm. 5, 385-395.
-
(1992)
Antibody Immunoconjugates Radiopharm.
, vol.5
, pp. 385-395
-
-
Bamias, A.1
Epenetos, A.A.2
-
79
-
-
0023969411
-
Specific killing of human endothelial cells by antibody-conjugated glucose oxidase
-
[79] Muzykantov, V.R., Sakharov, D.V., Sinitsyn, V.V., Domogatsky, S.P., Goncharov, N.V. and Danilov, S.M. (1988) Specific killing of human endothelial cells by antibody-conjugated glucose oxidase. Anal. Biochem. 169, 383-389.
-
(1988)
Anal. Biochem.
, vol.169
, pp. 383-389
-
-
Muzykantov, V.R.1
Sakharov, D.V.2
Sinitsyn, V.V.3
Domogatsky, S.P.4
Goncharov, N.V.5
Danilov, S.M.6
-
80
-
-
0024474054
-
Immunotoxins containing glucose oxidase and lacteroperoxidase with tumoricidal properties: In vitro killing effectiveness in a mouse plasmacytoma cell model
-
[80] Stanislawski, M., Rousseau, V., Goavec, M. and Ito, M. (1989) Immunotoxins containing glucose oxidase and lacteroperoxidase with tumoricidal properties: In vitro killing effectiveness in a mouse plasmacytoma cell model. Cancer Res. 49, 5497-5504.
-
(1989)
Cancer Res.
, vol.49
, pp. 5497-5504
-
-
Stanislawski, M.1
Rousseau, V.2
Goavec, M.3
Ito, M.4
-
81
-
-
0023778726
-
Selective cytotoxicity of an oxygen radical-generating enzyme conjugated to a monoclonal antibody
-
[81] Battelli, M.G., Abbondanza, A., Tazzari, P.L., Dinota, A., Rizzi, S., Grassi, G., Gobbi, M. and Stirpe, F. (1988) Selective cytotoxicity of an oxygen radical-generating enzyme conjugated to a monoclonal antibody. Clin. Exp. Immunol. 73, 128-133.
-
(1988)
Clin. Exp. Immunol.
, vol.73
, pp. 128-133
-
-
Battelli, M.G.1
Abbondanza, A.2
Tazzari, P.L.3
Dinota, A.4
Rizzi, S.5
Grassi, G.6
Gobbi, M.7
Stirpe, F.8
-
82
-
-
0025373221
-
Cyotoxicity of glucose oxidase conjugated with antibodies to target cells: Killing efficiency depends on the conjugate internalisation
-
[82] Muzykantov, V.R., Trubetskaya, O.V., Puchnina, E.A., Sakharov, D.V. and Domogatsky, S.P. (1990) Cyotoxicity of glucose oxidase conjugated with antibodies to target cells: Killing efficiency depends on the conjugate internalisation. Biochim. Biophys. Acta 1053, 27-31.
-
(1990)
Biochim. Biophys. Acta
, vol.1053
, pp. 27-31
-
-
Muzykantov, V.R.1
Trubetskaya, O.V.2
Puchnina, E.A.3
Sakharov, D.V.4
Domogatsky, S.P.5
-
83
-
-
0011338024
-
-
World Patent Application WO 91/09134
-
[83] Takeda Chemical Industries Ltd. (1991) World Patent Application WO 91/09134.
-
(1991)
-
-
-
84
-
-
0011365285
-
-
Ph.D. Thesis, Open University, Milton Keynes, UK
-
[84] Sims, M.A. (1994) Azoreductases in cancer therapy. Ph.D. Thesis, Open University, Milton Keynes, UK.
-
(1994)
Azoreductases in Cancer Therapy
-
-
Sims, M.A.1
-
85
-
-
0023022559
-
Prodrugs in cancer chemotherapy
-
[85] Connors, T.A. (1986) Prodrugs in cancer chemotherapy, Xenobiotica 16, 975-988.
-
(1986)
Xenobiotica
, vol.16
, pp. 975-988
-
-
Connors, T.A.1
-
86
-
-
0027523517
-
A first step in the development of gene therapy for colorectal carcinoma: Cloning, sequencing and expression of Escherichia coli cytosine deaminase
-
[86] Austin, E.A. and Huber, B.E. (1993) A first step in the development of gene therapy for colorectal carcinoma: Cloning, sequencing and expression of Escherichia coli cytosine deaminase. Mol. Pharmacol. 43, 380-387.
-
(1993)
Mol. Pharmacol.
, vol.43
, pp. 380-387
-
-
Austin, E.A.1
Huber, B.E.2
-
87
-
-
0026599586
-
Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selection system
-
[87] Mullen, C.A., Kilstrup, M. and Blaese, R.M. (1992) Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc. Natl. Acad. Sci. USA 89, 33-37.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 33-37
-
-
Mullen, C.A.1
Kilstrup, M.2
Blaese, R.M.3
-
88
-
-
0027496518
-
In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase
-
[88] Huber, B.E., Austin, E.A., Goode, S.S., Knick, V.C., Tibbels, S. and Richards, C.A. (1993) In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res. 53, 4619-4626.
-
(1993)
Cancer Res.
, vol.53
, pp. 4619-4626
-
-
Huber, B.E.1
Austin, E.A.2
Goode, S.S.3
Knick, V.C.4
Tibbels, S.5
Richards, C.A.6
-
89
-
-
0028989592
-
5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory
-
[89] Consalvo, M., Mullen, C.A., Modesti, A., Musiani, P., Allione, A., Cavallo, F., Giovarelli, M. and Forni, G. (1995) 5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory. J. Immunol. 154, 5302-5312.
-
(1995)
J. Immunol.
, vol.154
, pp. 5302-5312
-
-
Consalvo, M.1
Mullen, C.A.2
Modesti, A.3
Musiani, P.4
Allione, A.5
Cavallo, F.6
Giovarelli, M.7
Forni, G.8
-
90
-
-
0024041143
-
Antiviral activity and mechanism of action of ganciclovir
-
[90] Matthews, T. and Boehine, R. (1988) Antiviral activity and mechanism of action of ganciclovir. Rev. Infect. Dis. 10. 5490-5494.
-
(1988)
Rev. Infect. Dis.
, vol.10
, pp. 5490-5494
-
-
Matthews, T.1
Boehine, R.2
-
91
-
-
0022485359
-
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
-
[91] Moolten, F. (1986) Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res. 6, 5276-5281.
-
(1986)
Cancer Res.
, vol.6
, pp. 5276-5281
-
-
Moolten, F.1
-
92
-
-
0027255414
-
Use of tissue specific expression of the Herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA
-
[92] Vile, R.G. and Hart, I.R. (1993) Use of tissue specific expression of the Herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA. Cancer Res. 53, 3860-3864.
-
(1993)
Cancer Res.
, vol.53
, pp. 3860-3864
-
-
Vile, R.G.1
Hart, I.R.2
-
93
-
-
0028919347
-
Inhibition of melanoma growth by adenoviralmediated HSV thymidine kinase gene transfer in vivo
-
[93] Bonnekoh, B., Greenhalgh, D.A., Bundman, D.S., Eckhardt, J.N., Langley, M.A., Chen, S-H., Woo, S.L.C. and Roop, D.R. (1995) Inhibition of melanoma growth by adenoviralmediated HSV thymidine kinase gene transfer in vivo. J. Invest. Dermatol. 104, 313-317.
-
(1995)
J. Invest. Dermatol.
, vol.104
, pp. 313-317
-
-
Bonnekoh, B.1
Greenhalgh, D.A.2
Bundman, D.S.3
Eckhardt, J.N.4
Langley, M.A.5
Chen, S.-H.6
Woo, S.L.C.7
Roop, D.R.8
-
94
-
-
0028116059
-
Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of Herpes simplex virus thymidine kinase gene
-
[94] Osaki, T., Tanio, Y., Tachibana, I., Hosoe, S., Kumagai, I., Kawase, I., Oikawa, S. and Kishimoto, T. (1994) Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of Herpes simplex virus thymidine kinase gene. Cancer Res. 54, 5258-5261.
-
(1994)
Cancer Res.
, vol.54
, pp. 5258-5261
-
-
Osaki, T.1
Tanio, Y.2
Tachibana, I.3
Hosoe, S.4
Kumagai, I.5
Kawase, I.6
Oikawa, S.7
Kishimoto, T.8
-
95
-
-
0028951470
-
Retrovirally transmitted gene therapy for gastric carcinoma using Herpes simplex thymidine kinase gene
-
[95] Yoshida, K., Kawami, H., Yamaguchi, Y., Kuniyasu, H., Nishiyama, M., Hirai, T., Yanagihara, K., Tahara, E. and Toge, T. (1995) Retrovirally transmitted gene therapy for gastric carcinoma using Herpes simplex thymidine kinase gene. Cancer Suppl. 75, 1467-1471.
-
(1995)
Cancer Suppl.
, vol.75
, pp. 1467-1471
-
-
Yoshida, K.1
Kawami, H.2
Yamaguchi, Y.3
Kuniyasu, H.4
Nishiyama, M.5
Hirai, T.6
Yanagihara, K.7
Tahara, E.8
Toge, T.9
-
96
-
-
0028148134
-
Directed enzyme prodrug gene therapy for pancreatic cancer in vivo
-
[96] DiMaio, J.M., Clary, B.M., Via, D.F., Coveney, E., Pappas, T.N. and Lyerly, H.K. (1994) Directed enzyme prodrug gene therapy for pancreatic cancer in vivo. Surgery 116, 205-213.
-
(1994)
Surgery
, vol.116
, pp. 205-213
-
-
DiMaio, J.M.1
Clary, B.M.2
Via, D.F.3
Coveney, E.4
Pappas, T.N.5
Lyerly, H.K.6
-
97
-
-
0028905561
-
Combination gene therapy for liver metastasis of colon carcinoma in vivo
-
[97] Chen, S-H., Chen, X.H.L., Wang. Y., Kosai, K-I., Finegold, M.J., Rich, S.S. and Woo, S.L.C. (1995) Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc. Natl. Acad. Sci. USA 92, 2577-2581.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 2577-2581
-
-
Chen, S.-H.1
Chen, X.H.L.2
Wang, Y.3
Kosai, K.-I.4
Finegold, M.J.5
Rich, S.S.6
Woo, S.L.C.7
-
98
-
-
0026772206
-
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
-
[98] Culver, K.W., Ram, Z., Watlbridge, S., Ishii, H., Oldfield, E.H. and Blaese, R.M. (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
-
(1992)
Science
, vol.256
, pp. 1550-1552
-
-
Culver, K.W.1
Ram, Z.2
Watlbridge, S.3
Ishii, H.4
Oldfield, E.H.5
Blaese, R.M.6
-
99
-
-
0027531548
-
In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
-
[99] Ram, Z., Culver, K.W., Wallbridge, S., Blaese, R.M. and Oldfield, E.H. (1993) In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res. 53, 83-88.
-
(1993)
Cancer Res.
, vol.53
, pp. 83-88
-
-
Ram, Z.1
Culver, K.W.2
Wallbridge, S.3
Blaese, R.M.4
Oldfield, E.H.5
-
100
-
-
0028038843
-
Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the Herpes simplex thymidine kinase gene/ganciclovir system
-
[100] Culver, K.W., Van Gilder, J., Link, C.J., Carlstrom, T., Buroker, T., Yuh, W., Koch, K., Schabold, K., Doornbas, S., Wetjen, B. and Blease, R.M. (1994) Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the Herpes simplex thymidine kinase gene/ganciclovir system. Hum. Gene Ther. 5, 343-379.
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 343-379
-
-
Culver, K.W.1
Van Gilder, J.2
Link, C.J.3
Carlstrom, T.4
Buroker, T.5
Yuh, W.6
Koch, K.7
Schabold, K.8
Doornbas, S.9
Wetjen, B.10
Blease, R.M.11
-
101
-
-
0029609610
-
Expression of bacterial nitroreductase in mammalian cells renders them selectively sensitive to killing by CB 1954
-
[101] Bridgewater, J., Minton, N.P., Michael, N.P., Knox, R., Springer, C. and Collins, M. (1995) Expression of bacterial nitroreductase in mammalian cells renders them selectively sensitive to killing by CB 1954. Eur. J. Cancer 31, 2362-2370.
-
(1995)
Eur. J. Cancer
, vol.31
, pp. 2362-2370
-
-
Bridgewater, J.1
Minton, N.P.2
Michael, N.P.3
Knox, R.4
Springer, C.5
Collins, M.6
-
102
-
-
0027314590
-
Gene therapy for cancer
-
[102] Sikora, K. (1993) Gene therapy for cancer. Trends Biotechnol. 11, 197-201.
-
(1993)
Trends Biotechnol.
, vol.11
, pp. 197-201
-
-
Sikora, K.1
-
103
-
-
0027483695
-
The 'bystander effect': Tumour regression when a fraction of tumor mass is genetically modified
-
[103] Freeman, S.M., Abboud, C.N., Whartenby, K.A., Packman, C.H., Koeplin, D.S., Moolten, F.L. and Abraham, G.N. (1993) The 'bystander effect': tumour regression when a fraction of tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
-
(1993)
Cancer Res.
, vol.53
, pp. 5274-5283
-
-
Freeman, S.M.1
Abboud, C.N.2
Whartenby, K.A.3
Packman, C.H.4
Koeplin, D.S.5
Moolten, F.L.6
Abraham, G.N.7
-
104
-
-
0028076759
-
Antibody-catalyzed prodrug activation
-
[104] Campbell, D.A., Gong, B., Kochersperger, L.M., Yonkovich, S., Gallop, M.A. and Schultz, P.G. (1994) Antibody-catalyzed prodrug activation. J. Am. Chem. Soc. 116, 2165-2166.
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 2165-2166
-
-
Campbell, D.A.1
Gong, B.2
Kochersperger, L.M.3
Yonkovich, S.4
Gallop, M.A.5
Schultz, P.G.6
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