The interplay between genotype, metabolic state and cofactor treatment governs phenylalanine hydroxylase function and drug response

Human Molecular Genetics

Volumn 20, Issue 13, 2011, Pages 2628-2641

  Staudigl, Michael ^a   Gersting, Søren W ^a   Danecka, Marta K ^a   Messing, Dunja D ^a   Woidy, Mathias ^a   Pinkas, Daniel ^a   Kemter, Kristina F ^a,d   Blau, Nenad ^b,c   Muntau, Ania C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d LEUKOCARE AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BORANE DERIVATIVE; PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; RECOMBINANT ENZYME;

ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME KINETICS; EUKARYOTIC CELL; FLUORESCENCE; GENE MUTATION; GENOTYPE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; METABOLISM; PRIORITY JOURNAL; PROTEIN FUNCTION;

BIOPTERIN; COENZYMES; ENZYME ACTIVATION; GENOTYPE; HEK293 CELLS; HUMANS; KINETICS; MOLECULAR CHAPERONES; MUTATION; PHENYLALANINE; PHENYLALANINE HYDROXYLASE; PHENYLKETONURIAS;

EUKARYOTA;

EID: 79958701858     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr165     Document Type: Article

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