Discovery of novel xanthone derivatives as xanthine oxidase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 4013-4015

  Hu, Lina ^a   Hu, Honggang ^a   Wu, Weifeng ^b   Chai, Xiaoyun ^a   Luo, Jianfei ^a   Wu, Qiuye ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

Derivatives; Molecular modeling; Synthesis; Xanthine oxidase; Xanthone

Indexed keywords

ALLOPURINOL; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR; XANTHONE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MOLECULAR DOCKING; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ALLOPURINOL; CATALYTIC DOMAIN; ENZYME ACTIVATION; ENZYME INHIBITORS; HYDROGEN BONDING; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; XANTHINE OXIDASE; XANTHONES;

EID: 79958701783     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.140     Document Type: Article

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