Synthesis, structure and cytotoxicity of 3-C, N, S, Se substituted benzo[b]selenophene derivatives

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3434-3443

  Arsenyan, Pavel ^a   Paegle, Edgars ^a   Belyakov, Sergey ^a   Shestakova, Irina ^a   Jaschenko, Elina ^a   Domracheva, Ilona ^a   Popelis, Juris ^a  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

Author keywords

Amination; Arylation; Benzo b selenophene; Cytotoxic activity; Morphology; Selenium; X ray

Indexed keywords

11 SELENA 5,7,9A TRIAZABENZO[B]FLUOREN 10 ONE; 11 SELENA 5,9A 8 CHLOROBENZO[B]FLUOREN 10 ONE; 11 SELENA 5,9A DIAZABENZO[B]FLUOREN 10 ONE; 3 (2 PYRIDYL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (2 PYRIMIDYLTHIO)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (3,4,5TRIFLUOROPHENYL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (4 CYANOPHENYL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (4 ISOPROPOXYPHENYL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (5 METHYLTHIEN 2 YL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (CYCLOHEX 1 ENYLETHYNYL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (PYRID 2 YLTHIO)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (PYRID 3 YLAMINO)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (PYRID 4 YLAMINO)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 (THIEN-3-YL)BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 [2 (N METHYLIMIDAZOLYLTHIO)]BENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 BROMOBENZO[B]SELENOPHENE; 3 PHENYLAMINOBENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 PHENYLBENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 PHENYLETHYNYLBENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 PHENYLSELENOBENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 3 PHENYLTHIOBENZO[B]SELENOPHENE 2 CARBOXYLIC ACID ETHYL ESTER; 6 CHLORO 8 TRIFLUOROMETHYL 11 SELENA 5,9A 8 CHLOROBENZO[B]FLUOREN 10 ONE; 7 METHYL 9H THIAZOLO[3,2 A]BENZO[B]SELENOPHENO[3,2 D]PYRIMIDIN 9 ONE; 8 SELENA 1,6A,13 TRIAZA INDENO [2,1 B]PHENANTHREN 7 ONE; 9 METHYL 11 SELENA 5,9A DIAZABENZO[B]FLUOREN 10 ONE; 9H BENZTHIAZOLO[3,2 A]BENZO[B]SELENOPHENO[3,2 D]PYRIMIDIN 9 ONE; BATRACYLIN; DIETHYL 3,3' THIODIBENZO[B]SELENOPHENE 2 CARBOXYLATE; SELENIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; SUBSTITUTION REACTION;

ACRIDINE ORANGE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBON; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; FIBROSARCOMA; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; NITROGEN; SELENIUM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; THIOPHENES;

EID: 79958292675     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.008     Document Type: Article

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