Synthesis of the antitumoural agent batracylin and related isoindolo[1,2-b]quinazolin-12(10H)-ones

Tetrahedron Letters

Volumn 48, Issue 6, 2007, Pages 1023-1026

  Martínez Viturro, Carlos M ^a   Domínguez, Domingo ^a  

^a CSIC   (Spain)

Author keywords

Batracylin; Mitsunobu reaction; Quinazolines; Quinazolinones

Indexed keywords

ANTINEOPLASTIC AGENT; BATRACYLIN; QUINAZOLINONE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; METHODOLOGY; MITSUNOBU REACTION; SUBSTITUTION REACTION;

EID: 33846084867     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.11.168     Document Type: Article

References (16)

1. Dzierzbicka K., Trzonkowski P., Sewerynek P.L., and Mysliwski A. J. Med. Chem. 46 (2003) 978
2. Guillaumel J., Léonce S., Pierre A., Renard P., Pfeiffer B., Arimondo P.B., and Monneret C. Eur. J. Med. Chem. 41 (2006) 379
3. Yilin R., Yun Feng C., Ting C., Chen A.Y., Yu C., Liu L.F., and Cheng C.C. Pharm. Res. 10 (1993) 918
4. Michael J.P. Nat. Prod. Rep. 22 (2005) 627
5. Decker M. Eur. J. Med. Chem. 40 (2005) 305
6. Anderskewitz R., Bauer R., Bodenbach G., Gester D., Gramlich B., Morschäuser G., and Birke F.W. Bioorg. Med. Chem. Lett. 15 (2005) 669
7. An alternative cyclisation based on an intramolecular aza-Wittig reaction has been achieved:. Eguchi S., and Goto S. Heterocycl. Commun. 1 (1994) 51
8. Kabbe H.J. Justus Liebigs Ann. Chem. (1978) 398
9. Meegalla S.K., Stevens G.J., McQueen C.A., Chen A.Y., Yu C., Liu L.F., Barrows L.R., and LaVoie E.J. J. Med. Chem. 37 (1994) 3434
10. Rosevear J., and Wilshire J.F.K. Aust. J. Chem. 43 (1990) 339
11. Mitsunobu O. Synthesis (1981) 1
12. Nguyen P., Corpuz E., Heidelbaugh T.M., Chow K., and Garst M.E. J. Org. Chem. 68 (2003) 10195
13. 2O, 310.1106. Found, 310.1100.
14. For the starting compounds, see:. Adger B.M., Rees C.W., and Storr R.C. J. Chem. Soc., Perkin Trans. 1 (1975) 45 [for (2-aminophenyl)(4-methoxyphenyl)methanone]
15. Hasegawa H., Muraoka M., Ohmori M., Matsui K., and Kojima A. Bioorg. Med. Chem. 13 (2005) 3721 for (2-aminophenyl)(3-methoxyphenyl)methanone
16. For the starting (2-aminophenyl)(pyridine-2-yl)methanone, see:. Fryer R.I., Zhang P., and Rios R. Synth. Commun. 23 (1993) 985