Lidocaine (lignocaine) dosing regimen based upon a population pharmacokinetic model for preterm and term neonates with seizures

Clinical Pharmacokinetics

Volumn 50, Issue 7, 2011, Pages 461-469

  Van Den Broek, Marcel P H ^a   Huitema, Alwin D R ^b   Van Hasselt, Johan G C ^b   Groenendaal, Floris ^c   Toet, Mona C ^c   Egberts, Toine C G ^a,d   De Vries, Linda S ^c   Rademaker, Catharine M A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antiepileptic drugs; Dose prediction; Drug monitoring; Epilepsy; Lidocaine; Neonates; Pharmacokinetic modelling; Seizures

Indexed keywords

LIDOCAINE;

ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; FEMALE; GESTATIONAL AGE; HUMAN; INFANT; LOADING DRUG DOSE; MALE; MODEL; NEWBORN; POPULATION RESEARCH; PREMATURITY; PRIORITY JOURNAL; SEIZURE; SIMULATION; TERM BIRTH; TREATMENT PLANNING;

ANTICONVULSANTS; ARRHYTHMIAS, CARDIAC; CLINICAL PROTOCOLS; DRUG MONITORING; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; LIDOCAINE; MALE; MODELS, STATISTICAL; SCANDINAVIA; SEIZURES;

EID: 79958260732     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.2165/11589160-000000000-00000     Document Type: Article

References (42)

1. Pardridge WM, Sakiyama R, Fierer G. Blood-brain barrier transport and brain sequestration of propranolol and lidocaine. Am J Physiol 1984; 247 (3 Pt 2): R582-8. (Pubitemid 14003650)
2. Simon RP, Benowitz NL, Bronstein J, et al. Increased brain uptake of lidocaine during bicuculline-induced status epilepticus in rats. Neurology 1982; 32 (2): 196-9. (Pubitemid 12224005)
3. Hellstrom-Westas L, Westgren U, Rosen I, et al. Lidocaine for treatment of severe seizures in newborn infants: I. Clinical effects and cerebral electrical activity monitoring. Acta Paediatr Scand 1988; 77 (1): 79-84. (Pubitemid 18081548)
4. Warnick JE, Kee RD, Yim GK. The effects of lidocaine on inhibition in the cerebral cortex. Anesthesiology 1971; 34 (4): 327-32.
5. Norell E, Gamstorp I. Neonatal seizures: effect of lidocain. Acta Paediatr Scand Suppl 1970; 206 Suppl 206: 97.
6. Hellstrom-WestasL, SvenningsenNW,WestgrenU, et al.Lidocaine for treatment of severe seizures in newborn infants: II. Blood concentrations of lidocaine and metabolites during intravenous infusion. Acta Paediatr 1992; 81 (1): 35-9.
7. Rademaker CMA, de Vries LS. Pharmacology review: lidocaine for neonatal seizure management. NeoReviews 2008; 9: e585-9.
8. Vento M, de Vries LS, Alberola A, et al. Approach to seizures in the neonatal period: a European perspective. Acta Paediatr 2010; 99 (4): 497-501.
9. Edgren B, Tilelli J, Gehrz R. Intravenous lidocaine overdosage in a child. J Toxicol Clin Toxicol 1986; 24 (1): 51-8. (Pubitemid 16084087)
10. Jonville AP, Barbier P, Blond MH, et al. Accidental lidocaine overdosage in an infant. J Toxicol Clin Toxicol 1990; 28 (1): 101-6. (Pubitemid 20246957)
11. van Rooij LG, Toet MC, Rademaker KM, et al. Cardiac arrhythmias in neonates receiving lidocaine as anticonvulsive treatment. Eur J Pediatr 2004; 163 (11): 637-41. (Pubitemid 39517885)
12. Lie KI, Wellens HJ, van Capelle FJ, et al. Lidocaine in the prevention of primary ventricular fibrillation: a double-blind, randomized study of 212 consecutive patients. N Engl J Med 1974; 291 (25): 1324-6.
13. Centini F, Fiore C, Riezzo I, et al. Suicide due to oral ingestion of lidocaine: a case report and review of the literature. Forensic Sci Int 2007; 171 (1): 57-62. (Pubitemid 47176305)
14. Malingre MM, Van Rooij LG, Rademaker CM, et al. Development of an optimal lidocaine infusion strategy for neonatal seizures. Eur J Pediatr 2006; 165 (9): 598-604. (Pubitemid 44134219)
15. Kearns GL, Abdel-Rahman SM, Alander SW, et al. Developmental pharmacology: drug disposition, action, and therapy in infants and children. N Engl J Med 2003; 349 (12): 1157-67. (Pubitemid 37122329)
16. Beal SL, Boeckman AJ, Sheiner LB. NONMEM: user's guides. San Francisco (CA): University of California at San Francisco, 1988-1992.
17. Keizer RJ, van Benten M, Beijnen JH, et al. Pirana and PCluster: a modeling environment and cluster infrastructure for NONMEM. Comput Methods Programs Biomed 2011 Jan; 101 (1): 72-9.
18. Karlsson MO, Savic RM. Diagnosing model diagnostics. Clin Pharmacol Ther 2007; 82 (1): 17-20. (Pubitemid 46944205)
19. Ette EI, Ludden TM. Population pharmacokinetic modeling: the importance of informative graphics. Pharm Res 1995; 12 (12): 1845-55. (Pubitemid 26031769)
20. Ette EI. Statistical graphics in pharmacokinetics and pharmacodynamics: a tutorial. Ann Pharmacother 1998; 32 (7-8): 818-28. (Pubitemid 28341114)
21. Anderson BJ, Holford NH. Mechanistic basis of using body size and maturation to predict clearance in humans. Drug Metab Pharmacokinet 2009; 24 (1): 25-36.
22. Ette EI. Stability and performance of a population pharmacokinetic model. J Clin Pharmacol 1997; 37 (6): 486-95. (Pubitemid 27265649)
23. Comets E, Brendel K, Mentre F. Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R. Comput Methods Programs Biomed 2008; 90 (2): 154-66.
24. Brendel K, Comets E, Laffont C, et al. Evaluation of different tests based on observations for external model evaluation of population analyses. J Pharmacokinet Pharmacodyn 2010; 37 (1): 49-65.
25. Mentre F, Escolano S. Prediction discrepancies for the evaluation of nonlinear mixed-effects models. J Pharmacokinet Pharmacodyn 2006; 33 (3): 345-67. (Pubitemid 44020385)
26. van Rooij LG, Toet MC, van Huffelen AC, et al. Effect of treatment of subclinical neonatal seizures detected with aEEG: randomized, controlled trial. Pediatrics 2010; 125 (2): e358-66.
27. Thibeault-Eybalin MP, Lortie A, Carmant L. Neonatal seizures: do they damage the brain? Pediatr Neurol 2009; 40 (3): 175-80.
28. Benowitz NL, Meister W. Clinical pharmacokinetics of lignocaine. Clin Pharmacokinet 1978; 3 (3): 177-201. (Pubitemid 8333335)
29. Lerman J, Strong HA, LeDez KM, et al. Effects of age on the serum concentration of alpha 1-acid glycoprotein and the binding of lidocaine in pediatric patients. Clin Pharmacol Ther 1989; 46 (2): 219-25. (Pubitemid 19219959)
30. Hines RN. The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacol Ther 2008; 118 (2): 250-67.
31. deWildt SN, Kearns GL, Leeder JS, et al. Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet 1999; 37 (6): 485-505. (Pubitemid 30032252)
32. Hines RN, McCarver DG. The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Ther 2002; 300 (2): 355-60. (Pubitemid 34106223)
33. Mazoit JX, Dalens BJ. Pharmacokinetics of local anaesthetics in infants and children. Clin Pharmacokinet 2004; 43 (1): 17-32. (Pubitemid 38186931)
34. Thomson AH, Elliott HL, Kelman AW, et al. The pharmacokinetics and pharmacodynamics of lignocaine and MEGX in healthy subjects. J Pharmacokinet Biopharm 1987; 15 (2): 101-15. (Pubitemid 17121512)
35. Strong JM, Mayfield DE, Atkinson Jr AJ, et al. Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide. Clin Pharmacol Ther 1975; 17 (2): 184-94.
36. Alderman EL, Kerber RE, Harrison DC. Evaluation of lidocaine resistance in man using intermittent large-dose infusion techniques. Am J Cardiol 1974; 34 (3): 342-9.
37. Liu PL, Feldman HS, Giasi R, et al. Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. Anesth Analg 1983; 62 (4): 375-9. (Pubitemid 13161142)
38. DeToledo JC. Lidocaine and seizures. Ther Drug Monit 2000; 22 (3): 320-2.
39. Satas S, Johannessen SI, Hoem NO, et al. Lidocaine pharmacokinetics and toxicity in newborn pigs. Anesth Analg 1997; 85 (2): 306-12. (Pubitemid 27349138)
40. Bernhard CG, Bohm E. The action of local anaesthetics on experimental epilepsy in cats and monkeys. Br J Pharmacol Chemother 1955; 10 (3): 288-95.
41. Rey E, Radvanyi-Bouvet MF, Bodiou C, et al. Intravenous lidocaine in the treatment of convulsions in the neonatal period: monitoring plasma levels. Ther Drug Monit 1990; 12 (4): 316-20. (Pubitemid 20240634)
42. van den Broek MP, Groenendaal F, Egberts AC, et al. Effects of hypothermia on pharmacokinetics and pharmacodynamics: a systematic review of preclinical and clinical studies. Clin Pharmacokinet 2010; 49 (5): 277-94