Mesenchymal stromal cells: More than inhibitory cells

Leukemia

Volumn 25, Issue 4, 2011, Pages 565-566

  Krampera, M ^a  

^a UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; INDOLEAMINE 2,3 DIOXYGENASE;

ANIMAL; DRUG EFFECT; ENZYMOLOGY; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MESENCHYMAL STEM CELL; METABOLISM; NOTE; STROMA CELL;

ANIMALS; ANTIVIRAL AGENTS; HUMANS; IMMUNE TOLERANCE; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; MESENCHYMAL STEM CELLS; STROMAL CELLS;

EID: 79958250103     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.8     Document Type: Editorial

References (20)

1. Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-650.
2. Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, Marini FC et al. Clarification of the nomenclature for MSC: the international society for cellular therapy position statement. Cytotherapy 2005; 7: 393-395.
3. Haniffa MA, Collin MP, Buckley CD, Dazzi F. Mesenchymal stem cells: the fibroblasts’ new clothes? Haematologica 2009; 94: 258-263
4. da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006; 119: 2204-2213.
5. Amé-Thomas P, Maby-El Hajjami H, Monvoisin C, Jean R, Monnier D, Caulet-Maugendre S et al. Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis. Blood 2007; 109: 693-702.
6. Krampera M, Sartoris S, Cosmi L, Pasini A, Angeli R, Liotta F et al. Immune regulation by mesenchymal stem cells derived from adult spleen and thymus. Stem Cells Dev 2007; 16: 797-810.
7. Jones S, Horwood N, Cope A, Dazzi F. The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells. J Immunol 2007; 179: 2824-2831.
8. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371: 1579-1586.
9. Ball LM, Bernardo ME, Roelofs H, Lankester A, Cometa A, Egeler RM et al. Cotransplantation of ex vivo expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation. Blood 2007; 110: 2764-2767.
10. Kang HS, Habib M, Chan J, Abavana C, Potian JA, Ponzio NM et al. A paradoxical role for IFNgamma in the immune properties of mesenchymal stem cells during viral challenge. Exp Hematol 2005; 33: 796-803.
11. Sundin M, Orvell C, Rasmusson I, Sundberg B, Ringden O, Le Blanc K. Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual. Bone Marrow Transplant 2006; 37: 1051-1059.
12. Morandi F, Raffaghello L, Bianchi G, Meloni F, Salis A, Millo E et al. Immunogenicity of human mesenchymal stem cells in HLAclass I-restricted T-cell responses against viral or tumor-associated antigens. Stem Cells 2008; 26: 1275-1287.
13. Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F et al. Tolllike receptors 3 and 4 are expressed by human bone marrowderived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling. Stem Cells 2008; 26: 279-289.
14. Gonzalez-Rey E, Anderson P, Gonzalez MA, Rico L, Buscher D, Delgado M. Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis. Gut 2009; 58: 929-939.
15. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation. Blood 2004; 103: 4619-4621.
16. Mellor AL, Baban B, Chandler P, Marshall B, Jhaver K, Hansen A et al. Cutting edge: induced indoleamine 2, 3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 2003; 171: 1652-1655.
17. Puccetti P, Grohmann U. IDO and regulatory T cells: a role for reverse signalling and non-canonical NF kappaB activation. Nature Rev Immunol 2007; 7: 817-823.
18. Krampera M, Cosmi L, Angeli R, Pasini A, Liotta F, Andreini A et al. Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006; 24: 386-398.
19. Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2, 3-dioxygenase and prostaglandin E2. Blood 2008; 111: 1327-1333.
20. Chan JL, Tang KC, Patel AP, Bonilla LM, Pierobon N, Ponzio NM et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood 2006; 107: 4817-4824.