Combination anti-HIV therapy with the self-assemblies of an asymmetric bolaamphiphilic zidovudine/didanosine prodrug

Molecular Pharmaceutics

Volumn 8, Issue 3, 2011, Pages 867-876

  Jin, Yiguang ^a,b   Xin, Rui ^a,b   Tong, Li ^c   Du, Lina ^a   Li, Miao ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b HENAN UNIVERSITY   (China)

^c BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Anti HIV; bolaamphiphile; didanosine; prodrug; self assembly; zidovudine

Indexed keywords

AMPHOPHILE; CHLOROFORM; CYCLOHEXANE; DEOXYCHOLIC ACID; DIDANOSINE; PRODRUG; PROTON; TETRAHYDROFURAN; UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE; ZIDOVUDINE PHOSPHORYLDEOXYCHOLYLDIDANOSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DEGRADATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; MACROPHAGE; MAXIMUM PLASMA CONCENTRATION; MONOLAYER CULTURE; MOUSE; NONHUMAN; PH; PHOSPHORYLATION; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIDANOSINE; HIV INFECTIONS; HUMANS; MICE; PRODRUGS; ZIDOVUDINE;

EID: 79958248962     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100457d     Document Type: Article

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