Ether phospholipid-AZT conjugates possessing anti-HIV and antitumor cell activity. Synthesis, conformational analysis, and study of their thermal effects on membrane bilayers

Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2001, Pages 1702-1709

  Mavromoustakos, T ^a   Calogeropoulou, T ^a   Koufaki, M ^a   Kolocouris, A ^a   Daliani, I ^a   Demetzos, C ^b   Meng, Z ^c   Makriyannis, A ^c   Balzarini, J ^d   De Clercq, E ^d  

^a INSTITUTE OF BIOLOGY   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3' AZIDO 3' DEOXYTHYMIDINE 5' [3 (1 O HEXADECYL 2 O METHYL GLYCERYL)PHOSPHATE]; 3' AZIDO 3' DEOXYTHYMIDINE 5' HEXADECYL PHOSPHODIESTER; ALKYL GROUP; ETHER PHOSPHOLIPID; GLYCEROL DERIVATIVE; MEMBRANE PHOSPHOLIPID; METHYL GROUP; THYMINE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BILAYER MEMBRANE; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROPHOBICITY; ISOMERISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; THERMAL ANALYSIS;

ANIMALS; ANTI-HIV AGENTS; ANTINEOPLASTIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CELLS, CULTURED; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCEROL; HIV-1; HIV-2; HUMANS; LIPID BILAYERS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEOSIDES; SOLUTIONS; T-LYMPHOCYTES; THYMIDINE KINASE; ZIDOVUDINE;

EID: 0035942511     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001121c     Document Type: Article

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