Protective effect of methanolic leaf extract of Caesalpinia bonduc (L.) on gentamicin-induced hepatotoxicity and nephrotoxicity in rats

Iranian Journal of Pharmacology and Therapeutics

Volumn 10, Issue 1, 2011, Pages 21-25

  Noorani, Arshad Ali ^a   Gupta, Karan Ajay ^a   Bhadada, Khushboo ^a   Kale, M K ^b  

^a Mandsaur Institute of Pharmacy   (India)

^b Kai Yashodabai Dagadu Saraf Charitable Trust's   (India)

Author keywords

Caesalpinia bonduc; Gentamicin; Hepatotoxicity; Nephrotoxicitys

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CAESALPINIA BONDUC EXTRACT; CHLORIDE; METHANOL; PLANT EXTRACT; POTASSIUM; PROTEIN; SODIUM; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CAESALPINIA; CAESALPINIA BONDUC; CHLORIDE BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG SCREENING; ENZYME ACTIVITY; FEMALE; LIVER PROTECTION; LIVER TOXICITY; MALE; NEPHROTOXICITY; NONHUMAN; PLANT LEAF; POTASSIUM BLOOD LEVEL; PROTEIN BLOOD LEVEL; RAT; RENAL PROTECTION; SODIUM BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL;

EID: 79958239919     PISSN: 17352657     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Conlon BJ, Aran JM, Erre JP. Attenuation of aminoglycoside induced cochlear damage with the metabolic antioxidant alphalipoic acid. Hear Res 1999; 128:40-4.
2. Rybak LP, Whitworth CA. Ototoxicity: therapeutic opportunities. Drug Dis Today 2005; 10:1313-21.
3. Aubrecht J, Goad MEP, Simpson EM. Expression of hygR in Transgenic Mice Causes Resistance to toxic Effects of Hygromycin B In Vivo. J Pharmacol Exp Ther 1997; 281:992-7.
4. Klemens JJ, Meech RP and Hughes LF. Antioxidant enzyme levels inversely covary with hearing loss after amikacin treatment.J Am Acad Audiol 2003; 14:134-42.
5. Martines G, Butturini L and Menozzi I. Amikacin-induced liver toxicity: correlations between biochemical indexes and ultrastructural features in an experimental model. Rev Med Univ Navarra 1988; 32:41-5.
6. Pedraza CJ, Maldonado PD and Medina CO. Garlic ameliorates gentamicin nephrotoxicity: relation antioxidant enzymes. Free Radic Biol Med 2000; 29:602-11.
7. Laurent G, Carlier MB, Rollman B. Mechanism of aminoglycoside- induced lysosomal phospholipidosis: In vitro and in vivo studies with gentamycin and amikacin. Biochem Pharmacol 1982; 31:3861-70.
8. Laurent G, Kishore BK, Tulkens PM. Aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem Pharmacol1990; 40: 2383-92.
9. Gonzalez A, Jimenez A, Vazquez D. Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochem Biophys Acta 1978; 521:459-69.
10. Jethmalani, M. Sabnis, PB, Gaitonde BB. Anti-inflammatory activity of Caesalpinia bonducella. Indian J Pharm 1966; 28:314.
11. Jain S, Saraf S., Kharya MD, Dixit VK. Antimalarial Activity of Caesalpinia crista nuts. Indian J Nat Prod 1992; 8:13.
12. Gupta M, Mazumder UK, kumar R. Antioxidant Defense system Induced by a Methanol Extract of Caesalpinia bonducella in rat liver. Pharmaceutical Biology 2005; 43:411-9.
13. Kannur DM, Hukkeri VI, Akki KS. Adaptogenic activity of Caesalpinia bonduc seed extract in rats. J Ethnopharmacol 2006; 108:327-31.
14. Parameshwar S, Srinivasan KK, Mallikarjuna R. Oral antidiabetic activity of Caesalpinia bonducella seed kernels. J Pharmacel Biol 2007; 40:10-5.
15. Gupta M, Muzumder U, Kumar R. Antitumar activity and antioxidant status of Caesalpinia bonducella against ehrlich ascites carcinoma in swiss albino mice. J Pharmacol Sci 2004; 94:177-84.
16. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy, 26th ed.India, Nirali Prakashan, 2004, pp 101-10.
17. OECD, 2001. Guideline for the testing of chemicals revised draft guideline 425: acute oral toxicity. Acute toxic class method.
18. Maheshwari NR, Talele BD. Use of Achyranthes aspera against gentamicin induced liver and kidney toxicity. Research articales by budding researchers 2008; 1:22-4.
19. Schacht J, Weiner N. Aminoglycoside-induced hearing loss: a molecular hypothesis. ORL J Otorhinolaryngol Relat Spec 1986; 48: 116-23.
20. Montserrat B, Victoria L, Albina ML. Melatonin reduce uranium-induced nephrotoxicity in rats. J Pineal Res 2007; 43:87-95.
21. Bendush CL, Weber R. Tobramycin sulphate: A summary of worldwide experience form clinical trial. J Infect Dis 1976; 134:219-30.
22. Lietz T, Brya J. The effect of various aminoglycoside antibiotics on glycogen phosphorylase activity in liver and kidney medulla of rabbit. Acta Biochim Pol 1990; 37:187-90.