Expression of hyg(R) in transgenic mice causes resistance to toxic effects of hygromycin B in vivo

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 2, 1997, Pages 992-997

  Aubrecht, Jiri ^a   Goad, Mary E P ^a,b   Simpson, Elizabeth M ^a,c   Schiestl, Robert H ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MARKER; HYGROMYCIN B; PHOSPHOTRANSFERASE; ANTIINFECTIVE AGENT; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL INFECTION; GENE EXPRESSION; KIDNEY TUBULE NECROSIS; MOUSE; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROKARYOTE; PROMOTER REGION; PROTEIN SYNTHESIS; TISSUE SPECIFICITY; TRANSGENIC MOUSE; ANIMAL; ANTIBIOTIC RESISTANCE; C57BL MOUSE; GENETICS; KIDNEY; LD 50; LIVER; PATHOLOGY;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; HYGROMYCIN B; KIDNEY; LETHAL DOSE 50; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RNA, MESSENGER;

EID: 0030610429     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. BAUM, N., DICHOSO, C. C. AND CARLTON, C. E.: Blood urea nitrogen and serum creatinine. Physiology and interpretation. Urology 5: 583-8, 1975.
2. BERDY, J., CRC HANDBOOK OF ANTIBIOTIC COMPOUNDS. 1, p. 202. CRC Press, Boca Raton, 1980.
3. BLOCHLINGER, K. AND DIGGELMANN, H.: Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells. Mol. Cell. Biol. 4: 2929-31, 1984.
4. CHEN, G., BRANTON, P. E. AND SHORE, G. C.: Induction of p53-independent apoptosis by hygromycin B: Suppression by Bcl-2 and adenovirus E1B 19-kDa protein. Exp. Cell Res. 221: 55-9, 1995.
5. CHHABRA, R.S., HUFF, J.E., SCHWETZ, B.S. AND SELKIRK, J.: An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Envirn Health Perspectives 86: 313-321 (10), 1990.
6. CHOMCZYNSKI, P. AND SACCHI, N.: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
7. DEICHMANN, W. B. AND LEBLANC, T. J.: Determination of the approximate lethal dose with about six animals. J. Industrial Hygiene and Toxicology 25: 415-417, 1943.
8. ECOBICHON, D. J.: Acute toxicity studies. In The Basis of Toxicity Testing, ed. by D. J. Ecobichon, pp. 35-59, CRC Press, Boca Raton, 1992.
9. GIULIANO, R. A., VERPOOTEN, G. A., VERBIST, L., WEDEEN, R. AND DEBROE, M. E.: In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats. J. Pharmacol. Exp. Ther. 236: 470-475, 1986.
10. GONZALEZ, A., JIMENEZ, A., VAZQUEZ, D., DAVIES, J. E. AND SCHINDLER, D.: Studies on the mode of action of hygromycin B, an inhibitor of translocation in eukaryotes. Biochim. et Biophys. Acta 521: 459-69, 1978.
11. HERRERA, J. L.: Abnormal liver enzyme levels. The spectrum of causes. Postgrad. Med. 93: 113-6, 1993.
12. IARC recommendation on LD50 testing. ILAR News 35: 56-58, 1993.
13. JOHNSON, K. A., LERNER, C. P., DI LACIO, L. C., LAIRD, P. W., SHARPE, A. H. AND SIMPSON, E. M.: Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections. Nucleic Acids Res. 23: 1273-1275, 1995.
14. KUHAR, M. K., MAK, L. L. AND LIETMAN, P. S.: Autoradiographic localization of [3H]gentamycin in the proximal renal tubules of mice. Antimicrob. Agents Chemother. 15: 131-133, 1979.
15. LAURENT, G., CARLIER, M. B., ROLLMAN, B., VANHOOF, F. AND TULKENS, P. M.: Mechanism of aminoglycoside-induced lysosomal phospholipidosis: In vitro and in viro studies with gentamycin and amikacin. Biochem. Pharmacol. 31: 3861-3870, 1982.
16. LAURENT, G., KISHORE, B. K. AND TULKENS, P. M.: Aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem. Pharmacol. 40: 2383-2392, 1990.
17. LORTHOLARY, O., TOD, M., COHEN, Y. AND PETITJEAN, O.: Aminoglycosides. Med. Clin. N. Am. 79: 761-87, 1995.
18. MCBURNEY, M. W., STAINES, W. A., BOEKELHEIDE, K., PARRY, D., JARDINE, K. AND PICKAVANCE, L.: Murine PGK-1 promoter drives widespread but not uniform expression in transgenic mice. Dev. Dynam. 200: 278-93, 1994.
19. PALMITER, R. D., SANDGREN, E. P., AVARBOCK, M. R., ALLEN, D. D. AND BRINSTER, R. L.: Heterologous introns can enhance expression of transgene in mice. Proc. Natl. Acad. Sci. U.S.A. 88: 478-482, 1991.
20. PARDO, J. M., MALPARTIDA, F., RICO, M. AND JIMENEZ, A.: Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism. J. Gen. Microbiol. 131: 1289-98, 1985.
21. PETTINGER, R. C., WOLFE, R. N., HOEHN, M. M., MARKS, P. N., DAILY, W. A. AND MCGUIRE, J. M.: Hygromycin. I. Preliminary studies on the production and biological activity of a new antibiotic. Antibio. Chemother. 3: 1268-1282, 1953.
22. SANDE, M. A. AND MANDELL, G. L.: Antimicrobial agents. In The Pharmacological Basis of Therapeutics, ed. by A. Goodman Gilman, L. S. Rall and F. Murad, pp. 1150-1169, Macmillan, New York, 1985.
23. TULKENS, P. M.: Nephrotoxicity of aminoglycoside antibiotics. Toxicol. Lett. 46: 107-123, 1989.