Peroxynitrite treatment reduces adenosine uptake via the equilibrative nucleoside transporter in rat astrocytes

Neuroscience Letters

Volumn 498, Issue 1, 2011, Pages 52-56

  Tanaka, Akiko ^a   Nishida, Kentaro ^a   Okuda, Hiroto ^a   Nishiura, Takeshi ^a   Higashi, Youichirou ^a,b   Fujimoto, Sadaki ^a   Nagasawa, Kazuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Adenosine uptake; Astrocyte; Nucleoside transporter; Oxidative stress; SIN 1

Indexed keywords

3 NITROTYROSINE; ADENOSINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; LINSIDOMINE; NITROBENZYLTHIOINOSINE; PEROXYNITRITE; SODIUM;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL VIABILITY; MICHAELIS CONSTANT; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADENOSINE; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; IMMUNOHISTOCHEMISTRY; MOLSIDOMINE; NITRIC OXIDE DONORS; NUCLEOSIDE TRANSPORT PROTEINS; OXIDANTS; OXIDATIVE STRESS; PEROXYNITROUS ACID; RATS; RATS, WISTAR;

EID: 79958180123     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.04.060     Document Type: Article

References (33)

1. Baldwin S.A., Yao S.Y., Hyde R.J., Ng A.M., Foppolo S., Barnes K., Ritzel M.W., Cass C.E., Young J.D. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 2005, 280:15880-15887.
2. Bjorklund O., Shang M., Tonazzini I., Dare E., Fredholm B.B. Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage. Eur. J. Pharmacol. 2008, 596:6-13.
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
4. Bruzzone S., Guida L., Zocchi E., Franco L., De Flora A. Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. FASEB J. 2001, 15:10-12.
5. Cass C.E., Young J.D., Baldwin S.A. Recent advances in the molecular biology of nucleoside transporters of mammalian cells. Biochem. Cell Biol. 1998, 76:761-770.
6. Chaudary N., Naydenova Z., Shuralyova I., Coe I.R. Hypoxia regulates the adenosine transporter, mENT1, in the murine cardiomyocyte cell line, HL-1. Cardiovasc. Res. 2004, 61:780-788.
7. Choi H.B., Ryu J.K., Kim S.U., McLarnon J.G. Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain. J. Neurosci. 2007, 27:4957-4968.
8. Crawford C.R., Patel D.H., Naeve C., Belt J.A. Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. J. Biol. Chem. 1998, 273:5288-5293.
9. Deitmer J.W. Strategies for metabolic exchange between glial cells and neurons. Respir. Physiol. 2001, 129:71-81.
10. Dunwiddie T.V., Diao L., Proctor W.R. Adenine nucleotides undergo rapid, quantitative conversion to adenosine in the extracellular space in rat hippocampus. J. Neurosci. 1997, 17:7673-7682.
11. Frenguelli B.G., Llaudet E., Dale N. High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J. Neurochem. 2003, 86:1506-1515.
12. Gomes C.V., Kaster M.P., Tome A.R., Agostinho P.M., Cunha R.A. Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochim. Biophys. Acta 2011, 808:1380-1399.
13. Griffiths M., Yao S.Y., Abidi F., Phillips S.E., Cass C.E., Young J.D., Baldwin S.A. Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem. J. 1997, 328(Pt 3):739-743.
14. Hirsh A.J., Stonebraker J.R., van Heusden C.A., Lazarowski E.R., Boucher R.C., Picher M. Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. Biochemistry 2007, 46:10373-10383.
15. Kobayashi S., Zimmermann H., Millhorn D.E. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J. Neurochem. 2000, 74:621-632.
16. Liu G.J., Kalous A., Werry E.L., Bennett M.R. Purine release from spinal cord microglia after elevation of calcium by glutamate. Mol. Pharmacol. 2006, 70:851-859.
17. Mihm M.J., Coyle C.M., Schanbacher B.L., Weinstein D.M., Bauer J.A. Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure. Cardiovasc. Res. 2001, 49:798-807.
18. Nagai K., Nagasawa K., Fujimoto S. Transport mechanisms for adenosine and uridine in primary-cultured rat cortical neurons and astrocytes. Biochem. Biophys. Res. Commun. 2005, 334:1343-1350.
19. Nagasawa K., Escartin C., Swanson R.A. Astrocyte cultures exhibit P2X7 receptor channel opening in the absence of exogenous ligands. Glia 2009, 57:622-633.
20. Nagasawa K., Kawasaki F., Tanaka A., Nagai K., Fujimoto S. Characterization of guanine and guanosine transport in primary cultured rat cortical astrocytes and neurons. Glia 2007, 55:1397-1404.
21. Nagasawa K., Miyaki J., Kido Y., Higashi Y., Nishida K., Fujimoto S. Possible involvement of PPARγ in the regulation of basal channel opening of P2X7 receptor in cultured mouse astrocytes. Life Sci. 2009, 84:825-831.
22. Okuda H., Higashi Y., Nishida K., Fujimoto S., Nagasawa K. Contribution of P2X7 receptors to adenosine uptake by cultured mouse astrocytes. Glia 2010, 58:1757-1765.
23. Parkinson F.E., Xiong W. Stimulus- and cell-type-specific release of purines in cultured rat forebrain astrocytes and neurons. J. Neurochem. 2004, 88:1305-1312.
24. Pascual O., Casper K.B., Kubera C., Zhang J., Revilla-Sanchez R., Sul J.Y., Takano H., Moss S.J., McCarthy K., Haydon P.G. Astrocytic purinergic signaling coordinates synaptic networks. Science 2005, 310:113-116.
25. Ritzel M.W., Ng A.M., Yao S.Y., Graham K., Loewen S.K., Smith K.M., Ritzel R.G., Mowles D.A., Carpenter P., Chen X.Z., Karpinski E., Hyde R.J., Baldwin S.A., Cass C.E., Young J.D. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J. Biol. Chem. 2001, 276:2914-2927.
26. Rose J.B., Naydenova Z., Bang A., Eguchi M., Sweeney G., Choi D.S., Hammond J.R., Coe I.R. Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection. Am. J. Physiol. Heart Circ. Physiol. 2010, 298:H771-H777.
27. Srinivasan D., Yen J.H., Joseph D.J., Friedman W. Cell type-specific interleukin-1beta signaling in the CNS. J. Neurosci. 2004, 24:6482-6488.
28. Szabo C. Multiple pathways of peroxynitrite cytotoxicity. Toxicol. Lett. 2003, 140-141:105-112.
29. Tsacopoulos M., Magistretti P.J. Metabolic coupling between glia and neurons. J. Neurosci. 1996, 16:877-885.
30. Ungvari Z., Gupte S.A., Recchia F.A., Batkai S., Pacher P. Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. Curr. Vasc. Pharmacol. 2005, 3:221-229.
31. Ward J.L., Sherali A., Mo Z.P., Tse C.M. Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine. J. Biol. Chem. 2000, 275:8375-8381.
32. Webb T.E., Simon J., Krishek B.J., Bateson A.N., Smart T.G., King B.F., Burnstock G., Barnard E.A. Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett. 1993, 324:219-225.
33. Yao S.Y., Ng A.M., Vickers M.F., Sundaram M., Cass C.E., Baldwin S.A., Young J.D. Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. J. Biol. Chem. 2002, 277:24938-24948.