-
1
-
-
27844455955
-
Case history: Acyclic nucleoside phosphonates: A key class of antiviral drugs
-
DOI 10.1038/nrd1877, PII N1877
-
E. De Clercq, and A. Holý Acyclic nucleoside phosphonates: a key class of antiviral drugs Nat Rev Drug Discov 4 2005 928 940 (Pubitemid 41637695)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.11
, pp. 928-940
-
-
De Clercq, E.1
Holy, A.2
-
2
-
-
0032987941
-
Antitumor potential of acyclic nucleoside phosphonates
-
E. De Clercq, G. Andrei, J. Balzarini, S. Hatse, S. Liekens, and L. Naesens Antitumor potential of acyclic nucleoside phosphonates Nucleosides Nucleotides 18 1999 759 771 (Pubitemid 29320593)
-
(1999)
Nucleosides and Nucleotides
, vol.18
, Issue.4-5
, pp. 759-771
-
-
De Clercq, E.1
Andrei, G.2
Balzarini, J.3
Hatse, S.4
Liekens, S.5
Naesens, L.6
Neyts, J.7
Snoeck, R.8
-
3
-
-
0034052289
-
Anticancer effect of PMEDAP - Monitoring of apoptosis
-
K. Bobková, B. Otová, I. Marinov, V. Mandys, A. Panczak, and I. Votruba Anticancer effect of PMEDAP - monitoring of apoptosis Anticancer Res 20 2000 1041 1047 (Pubitemid 30240674)
-
(2000)
Anticancer Research
, vol.20
, Issue.2 A
, pp. 1041-1047
-
-
Bobkova, K.1
Otova, B.2
Marinov, I.3
Mandys, V.4
Panczak, A.5
Votruba, I.6
Holy, A.7
-
4
-
-
77955781919
-
Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells
-
H. Mertlíková-Kaiserová, I. Votruba, M. Matoušová, A. Holý, and M. Hájek Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells Anticancer Res 30 2010 2791 2798
-
(2010)
Anticancer Res
, vol.30
, pp. 2791-2798
-
-
Mertlíková-Kaiserová, H.1
Votruba, I.2
Matoušová, M.3
Holý, A.4
Hájek, M.5
-
5
-
-
52049093225
-
GS-9219 - A novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma
-
H. Reiser, J. Wang, L. Chong, W.J. Watkins, A.S. Ray, and R. Shibata GS-9219 - a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma Clin Cancer Res 14 2008 2824 2832
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2824-2832
-
-
Reiser, H.1
Wang, J.2
Chong, L.3
Watkins, W.J.4
Ray, A.S.5
Shibata, R.6
-
6
-
-
0034742549
-
6-substituted PMEDAP derivatives against T-cell lymphoma
-
M. Valeriánová, I. Votruba, A. Holý, V. Mandys, and B. Otová Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma Anticancer Res 21 2001 2057 2064 (Pubitemid 32728951)
-
(2001)
Anticancer Research
, vol.21
, Issue.3 B
, pp. 2057-2064
-
-
Valerianova, M.1
Votruba, I.2
Holy, A.3
Mandys, V.4
Otova, B.5
-
7
-
-
0025372944
-
Acyclic nucleotide analogues: Synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro
-
DOI 10.1016/0166-3542(90)90014-X
-
A. Holý, I. Votruba, A. Merta, J. Černý, J. Veselý, and J. Vlach Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro Antiviral Res 13 1990 295 311 (Pubitemid 20223544)
-
(1990)
Antiviral Research
, vol.13
, Issue.6
, pp. 295-311
-
-
Holy, A.1
Votruba, I.2
Merta, A.3
Cerny, J.4
Vesely, J.5
Vlach, J.6
Sediva, K.7
Rosenberg, I.8
Otmar, M.9
Hrebabecky, H.10
Travnicek, M.11
Vonka, V.12
Snoeck, R.13
De Clercq, E.14
-
8
-
-
0034672616
-
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes
-
R. Krejčová, K. Horská, I. Votruba, and A. Holý Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes Biochem Pharmacol 60 2000 1907 1913
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1907-1913
-
-
Krejčová, R.1
Horská, K.2
Votruba, I.3
Holý, A.4
-
9
-
-
23044524599
-
Phosphorylation of Purine (Phosphonomethoxy)alkyl Derivatives by Mitochondrial AMP Kinase (AK2 Type) from L1210 Cells
-
DOI 10.1135/cccc20001653
-
R. Krejčová, K. Horská, I. Votruba, and A. Holý Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 Type) from L1210 cells Collect Czech Chem Commun 65 2000 1653 1668 (Pubitemid 33230691)
-
(2000)
Collection of Czechoslovak Chemical Communications
, vol.65
, Issue.10
, pp. 1653-1668
-
-
Krejcova, R.1
Horska, K.2
Votruba, I.3
Holy, A.4
-
10
-
-
36849005953
-
Multidrug resistance in cancer: Its mechanism and its modulation
-
DOI 10.1358/dnp.2007.20.6.1141496
-
E.K. Pauwels, P. Erba, G. Mariani, and C.M. Gomes Multidrug resistance in cancer: its mechanism and its modulation Drug News Perspect 20 2007 371 377 (Pubitemid 350219069)
-
(2007)
Drug News and Perspectives
, vol.20
, Issue.6
, pp. 371-377
-
-
Pauwels, E.K.J.1
Erba, P.2
Mariani, G.3
Gomes, C.M.F.4
-
11
-
-
2442696471
-
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia
-
DOI 10.1124/jpet.103.063966
-
S. Dallas, L. Schlichter, and R. Bendayan Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia J Pharmacol Exp Ther 309 2004 1221 1229 (Pubitemid 38669713)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.309
, Issue.3
, pp. 1221-1229
-
-
Dallas, S.1
Schlichter, L.2
Bendayan, R.3
-
12
-
-
34250882212
-
Experimental therapy with 9-[2-(Phosphonomethoxy)ethyl]-2, 6-diaminopurine (PMEDAP): Origin of resistance
-
M. Zápotocký, J. Hanzalová, J. Starková, I. Votruba, A. Holý, and B. Otová Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance Folia Biol (Praha) 53 2007 79 84 (Pubitemid 46979029)
-
(2007)
Folia Biologica
, vol.53
, Issue.3
, pp. 79-84
-
-
Zapotocky, M.1
Hanzalova, J.2
Starkova, J.3
Votruba, I.4
Holy, A.5
Otova, B.6
-
13
-
-
0141535442
-
Pharmacological basis for cladribine resistance
-
DOI 10.1080/1042819031000099698
-
K. Lotfi, G. Juliusson, and F. Albertioni Pharmacological basis for cladribine resistance Leuk Lymphoma 44 2003 1705 1712 (Pubitemid 37221044)
-
(2003)
Leukemia and Lymphoma
, vol.44
, Issue.10
, pp. 1705-1712
-
-
Lotfi, K.1
Juliusson, G.2
Albertioni, F.3
-
14
-
-
20444368420
-
The 5′-nucleotidases as regulators of nucleotide and drug metabolism
-
DOI 10.1016/j.pharmthera.2005.01.003, PII S0163725805000227
-
S.A. Hunsucker, B.S. Mitchell, and J. Spychala The 5′-nucleotidases as regulators of nucleotide and drug metabolism Pharmacol Ther 107 2005 1 30 (Pubitemid 40800406)
-
(2005)
Pharmacology and Therapeutics
, vol.107
, Issue.1
, pp. 1-30
-
-
Hunsucker, S.A.1
Mitchell, B.S.2
Spychala, J.3
-
15
-
-
33750957951
-
Mitogen-Activated Protein Kinases and Chemoresistance in Pancreatic Cancer Cells
-
DOI 10.1016/j.jss.2006.06.031, PII S002248040600360X
-
Y. Zhao, S. Shen, J. Guo, H. Chen, D.Y. Greenblatt, and J. Kleeff Mitogen-activated protein kinases and chemoresistance in pancreatic cancer cells J Surg Res 136 2006 325 335 (Pubitemid 44737848)
-
(2006)
Journal of Surgical Research
, vol.136
, Issue.2
, pp. 325-335
-
-
Zhao, Y.1
Shen, S.2
Guo, J.3
Chen, H.4
Yu Greenblatt, D.5
Kleeff, J.6
Liao, Q.7
Chen, G.8
Friess, H.9
Sing Leung, P.10
-
16
-
-
79958140462
-
Synthesis of acyclic nucleoside phosphonates
-
Wiley-Liss Inc.
-
A. Holý Synthesis of acyclic nucleoside phosphonates Current Protocols in Nucleic Acid Chemistry 2005 Wiley-Liss Inc. (Chapter 14:Unit 14.2)
-
(2005)
Current Protocols in Nucleic Acid Chemistry
-
-
Holý, A.1
-
17
-
-
77957087824
-
3H-labeled acyclic nucleoside phosphonates and study of their stability
-
3H-labeled acyclic nucleoside phosphonates and study of their stability Collect Czech Chem Commun 75 2010 757 766
-
(2010)
Collect Czech Chem Commun
, vol.75
, pp. 757-766
-
-
Elbert, T.1
Břehová, P.2
Holý, A.3
-
18
-
-
77955058337
-
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP
-
M. Hájek, V. Cvilink, I. Votruba, A. Holý, and H. Mertlíková-Kaiserová Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP Eur J Pharmacol 643 2010 6 12
-
(2010)
Eur J Pharmacol
, vol.643
, pp. 6-12
-
-
Hájek, M.1
Cvilink, V.2
Votruba, I.3
Holý, A.4
Mertlí ková-Kaiserová, H.5
-
19
-
-
0027538652
-
Molecular targets in oncology: Implications of the multidrug resistance gene
-
B.L. Lum, M.P. Gosland, S. Kaubisch, and B.I. Sikic Molecular targets in oncology: implications of the multidrug resistance gene Pharmacotherapy 13 1993 88 109 (Pubitemid 23103055)
-
(1993)
Pharmacotherapy
, vol.13
, Issue.2
, pp. 88-109
-
-
Lum, B.L.1
Gosland, M.P.2
Kaubisch, S.3
Sikic, B.I.4
-
20
-
-
0037119431
-
Structural characterization of the closed conformation of mouse guanylate kinase
-
N. Sekulic, L. Shuvalova, O. Spangenberg, M. Konrad, and A. Lavie Structural characterization of the closed conformation of mouse guanylate kinase J Biol Chem 2002 30236 30243
-
(2002)
J Biol Chem
, pp. 30236-30243
-
-
Sekulic, N.1
Shuvalova, L.2
Spangenberg, O.3
Konrad, M.4
Lavie, A.5
-
21
-
-
65349098429
-
Mutation at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine
-
A. Ardiani, A. Goyke, and M.E. Black Mutation at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine Protein Eng Des Sel 22 2009 225 232
-
(2009)
Protein Eng des Sel
, vol.22
, pp. 225-232
-
-
Ardiani, A.1
Goyke, A.2
Black, M.E.3
-
22
-
-
0037129827
-
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
-
J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, and A. De Paepe Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 3 2002 1 12
-
(2002)
Genome Biol
, vol.3
, pp. 1-12
-
-
Vandesompele, J.1
De Preter, K.2
Pattyn, F.3
Poppe, B.4
Van Roy, N.5
De Paepe, A.6
|