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Volumn 82, Issue 2, 2011, Pages 131-138

Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG

Author keywords

Acyclic nucleoside phosphonates; Adenylate kinase; Guanylate kinase; PMEDAP; PMEG; Resistance

Indexed keywords

9 [2 (PHOSPHONOMETHOXYETHYL)DIAMINOPURINE; 9 [2 (PHOSPHONOMETHOXYETHYL)GUANINE]; ADENYLATE KINASE; GUANYLATE KINASE; NUCLEOTIDE DERIVATIVE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

EID: 79958174504     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.04.002     Document Type: Article
Times cited : (5)

References (22)
  • 1
    • 27844455955 scopus 로고    scopus 로고
    • Case history: Acyclic nucleoside phosphonates: A key class of antiviral drugs
    • DOI 10.1038/nrd1877, PII N1877
    • E. De Clercq, and A. Holý Acyclic nucleoside phosphonates: a key class of antiviral drugs Nat Rev Drug Discov 4 2005 928 940 (Pubitemid 41637695)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.11 , pp. 928-940
    • De Clercq, E.1    Holy, A.2
  • 4
    • 77955781919 scopus 로고    scopus 로고
    • Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells
    • H. Mertlíková-Kaiserová, I. Votruba, M. Matoušová, A. Holý, and M. Hájek Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells Anticancer Res 30 2010 2791 2798
    • (2010) Anticancer Res , vol.30 , pp. 2791-2798
    • Mertlíková-Kaiserová, H.1    Votruba, I.2    Matoušová, M.3    Holý, A.4    Hájek, M.5
  • 5
    • 52049093225 scopus 로고    scopus 로고
    • GS-9219 - A novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma
    • H. Reiser, J. Wang, L. Chong, W.J. Watkins, A.S. Ray, and R. Shibata GS-9219 - a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma Clin Cancer Res 14 2008 2824 2832
    • (2008) Clin Cancer Res , vol.14 , pp. 2824-2832
    • Reiser, H.1    Wang, J.2    Chong, L.3    Watkins, W.J.4    Ray, A.S.5    Shibata, R.6
  • 6
    • 0034742549 scopus 로고    scopus 로고
    • 6-substituted PMEDAP derivatives against T-cell lymphoma
    • M. Valeriánová, I. Votruba, A. Holý, V. Mandys, and B. Otová Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma Anticancer Res 21 2001 2057 2064 (Pubitemid 32728951)
    • (2001) Anticancer Research , vol.21 , Issue.3 B , pp. 2057-2064
    • Valerianova, M.1    Votruba, I.2    Holy, A.3    Mandys, V.4    Otova, B.5
  • 8
    • 0034672616 scopus 로고    scopus 로고
    • Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes
    • R. Krejčová, K. Horská, I. Votruba, and A. Holý Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes Biochem Pharmacol 60 2000 1907 1913
    • (2000) Biochem Pharmacol , vol.60 , pp. 1907-1913
    • Krejčová, R.1    Horská, K.2    Votruba, I.3    Holý, A.4
  • 9
    • 23044524599 scopus 로고    scopus 로고
    • Phosphorylation of Purine (Phosphonomethoxy)alkyl Derivatives by Mitochondrial AMP Kinase (AK2 Type) from L1210 Cells
    • DOI 10.1135/cccc20001653
    • R. Krejčová, K. Horská, I. Votruba, and A. Holý Phosphorylation of purine (phosphonomethoxy)alkyl derivatives by mitochondrial AMP kinase (AK2 Type) from L1210 cells Collect Czech Chem Commun 65 2000 1653 1668 (Pubitemid 33230691)
    • (2000) Collection of Czechoslovak Chemical Communications , vol.65 , Issue.10 , pp. 1653-1668
    • Krejcova, R.1    Horska, K.2    Votruba, I.3    Holy, A.4
  • 10
    • 36849005953 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Its mechanism and its modulation
    • DOI 10.1358/dnp.2007.20.6.1141496
    • E.K. Pauwels, P. Erba, G. Mariani, and C.M. Gomes Multidrug resistance in cancer: its mechanism and its modulation Drug News Perspect 20 2007 371 377 (Pubitemid 350219069)
    • (2007) Drug News and Perspectives , vol.20 , Issue.6 , pp. 371-377
    • Pauwels, E.K.J.1    Erba, P.2    Mariani, G.3    Gomes, C.M.F.4
  • 11
    • 2442696471 scopus 로고    scopus 로고
    • Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia
    • DOI 10.1124/jpet.103.063966
    • S. Dallas, L. Schlichter, and R. Bendayan Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia J Pharmacol Exp Ther 309 2004 1221 1229 (Pubitemid 38669713)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.309 , Issue.3 , pp. 1221-1229
    • Dallas, S.1    Schlichter, L.2    Bendayan, R.3
  • 12
    • 34250882212 scopus 로고    scopus 로고
    • Experimental therapy with 9-[2-(Phosphonomethoxy)ethyl]-2, 6-diaminopurine (PMEDAP): Origin of resistance
    • M. Zápotocký, J. Hanzalová, J. Starková, I. Votruba, A. Holý, and B. Otová Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance Folia Biol (Praha) 53 2007 79 84 (Pubitemid 46979029)
    • (2007) Folia Biologica , vol.53 , Issue.3 , pp. 79-84
    • Zapotocky, M.1    Hanzalova, J.2    Starkova, J.3    Votruba, I.4    Holy, A.5    Otova, B.6
  • 13
    • 0141535442 scopus 로고    scopus 로고
    • Pharmacological basis for cladribine resistance
    • DOI 10.1080/1042819031000099698
    • K. Lotfi, G. Juliusson, and F. Albertioni Pharmacological basis for cladribine resistance Leuk Lymphoma 44 2003 1705 1712 (Pubitemid 37221044)
    • (2003) Leukemia and Lymphoma , vol.44 , Issue.10 , pp. 1705-1712
    • Lotfi, K.1    Juliusson, G.2    Albertioni, F.3
  • 14
    • 20444368420 scopus 로고    scopus 로고
    • The 5′-nucleotidases as regulators of nucleotide and drug metabolism
    • DOI 10.1016/j.pharmthera.2005.01.003, PII S0163725805000227
    • S.A. Hunsucker, B.S. Mitchell, and J. Spychala The 5′-nucleotidases as regulators of nucleotide and drug metabolism Pharmacol Ther 107 2005 1 30 (Pubitemid 40800406)
    • (2005) Pharmacology and Therapeutics , vol.107 , Issue.1 , pp. 1-30
    • Hunsucker, S.A.1    Mitchell, B.S.2    Spychala, J.3
  • 16
    • 79958140462 scopus 로고    scopus 로고
    • Synthesis of acyclic nucleoside phosphonates
    • Wiley-Liss Inc.
    • A. Holý Synthesis of acyclic nucleoside phosphonates Current Protocols in Nucleic Acid Chemistry 2005 Wiley-Liss Inc. (Chapter 14:Unit 14.2)
    • (2005) Current Protocols in Nucleic Acid Chemistry
    • Holý, A.1
  • 17
  • 18
    • 77955058337 scopus 로고    scopus 로고
    • Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP
    • M. Hájek, V. Cvilink, I. Votruba, A. Holý, and H. Mertlíková-Kaiserová Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP Eur J Pharmacol 643 2010 6 12
    • (2010) Eur J Pharmacol , vol.643 , pp. 6-12
    • Hájek, M.1    Cvilink, V.2    Votruba, I.3    Holý, A.4    Mertlí ková-Kaiserová, H.5
  • 19
    • 0027538652 scopus 로고
    • Molecular targets in oncology: Implications of the multidrug resistance gene
    • B.L. Lum, M.P. Gosland, S. Kaubisch, and B.I. Sikic Molecular targets in oncology: implications of the multidrug resistance gene Pharmacotherapy 13 1993 88 109 (Pubitemid 23103055)
    • (1993) Pharmacotherapy , vol.13 , Issue.2 , pp. 88-109
    • Lum, B.L.1    Gosland, M.P.2    Kaubisch, S.3    Sikic, B.I.4
  • 20
    • 0037119431 scopus 로고    scopus 로고
    • Structural characterization of the closed conformation of mouse guanylate kinase
    • N. Sekulic, L. Shuvalova, O. Spangenberg, M. Konrad, and A. Lavie Structural characterization of the closed conformation of mouse guanylate kinase J Biol Chem 2002 30236 30243
    • (2002) J Biol Chem , pp. 30236-30243
    • Sekulic, N.1    Shuvalova, L.2    Spangenberg, O.3    Konrad, M.4    Lavie, A.5
  • 21
    • 65349098429 scopus 로고    scopus 로고
    • Mutation at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine
    • A. Ardiani, A. Goyke, and M.E. Black Mutation at serine 37 in mouse guanylate kinase confer resistance to 6-thioguanine Protein Eng Des Sel 22 2009 225 232
    • (2009) Protein Eng des Sel , vol.22 , pp. 225-232
    • Ardiani, A.1    Goyke, A.2    Black, M.E.3
  • 22
    • 0037129827 scopus 로고    scopus 로고
    • Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
    • J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, and A. De Paepe Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 3 2002 1 12
    • (2002) Genome Biol , vol.3 , pp. 1-12
    • Vandesompele, J.1    De Preter, K.2    Pattyn, F.3    Poppe, B.4    Van Roy, N.5    De Paepe, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.